Navigation Links
Vitamin A derivative associated with reduced growth in some lung cells

Treatment with a derivative of vitamin A called retinoic acid was associated with reduced lung cell growth in a group of former heavy smokers, according to a study published online October 30 in the Journal of the National Cancer Institute.

Former smokers remain at elevated risk for lung cancer. According to one hypothesis, lung cells that were damaged during years of smoking may continue to grow and evolve into cancer even after that person has quit smoking. Previous studies have suggested that retinoids, a class of drugs related to vitamin A, may be effective for preventing lung cancer in former smokers. Retinoids have also been shown to slow the growth of cancer cells in laboratory experiments.

Investigators at the University of Texas M.D. Anderson Cancer Center in Houston previously conducted a double-blind lung cancer prevention trial among 225 former heavy smokers. The subjects were randomly assigned to receive a 3-month treatment of 13-cis-retinoic acid and vitamin E, or 9-cis-retinoic acid, or a placebo. Walter Hittelman, Ph.D., and colleagues later examined biopsy samples of participants lung tissue taken before and after treatment, then measured the proliferation of the cells using a biomarker called Ki-67.

Both treatments reduced cell proliferation in one layer of the lung cells (the parabasal layer), but not the other (the basal layer), which surprised the researchers.

In patients given 13-cis-retinoic acid and vitamin E, there was a statistically significant reduction in parabasal layer cell growth compared with the placebo treatment, but not in those given 9-cis-retinoic acid. When the data were analyzed by the biopsy site, both treatments statistically significantly reduced cell growth.

It will therefore be important to distinguish the effects of molecularly targeted agents on the basal and parabasal [lung cell] layers in proposed lung chemoprevention trials with long follow-up, the authors write.

In an accompanying editorial, Eva Szabo, M.D., of the National Cancer Institute in Bethesda, Md., discusses the appropriateness of using the biomarker Ki-67 as an alternative endpoint in cancer prevention trials. While the biomarker showed that the retinoid agents were able to reduce cell growth, she says it is still too soon to test them in more advanced clinical trials. We do not have a full understanding of the effects of these agents on [lung cells] or their effects during the full spectrum of carcinogenesis, she writes.


Contact: Liz Savage
Journal of the National Cancer Institute

Related medicine news :

1. Vitamin B12 can help in detecting cancers
2. Vitamins-The answer to Heart Disease?
3. Vitamin E, the latest warrior against diabetes
4. Vitamin Shields Brittle Bones
5. Beer vitamin protects heart
6. B Vitamin protects and lowers toxicity of Arthritis Drug
7. B Vitamin Supplementatoin Saves Money and Lives
8. Eat Vitamin C and stay young
9. Taking Vitamin Supplements With Caution
10. Vitamin C reverses pre eclampsia
11. Bony Vitamin D a boon for lungs too
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... In an effort to ... Word of Life Christian Church of Flint, MI, hosted a family-oriented evening themed ... ton pile of candy dubbed “Candy Mountain”. , A Forever Recovery, a holistic ...
(Date:11/30/2015)... ... November 30, 2015 , ... During ... fundraising campaign to raise funds for its research, education, support, and advocacy efforts. ... organization’s annual funding. , The Mesothelioma Applied Research Foundation, which also goes by ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... Catalyst continuing education course in Dallas, TX, on January 29 and 30, 2016. ... to improve the functions of their practices, to learn how to better succeed ...
(Date:11/30/2015)... ... 2015 , ... HemoTreat™ has announced that the company has ... its website. , “Our goal is simple:” says Michael Blasco, HemoTreat’s Chief Communication ... chart and ingredient list allows our customers to quickly see why, and how, ...
(Date:11/30/2015)... Scotch Plains, NJ (PRWEB) , ... November 30, ... ... is their top choice for innovative, patient centered orthopedic care. Led by ... Regardless of your injury or chronic condition, the team at Advocare Orthopedic & ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 30, 2015  Hanger, Inc. (NYSE: HGR ) ... the terms of its previously announced consent solicitation (as ... $200,000,000 aggregate principal amount 7⅛% Senior Notes due 2018 ... consent fees payable pursuant to the Consent Solicitation, (ii) ... (iii) the expiration date of the Consent Solicitation.    ...
(Date:11/30/2015)... , Belgium , Nov. 30, 2015 ... sciences company focused on developing blood-based diagnostic tests for a ... the Company will present at the LD Micro Conference, which ... Los Angeles, CA. Attending from VolitionRx will be ... Scott Powell , Vice President of Investor Relations. ...
(Date:11/30/2015)... BOSTON , November 30, 2015 /PRNewswire/ ... potential new medicines directed at up to 10 G ... --> PFE ) to research and develop potential ... receptor (GPCR) targets across multiple therapeutic areas. --> ... discovery and development company and wholly-owned subsidiary of Sosei ...
Breaking Medicine Technology: