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Visceral fat causally linked to intestinal cancer
Date:3/5/2013

s. This was particularly remarkable in the case of our group where visceral fat was surgically removed, because these mice were still obese, they just had very little abdominal fat."

The researchers then subdivided the groups by gender. In female mice, the removal of visceral fat was significantly related to a reduction in intestinal tumors, but calorie restriction was not. In male mice, calorie restriction had a significant effect on intestinal tumors, but removal of visceral fat did not.

"This suggests that there are important gender differences in how adiposity and nutrients interact with the tumor environment," Huffman said. "In addition, the study emphasizes the need to promote strategies that reduce visceral fat in abdominally obese individuals."

Huffman noted that more studies are needed to definitively uncover the mechanisms behind the causality between visceral fat and intestinal cancer, to determine how abdominal obesity and nutrient availability act independently during the stages of tumor promotion and progression, and to determine how other strategies to promote weight loss, such as bariatric surgery, affect cancer risk.


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Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

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