Navigation Links
Virus mimics human protein to hijack cell division machinery
Date:5/8/2008

MADISON - Viruses are masters of deception, duping their host's cells into helping them grow and spread. A new study has found that human cytomegalovirus (HCMV) can mimic a common regulatory protein to hijack normal cell growth machinery, disrupting a cell's primary anti-cancer mechanism.

Writing in the May 9 issue of Science, researchers from the University of Wisconsin-Madison and Harvard Medical School report that a viral protein, called UL97, masquerades as a normal regulatory enzyme to modify a tumor-suppressing protein in human cells. Unlike the normal enzyme, which can be switched on and off by the cell as needed, the viral stand-in lacks an off switch and evades cellular control. The findings represent a previously unknown way that viruses can cause uncontrolled cell growth and division.

Cells normally have tight regulatory mechanisms in place to limit multiplication to appropriate situations, such as replacing worn-out cells or repairing damage. Uncontrolled cell proliferation can lead to cancer and other disorders.

One of the most important cellular control mechanisms works through a protein called the retinoblastoma tumor suppressor protein, which slows cell growth.

"The retinoblastoma pathway is like the brakes on a car. It prevents tumor cells from growing out of control," says Robert Kalejta, an assistant professor in the UW-Madison Institute for Molecular Virology and McArdle Laboratory for Cancer Research, who led the new study. "This pathway is mutated in essentially all human cancers."

Disrupting this pathway is also advantageous for viruses. Unable to reproduce on their own, viruses rely on co-opting their host's cellular machinery, like an occupying army taking over a local factory. They are especially good at overriding or bypassing built-in control mechanisms, Kalejta says.

"Viruses are well known to encode proteins that have similar activities to cellular proteins, but they're just
'/>"/>

Contact: Robert Kalejta
rfkalejta@wisc.edu
608-265-5546
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Grapefruit Compound Inhibits Hepatitis C Virus
2. New agent strikes at respiratory syncytial virus replication
3. OPEN LETTER: Medical Journal Calls Upon Barack Obama to Set the Record Straight on AIDS Virus
4. State Legislature Declares April 21 to 25, 2008 West Nile Virus and Mosquito and Vector Control Awareness Week
5. Study provides new understanding of forces behind seasonal flu virus evolution
6. Cedars-Sinai Medical Center opens patient trial of virus that attacks brain cancer cells
7. FDA OKs New Rotavirus Vaccine
8. FDA APPROVES ROTARIX(R) [Rotavirus Vaccine, live, oral], THE FIRST VACCINE LICENSED TO COMPLETE THE ROTAVIRUS IMMUNIZATION SERIES BY FOUR MONTHS OF AGE
9. Governor Rendell Proposes County Grants to Combat West Nile Virus, Protect Public Health
10. Biologists Discover How Dengue Virus Matures
11. Scientists see Norwalk virus Achilles heel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... 13, 2014 The North American water storage ... 2013 to $5,450 million by 2018, at a CAGR of ... is expanding at a rapid pace in North America. The ... laws on water & wastewater storage and collection, and the ... market is expanding at a healthy rate in Canada, and ...
(Date:7/13/2014)... Advanced boilers are preferred over conventional boilers because ... produce high-capacity power, emit fewer pollutants, and provide ... climate change concerns, many countries have implemented strict ... pollutants coming from fossilfuel-based power plants.North America had ... market., The global power rental market is witnessing ...
(Date:7/13/2014)... MarketsandMarkets recently conducted a study on ... 3D rendering; Layout and Animation; Image Reconstruction]: Global ... which analyzes and studies the major market drivers, ... Eastern Europe, Middle East and Africa, Asia-Pacific and ... landscape of the 3D imaging market, providing an ...
(Date:7/13/2014)... The Pearland, Texas location of The Little ... four months to 12 years of age that offers everything ... parties and Summer Camps, is now under new ownership. , ... after spending over six years at The Little Gym ... , Berry has over ten years of experience working ...
(Date:7/13/2014)... 2014 Recently, 2014QuinceaneraDresses.com, the distinguished ... its new range of gorgeous Quinceanera dresses ... demand for elegant Quinceanera outfits is huge. Therefore, ... All the company’s newly released dresses are made ... all elegant and vivid. , It is ...
Breaking Medicine News(10 mins):Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 3Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 2Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 3Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 2Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 3Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 4Health News:The Little Gym of Pearland, TX Now Under New Ownership and Management 2Health News:2014QuinceaneraDresses.com Releases Its New Quinceanera Dresses 2
... Simulator, from Electronic Sports, leads the next generation of exergaming fitness ... fun. , ... Salt Lake City, UT (PRWEB) December ... Dogfight, a full featured flight simulator interfaced with a high-end exercise ...
... PORTAGE, Ind., Dec. 16 MonoSol Rx, the ... company specializing in dissolving thin film pharmaceutical products, ... an agreement for thin film pharmaceutical products with ... a multinational pharmaceutical group focused on developing, manufacturing ...
... second Indiana Planned Parenthood clinic shows an emerging pattern of ... report the statutory rape of young girls. The new footage ... Project," a series of investigations documenting how secret abortions keep ... , In the video, shot undercover ...
... England and SAN FRANCISCO, Dec. 16 Enigma Diagnostics ... today that it has signed a term sheet for ... (RMS). , , The ... or licensed by RMS and its affiliates to practice ...
... BOTHELL, Wash., Dec. 16 SCOLR Pharma, Inc. (NYSE Alternext: DDD) ... Officer of the Company and as a member of its Board ... , Michael N. Taglich, Chairman of the Board of ... SCOLR,s entire organization, I would like to thank Dan for his ...
... Healthways executive brings 14-plus years of health industry expertise ... MINNEAPOLIS, Dec. 16 HealthFitness (NYSE Alternext ... as senior vice president of business and corporate development. ... services for on-site and dispersed employee populations. , ...
Cached Medicine News:Health News:Electronic Sports Launches Dogfight Fitness Flight Simulator: The Next Generation of Exergaming 2Health News:Electronic Sports Launches Dogfight Fitness Flight Simulator: The Next Generation of Exergaming 3Health News:MonoSol Rx Enters Agreement with Hikma Pharmaceuticals PLC for Thin Film Pharmaceutical Products in the Middle East 2Health News:MonoSol Rx Enters Agreement with Hikma Pharmaceuticals PLC for Thin Film Pharmaceutical Products in the Middle East 3Health News:Abuse Pattern Develops as Second Indiana Planned Parenthood Covers Up Statutory Rape of 13-Year-Old 2Health News:Enigma Diagnostics Announces a Signed Term Sheet for Patent Licenses with Roche Molecular Systems, Inc. 2Health News:SCOLR Pharma, Inc. Announces Resignation of CEO Daniel O. Wilds 2Health News:New SVP of Business and Corporate Development Joins HealthFitness 2
(Date:7/10/2014)... NEWPORT NEWS, Virginia , 11. ... führender Hersteller von Kameras für die ... Brust (MBI/BSGI), hat heute die CE-Zulassung ... Mit dem CE-Zeichen kann Dilon das ... seinen Vertriebsbereich auf den Großteil der ...
(Date:7/10/2014)... Yesterday, former Congressman Patrick Kennedy ... facility. Rep. Kennedy and Dick Moberg ... research in neurological disease and treatment. ... Garen Staglin , created One Mind, a ... that will radically accelerate the development and implementation ...
(Date:7/10/2014)... , July 10, 2014   LabStyle ... Management Solution, today announced the appointment of Professor ... member of its Board of Directors. ... and business experience to LabStyle as an entrepreneur, ... legal and corporate governance expert. He currently serves ...
Breaking Medicine Technology:Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4
... Feb. 22, 2011 Reportlinker.com announces that a ... catalogue: Global Pharmaceutical Contract Manufacturing ... This report analyzes the worldwide markets for ... following Dosage Forms: Injectables (Injections, Vials, and IV ...
... MedTrust Online (MedTrust) and Avantra Biosciences (Avantra) ... in the earliest stages of molecular diagnostic assay ... system. The two companies will ... care professionals with early access to the latest ...
Cached Medicine Technology:Reportlinker Adds Global Pharmaceutical Contract Manufacturing Industry 2Avantra Biosciences and MedTrust Online Partner to Develop Clinically Important Protein Biomarker Assays for Improving Cancer Care 2Avantra Biosciences and MedTrust Online Partner to Develop Clinically Important Protein Biomarker Assays for Improving Cancer Care 3
B-Hemoglobin test system provide quick, simple and reliable quantitative hemoglobin results. It has unbreakable, disposable cuvette which collect the exact amount of blood and mixes the sample with t...
... Variant hemoglobin testing system ... testing for diabetes monitoring, ... testing, hemoglobinopathy screening and ... single test. It has ...
AcT 5diff OV enables low-volume labs to advance to 5-part differential analysis at an affordable price. This analyzer delivers accurate test results and a user-friendly software interface in a compac...
... LH 755 simplifies and automates ... expert automation and advanced technologies ... reliable, accurate results every time. ... slide quality with its slide-on-slide ...
Medicine Products: