Navigation Links
Virus mimics human protein to hijack cell division machinery
Date:5/8/2008

MADISON - Viruses are masters of deception, duping their host's cells into helping them grow and spread. A new study has found that human cytomegalovirus (HCMV) can mimic a common regulatory protein to hijack normal cell growth machinery, disrupting a cell's primary anti-cancer mechanism.

Writing in the May 9 issue of Science, researchers from the University of Wisconsin-Madison and Harvard Medical School report that a viral protein, called UL97, masquerades as a normal regulatory enzyme to modify a tumor-suppressing protein in human cells. Unlike the normal enzyme, which can be switched on and off by the cell as needed, the viral stand-in lacks an off switch and evades cellular control. The findings represent a previously unknown way that viruses can cause uncontrolled cell growth and division.

Cells normally have tight regulatory mechanisms in place to limit multiplication to appropriate situations, such as replacing worn-out cells or repairing damage. Uncontrolled cell proliferation can lead to cancer and other disorders.

One of the most important cellular control mechanisms works through a protein called the retinoblastoma tumor suppressor protein, which slows cell growth.

"The retinoblastoma pathway is like the brakes on a car. It prevents tumor cells from growing out of control," says Robert Kalejta, an assistant professor in the UW-Madison Institute for Molecular Virology and McArdle Laboratory for Cancer Research, who led the new study. "This pathway is mutated in essentially all human cancers."

Disrupting this pathway is also advantageous for viruses. Unable to reproduce on their own, viruses rely on co-opting their host's cellular machinery, like an occupying army taking over a local factory. They are especially good at overriding or bypassing built-in control mechanisms, Kalejta says.

"Viruses are well known to encode proteins that have similar activities to cellular proteins, but they're just
'/>"/>

Contact: Robert Kalejta
rfkalejta@wisc.edu
608-265-5546
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Grapefruit Compound Inhibits Hepatitis C Virus
2. New agent strikes at respiratory syncytial virus replication
3. OPEN LETTER: Medical Journal Calls Upon Barack Obama to Set the Record Straight on AIDS Virus
4. State Legislature Declares April 21 to 25, 2008 West Nile Virus and Mosquito and Vector Control Awareness Week
5. Study provides new understanding of forces behind seasonal flu virus evolution
6. Cedars-Sinai Medical Center opens patient trial of virus that attacks brain cancer cells
7. FDA OKs New Rotavirus Vaccine
8. FDA APPROVES ROTARIX(R) [Rotavirus Vaccine, live, oral], THE FIRST VACCINE LICENSED TO COMPLETE THE ROTAVIRUS IMMUNIZATION SERIES BY FOUR MONTHS OF AGE
9. Governor Rendell Proposes County Grants to Combat West Nile Virus, Protect Public Health
10. Biologists Discover How Dengue Virus Matures
11. Scientists see Norwalk virus Achilles heel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... NJ (PRWEB) September 19, 2014 Visiting ... provider of home health care, hospice and palliative care ... to ring the Opening Bell yesterday at the New ... New Jersey philanthropist and social entrepreneur to care for ... Health Group has always worked to meet the urgent ...
(Date:9/19/2014)... (HealthDay News) -- U.S. military troops deployed to sunny ... according to a new study. Many returning ... In some cases, military personnel developed blisters on their ... or size of their moles since being deployed overseas. ... for skin cancer, the study authors noted. "The ...
(Date:9/19/2014)... 2014 (HealthDay News) -- Although there is mounting ... most middle-aged and older adults in the United ... according to new research. Less than one-quarter ... set by the Department of Health and Human ... essential for promoting health and fitness and staying ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 The ... important partnership with the National Fire Protection Association ... The collaboration, formalized today in a Memorandum of ... Members, factories, workers and other stakeholders with information, ... help protect the health and safety of workers ...
(Date:9/19/2014)... intact cells to treat and cure disease is ... is hindered by the inability of doctors and scientists ... these cells in patients without resorting to invasive procedures, ... 17 in the online journal Magnetic Resonance in ... Diego School of Medicine, University of Pittsburgh and elsewhere ...
Breaking Medicine News(10 mins):Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 2Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 3Health News:Some U.S. Troops May Face Greater Skin Cancer Risk 2Health News:Adults Over 45 Not Meeting U.S. Muscle Strengthening Guidelines, Study Says 2Health News:Alliance for Bangladesh Worker Safety and NFPA Sign Memorandum of Understanding to Strengthen Safety in Bangladesh Garment Factories 2Health News:Alliance for Bangladesh Worker Safety and NFPA Sign Memorandum of Understanding to Strengthen Safety in Bangladesh Garment Factories 3Health News:A better way to track emerging cell therapies using MRIs 2
... Ann Converso, RN, to Serve as President, WASHINGTON, ... the death of President Cheryl L. Johnson,RN. Johnson was ... Oct. 19, with a ruptured brain aneurysm and died ... friends., "Cheryl was a guiding force in the ...
... BASEL, Switzerland, Oct. 29 Roche (SWX: ROG.VX; RO.S),a ... it has extended its offer to acquire all of ... VMSI ),to 5:00 p.m., New York City time ... scheduled to expire at 5:00 p.m., New York City ...
... experts will summarize important new research on the ... consequences of acute kidney injury, racial and ethnic ... kidney disease patients, being presented during the American ... Exposition in San Francisco at a policy-centered news ...
... Fund Launch National Campaign to Inspire and ... Educate that Prevention is Possible, BERKELEY, Calif., Oct. ... in their lifetime. Although 50 percent,of women think breast cancer is ... of the disease. LUNA, the makers of whole nutrition bars ...
... ... Provider Earns $1.6 Million in Rebates This Year, Highlights ... Redwood City Project, REDWOOD ... nation,s largest not-for-profit,health plan, will today celebrate significant energy efficiency upgrades,and solar installations ...
... Cardiac Science,Corporation (Nasdaq: CSCX ), a ... announced today that it will present at the,18th ... York City. The,Company,s presentation is scheduled for Monday, ... Hinson, president and chief executive officer, will,review the ...
Cached Medicine News:Health News:UAN Mourns Passing of President Cheryl L. Johnson, RN 2Health News:Roche Extends Tender Offer for Ventana 2Health News:Roche Extends Tender Offer for Ventana 3Health News:Roche Extends Tender Offer for Ventana 4Health News:LUNA Pure Prevention Survey Confirms Breast Cancer Misconceptions 2Health News:LUNA Pure Prevention Survey Confirms Breast Cancer Misconceptions 3Health News:The Healing Power of Green 2Health News:The Healing Power of Green 3Health News:Cardiac Science to Present at the 18th Annual CIBC World Markets Healthcare Conference 2
(Date:9/19/2014)... and ORLANDO, Fla. , ... supporting Inspire therapy continues to grow, with the publication ... published on-line in Otolaryngology – Head and ... causes a worsening of both objective and subjective measures ... directly attribute Inspire therapy for the reduction in obstructive ...
(Date:9/19/2014)... 2014 Intarcia Therapeutics, Inc. today ... its lead candidate ITCA 650 (continuous subcutaneous delivery of ... HbA1c levels at the 50 th Annual Meeting ... (EASD). Data from the open-label, phase 3 FREEDOM-HBL (high ... in patients with poorly controlled type 2 diabetes. The ...
(Date:9/19/2014)... September 19, 2014 Reductions in ... many years in people with diabetes type 2 ... term benefits for the kidneys." Australian researchers ... type 2 diabetes leads to persistent reductions in kidney ... The global study has found that, five and ...
Breaking Medicine Technology:New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 4Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 2Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 3Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 4ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 2ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 3
... July 20, 2011 One of Frantz Medical Group,s ... it has been awarded an Ohio Third Frontier grant ... system for penetrating through vascular Chronic Total Occlusions (CTOs), ... Coronary Artery Bypass Graft (CABG).   VasoStar,s ...
... VEGAS, July 20, 2011 Cardinal Health today announced ... national trade show for independent pharmacies, is the largest ... attendees. This year,s event, taking place ... Palazzo resort hotel, features a 100,000-square-foot trade show floor, ...
Cached Medicine Technology:Frantz Medical Group Subsidiary, VasoStar, Awarded $1 Million Research Grant 2Frantz Medical Group Subsidiary, VasoStar, Awarded $1 Million Research Grant 3Nearly 7,000 Participate in Cardinal Health's Largest-Ever Annual Trade Show for Independent Pharmacies 2Nearly 7,000 Participate in Cardinal Health's Largest-Ever Annual Trade Show for Independent Pharmacies 3Nearly 7,000 Participate in Cardinal Health's Largest-Ever Annual Trade Show for Independent Pharmacies 4
Jaws with fine teeth. Serrated handle with polished finish. Jaws: Wide, 4.5 mm. With thumb catch lock....
Straight shafts with heavy Elschnig teeth. Flat serrated handle with slide style lock and polished finished....
Serrated handle with polished finish. Non-magnetic. Straight tips: Delicate 11 mm. Most popular size or model....
Delicate strong curved serrated tips. Serrated handle with dull finish....
Medicine Products: