Navigation Links
Virus caught in the act of infecting a cell

AUSTIN, Texas The detailed changes in the structure of a virus as it infects an E. coli bacterium have been observed for the first time, report researchers from The University of Texas at Austin and The University of Texas Health Science Center at Houston (UT Health) Medical School this week in Science Express.

To infect a cell, a virus must be able to first find a suitable cell and then eject its genetic material into its host. This robot-like process has been observed in a virus called T7 and visualized by Ian Molineux, professor of biology at The University of Texas at Austin, and his colleagues.

The researchers show that when searching for its prey, the virus briefly extends like feelers one or two of six ultra-thin fibers it normally keeps folded at the base of its head.

Once a suitable host has been located, the virus behaves a bit like a planetary rover, extending these fibers to walk randomly across the surface of the cell and find an optimal site for infection.

At the preferred infection site, the virus goes through a major change in structure in which it ejects some of its proteins through the bacterium's cell membrane, creating a path for the virus's genetic material to enter the host.

After the viral DNA has been ejected, the protein path collapses and the infected cell membrane reseals.

"Although many of these details are specific to T7," said Molineux, "the overall process completely changes our understanding of how a virus infects a cell."

For example, the researchers now know that most of the fibers are usually bound to the virus head rather than extended, as was previously thought. That those fibers are in a dynamic equilibrium between bound and extended states is also new.

Molineux said that the idea that phages "walk" over the cell surface was previously proposed, but their paper provides the first experimental evidence that this is the case.

Contact: Lee Clippard, Media Relations
University of Texas at Austin

Page: 1 2

Related medicine news :

1. Investigators trace of role reusable grocery bag in norovirus outbreak
2. 16th-century Korean mummy provides clue to hepatitis B virus genetic code
3. New study shows why swine flu virus develops drug resistance
4. Vygone Introduces A New Zapper For Effective Relief From Herpes Virus Related Skin Problems
5. Vygone Presents A New Product To Deal With Genital Warts And Other Herpes Virus Related Skin Problems
6. Moffitt researchers find cutaneous human papillomavirus infection a risk factor for skin cancer
7. Hepatitis C Virus Levels Higher in Certain Injection Drug Users
8. Antibodies for new rotavirus vaccines
9. SEARCH study shows 1-year drop in HIV virus levels in rural Ugandan parish after campaign
10. Human papillomavirus types do not replace others after large-scale vaccination
11. Only 1 in 4 Americans With HIV Has Virus Under Control: CDC
Post Your Comments:
(Date:9/20/2014)... (PRWEB) September 20, 2014 ... successful showing at the PAIN Week conference that ... Hotel and Casino in Las Vegas from September ... primarily attended PAIN Week in the hopes of ... a viable and legitimate tool to treat chronic ...
(Date:9/19/2014)... Nearly 780 Risperdal lawsuits are moving forward ... meeting took place to discuss the next steps in ... court’s mass tort program. Attorneys for the plaintiffs and ... the Complex Litigation Center in Philadelphia’s City Hall where ... Risperdal lawsuits filed against Johnson & Johnson and its ...
(Date:9/19/2014)... 19, 2014 “Copay coupons,” a drug ... brand drugs among patients with prescription drug coverage, may ... a new report from the Department of Health ... Federal anti-kickback laws prohibit suppliers from offering side-payments to ... federal government. , The report highlights that two recent ...
(Date:9/19/2014)... KS (PRWEB) September 19, 2014 Unbound ... responding to families in regions of the Philippines being affected ... , More than 1,060 families evacuated to the nearest public ... Fung-Wong brought heavy rain and gusty winds to portions of ... causing heavy flooding. Some homes filled with more than 10 ...
(Date:9/19/2014)... -- As kids transition from elementary to middle school, ... a recent study. But the researchers studying ... verbal and physical bullying declines as students get older. ... strategies must address all types of bullying as well ... researchers said. The study was published recently in ...
Breaking Medicine News(10 mins):Health Experiences Unprecedented Support and Growth at Pain Week 2014 2Health News:Risperdal Lawsuits Move Forward As Attorneys Meet To Discuss Litigation, Reports Wright & Schulte LLC 2Health News:Risperdal Lawsuits Move Forward As Attorneys Meet To Discuss Litigation, Reports Wright & Schulte LLC 3Health News:Risperdal Lawsuits Move Forward As Attorneys Meet To Discuss Litigation, Reports Wright & Schulte LLC 4Health News:PCMA: New OIG Report Cites Drug Manufacturer“Copay Coupon” Use in Medicare Part D 2Health News:Double Threat in Philippines Displaces Thousands of Unbound Families 2Health News: Cyberbullying Seems to Ramp Up in Middle School 2
... ... Point Solutions has been awarded the prestigious Gold certification from Cisco ... specialization. The Certification recognizes High Point,s expert level of achievement ... Communication, and Data Center. Gold Certified Partners are considered extensions of ...
... Biotherapeutics Inc. ("GENova") clarified today information disseminated in previous ... portfolio. , GENova owns the rights to a range ... all of them. The patents have not yet been ... been brought to GENova,s attention that previous releases were ...
... ... chiropractor, has taken over Optimal Body Chiropractic within Tuscan Sun Massage & Wellness in ... all ages by enhancing the relationship between the spine, nervous system, and the rest ... ...
... Public Health has been awarded $18.4 million by the ... Department of Defense to establish an Extremity Trauma Clinical ... coordinating center for the Consortium that includes a network ... several major military treatment centers and the U.S. Army ...
... young adults with acoustic neuromas , FRIDAY, Sept. 11 (HealthDay ... her mother,s voice or the sound of a dog barking. ... she had neurofibromatosis type 2 (NF2), a condition characterized by ... damaged the eighth cranial nerve in one ear. , The ...
... Sept. 11 United American Healthcare Corporation (Nasdaq: UAHC ... fourth fiscal quarter and full year ended June 30, 2009 on ... to file its Form 10-K for the period ended June 30, ... in compliance with applicable regulations. In addition, the Company announced ...
Cached Medicine News:Health News:High Point Solutions has Been Awarded the Prestigious Gold Certification from Cisco Systems 2Health News:GENova issues clarifying press release 2Health News:Chiropractic Helps Strengthen Immune System and Prevent Sickness 2Health News:JHSPH to lead extremity trauma clinical research consortium 2Health News:JHSPH to lead extremity trauma clinical research consortium 3Health News:Cancer Drug Shrinks Benign Tumors That Steal Hearing 2Health News:Cancer Drug Shrinks Benign Tumors That Steal Hearing 3Health News:United American Healthcare Corporation Announces Release Date for Fiscal 2009 Fourth Quarter and Full Year Results 2
(Date:9/19/2014)... 2014 Research and ... addition of the "Global Gynecological Devices ...      (Logo: , ... into wide categories based on their operations. ... of different gynecological conditions that affect the ...
(Date:9/19/2014)... CHICAGO , Sept. 19, 2014  4WEB Medical ... of 3D-printed foot and ankle osteotomy implants on ... and Ankle Society annual meeting in Chicago ... for all of a surgeon,s osteotomy needs with 74 size ... wedge systems had smaller offerings of only 15 to 18 ...
(Date:9/19/2014)... 19, 2014 UBM Medica US announces that  ... community to help oncologists and other clinicians gain a ... use of targeted therapies and immunotherapies, discusses some of ... Every September, Blood Cancer Awareness ... awareness about blood cancers—helping to increase survival rates and ...
Breaking Medicine Technology:Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 2Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 34WEB Medical Unveils 3D-Printed Osteotomy Truss System 2OncoTherapy Network Highlights National Blood Cancer Awareness Month 2OncoTherapy Network Highlights National Blood Cancer Awareness Month 3OncoTherapy Network Highlights National Blood Cancer Awareness Month 4
... BOSTON, Oct. 6, 2011 Solos Endoscopy, Inc. (OTCPK: ... support the National Breast Cancer Foundation (NBCF) by donating ... Instrument line for the month of October to the ... to hospitals across the Country through direct sales channels ...
... of dying from a heart attack is more than a fear ... reality. The mortality and morbidity rates for heart disease ... highest in Ohio, according to federal and state data. ... Regional Commission that will soon change. The federal grant will be ...
Cached Medicine Technology:Solos Endoscopy to Support National Breast Cancer Foundation With Sales of Its MammoView® Breast Endoscopy Components to US Hospitals 2Grant Will Help Save Lives in Appalachian Ohio 2