Navigation Links
Virus Shows Some Cancer-Killing Abilities
Date:10/30/2007

Results are promising but preliminary, experts caution,,,,

TUESDAY, Oct. 30 (HealthDay News) -- While most people associate viruses with human illness, a new study suggests that at least one virus might have cancer-fighting abilities that could be used to treat some metastatic cancers.

Reporting in the Nov. 7 issue of Journal of the National Cancer Institute, researchers explained that the virus, Seneca Valley Virus-001 (SVV-001), was effective in treating lines of cells from small-cell lung cancer and some pediatric cancers, as well as lung cancer and eye cancer in immune-deficient mice.

"In animal studies, we found complete eradication of small-cell lung cancer," said the study's lead author, Paul Hallenbeck, founder, president and chief scientific officer of Neotropix, in Malvern, Pa. "This is a promising new, yet old, approach to a very serious disease," added Hallenbeck, noting that people first noticed that viruses had some effect on cancer as long as 100 years ago.

However, at least one expert advised caution when interpreting these findings about the virus and metastatic cancer, which is cancer that has spread from one site in the body to another.

"These initial results look promising and warrant further investigation, but this is a very early study done in cell lines and an animal model," said Dr. Jay Brooks, chairman of hematology and oncology at Ochsner Health System in Baton Rouge, La. Brooks said there are still many questions that need to be answered about this virus, such as what are the long-term effects in humans, how expensive is it, will it continue to work in the long run, and would you have to be on it for the rest of your life?

Hallenbeck and his colleagues hope to answer the safety question shortly. They're in the midst of a phase I clinical trial that includes 18 people. Phase I trials are designed solely to look at whether or not a product is safe to administer in humans; they are not designed to assess effectiveness.

For the new study, Hallenbeck and other researchers reported on their results with cell lines and mice. Hallenbeck said he originally discovered the virus while working at a subsidiary of Novartis Pharmaceuticals, called Genetic Therapy. He said the virus is a previously undiscovered strain from the Picornaviridae family of viruses.

Previous viruses have shown cancer-fighting (oncolytic) ability. But, because the human immune system is primed to fend off viruses, oncolytic viruses may have trouble surviving until they reach their intended target -- the spreading cancer cells. To avoid this, researchers have been directly injecting viruses into tumors. But, according to Hallenbeck, if you're able to access a tumor well enough to inject the virus into it, that tumor can probably be well treated with surgery or radiation.

The SVV virus appears to be able to reach metastatic cancer cells without being inactivated by the immune system cells present in blood. With this virus, Hallenbeck is hoping to be able to track down metastatic cancer cells that can't easily be detected.

And, in cell lines, the virus appears to be effective at treating small-cell lung cancer and some pediatric cancers, without being inactivated by the immune system. The researchers also tested the virus in mice with deficient immune systems and found it was able to eradicate small-cell lung cancer in 10 out of 10 mice tested and knock out eye cancer in five out of eight mice tested.

"It is unclear whether these results from immune-deficient mouse models would be similar to those of patients with metastatic cancer. In particular, it is unknown whether the patients' immune system would reduce the effectiveness of SVV-001," the study authors wrote.

Hallenbeck said the phase I trial is expected to be completed some time next year. If all goes well in that trial, testing of the virus will move on to trials designed to measure effectiveness, he said.

More information

To learn about cancer advances made in recent years, visit the U.S. National Cancer Institute.



SOURCES: Paul Hallenbeck, Ph.D., M.S., president, founder, chief scientific officer, Neotropix, Malvern, Pa.; Jay Brooks, M.D., chairman, hematology/oncology, Ochsner Health System, Baton Rouge, La.; Nov. 7, 2007, Journal of the National Cancer Institute


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Virus Level could Predict Cervical Cancer Risk
2. Ebola Virus - Outbreak Claims More Lives In Uganda.
3. Experimental treatment for Ebola Virus Shows promising results in mice
4. Virus Combats Brain Tumour
5. Virus killer
6. Minor mutations in HIV virus
7. Virus makes Hodgkin’s disease more deadl
8. Infertility in relation with virus
9. Birds breed viruses
10. Hidden influenza virus protein found
11. Pain Killers Keep the Virus Away
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Virus Shows Some Cancer-Killing Abilities
(Date:1/19/2017)... ... January 19, 2017 , ... This month, the CEO and Clinical Director of ... drug rehab center in Delray Beach, Florida has been changed from Sober Living Outpatient ... as Philip Seymour Hoffman and Chris Farley are dying from heroin overdoses, but thousands ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... medical capacity this year. Drs. Alexander Paziotopoulos, Andrew Petersen and Trish Henrie-Barrus will ... version of the clinic’s leading recovery program. , “We know it’s easy ...
(Date:1/19/2017)... ... January 19, 2017 , ... In ... administered fillers that resulted in severe facial disfiguration. After four frightening years of ... doctors at UCLA Medical Center, who removed the substances in a partial facial ...
(Date:1/19/2017)... ... January 19, 2017 , ... Allegheny Health Network (AHN) ... who seek access to the Network’s programs and services in the greater Pittsburgh region. ... care appointments will be offered one for that same afternoon. , AHN ...
(Date:1/19/2017)... ... January 19, 2017 , ... St. Catherine’s Village announced that a ... is a skilled nursing facility on the grounds of the St. Catherine’s Village campus ... was voted the best nursing home in Mississippi for the second year in a ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... YORK , Jan. 19, 2017 This ... the current and future scenario of the global market. ... rising opioid consumption. Severe chronic constipation is a major ... to traditional laxatives. Hence, novel targeted therapy has been ... OIC sufferers, launch of targeted medicines, and growing awareness ...
(Date:1/19/2017)... NEW YORK , January 19, 2017 ... global market for cryotherapy is set to witness a CAGR of ... North America will continue to be the leading ... ... Suppliers are emphasizing on ensuring affordable and adequate supply ...
(Date:1/19/2017)... 19, 2017  Sensus Healthcare, Inc. (NASDAQ: ... in the treatment of non-melanoma skin cancers and ... radiation therapy, today announced that it will report ... results on Thursday, February 2, 2017 after the market ... conference call with the investment community on Thursday, February ...
Breaking Medicine Technology: