Navigation Links
Virus May Drive Some Prostate Cancers
Date:9/8/2009

Testing for XMRV might help spot more aggressive disease, experts say

TUESDAY, Sept. 8 (HealthDay News) -- A new study tightens the suspected link between a virus and prostate cancer, and raises the possibility that infection with the virus could be an indicator of aggressive tumors that require swift treatment.

"We're not making any causal association at this moment," stressed Dr. Ila R. Singh, an associate professor of pathology at the University of Utah, lead author of a report on the virus, known as xenotropic murine leukemia virus-related virus (XMRV).

"There probably are multiple causes of prostate cancer, but for the first time we have analyzed prostate cancer and normal prostate tissue and found cancers are much more likely to have [the virus]," Singh said.

The research is published in this week's issue of Proceedings of the National Academy of Sciences.

A link between XMRV and prostate cancer was first reported two years ago by researchers at the Cleveland Clinic and the University of California, San Francisco. They found the virus in cells around tumors.

The new study, involving more than 300 prostate cancer specimens, found that 27 percent of them carried the virus.

"It was also more likely to be present in more aggressive tumors," Singh said. "We found it in 20 percent of the least aggressive tumors and over 45 percent of the most aggressive tumors."

So, a test for presence of XMRV could be at least a partial solution to the major problem facing doctors who treat prostate cancer: distinguishing the minority of virulent, life-threatening cancers from the majority of tumors which grow so slowly that "watchful waiting" may be enough.

Prostate cancers now are diagnosed by a test for prostate-specific antigen (PSA), a protein produced by the gland. However, PSA tests cannot single out aggressive cancers, and there is a major debate on whether widespread use of these tests leads to overdiagnosis and overtreatment.

"I don't know yet if this is the better test, but it might be linked to more aggressive prostate cancers," Singh speculated.

Robert A. Silverman, a professor of cancer biology at the Cleveland Clinic, was one of the researchers who first reported the association of XMRV with prostate cancer. He called the new study "very exciting."

"Finding it in cancer cells makes it easier to reconcile with the idea of a cancer-causing virus than in our prior study," Silverman said. "The prior study found the virus in cells surrounding the cancer. We can't say with certainty that XMRV is a cause of cancer, but it still is a candidate for a cancer-causing virus."

Even if causation is not proved, "XMRV could be a marker for aggressive tumors," Silverman said.

His group has continued research on the virus, one of which indicates that human semen promotes the activity of XMRV, Silverman said.

The new study also overturns a previously reported association between XMRV infection and a genetic variation carried by a small percentage of men. "We don't find any such association," Singh said. So, the new research appears to expands the population at risk from the virus to all men -- whether they carry the genetic variant or not.

Singh and her colleagues are expanding their research on XMRV. "We don't know if women have the virus, and we are looking at cervical cells from Pap smears," she said. "We are looking at seminal fluid from men and also at tissues other than the prostate. We have two large series of autopsies of male and female organs. We are also looking for antibodies to the virus in serum as a way to detect infection."

More information

Find out more about prostate cancer at the U.S. National Cancer Institute.



SURCES: Ila R. Singh, M.D., Ph.D, associate professor, pathology, University of Utah, Salt Lake City; Robert A. Silverman, Ph.D, professor, cancer biology, Cleveland Clinic; Sept. 7, 2009, Proceedings of the National Academy of Sciences, online


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Virus Could Help Drive Obesity
2. Scientists detect presence of marburg virus in african fruit bats
3. Norwalk virus: Cruise ship illness challenging and costly to hospitals, too
4. Human Papilloma Virus vaccines may decrease chances of oral cancer
5. New viruses to treat bacterial diseases -- My enemies enemy is my friend
6. FDA Approves New Roche West Nile Virus Blood Screening Test
7. Laser blasts viruses in blood
8. Burgeoning Population of Hepatitis C Virus Patients in Need of Second- and Third-Line Treatment Options
9. Novel virus detection identifies new viruses in study of respiratory infections and asthma attacks
10. Customized virus kills brain tumor stem cells that drive lethal cancer
11. Stomach Virus a Culprit in Chronic Fatigue Syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Virus May Drive Some Prostate Cancers
(Date:10/13/2017)... ... , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many ... event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids ... of all ages; it is a non-competitive, non-timed event, which is all about having ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... DevOps and Agile Software Development, has been awarded a contract by the Center ... Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... for healthcare compliance program management, will showcase a range of technology and learning ... Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 at ...
(Date:10/12/2017)... ... 12, 2017 , ... The company has developed a suite ... regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been developed ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a ... health care, have expanded their existing home health joint venture through an agreement, ... been operating a joint venture home health company with Asante, delivering clinically integrated ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... WESTWOOD, Mass. , Oct. 4, 2017  According to the Centers ... by the end of October . PhysicianOne Urgent Care is helping communities ... Westchester, NY , by offering no-cost* flu shots through ... , as mandated by certain health insurance regulations. ... The best time to get a flu shot is by ...
(Date:10/2/2017)... Halo Labs announces the European launch of their new low volume, ... 2017 in Cambridge, U.K on October 4th. ... samples with unprecedented speed and sensitivity while using far less sample ... ... system ...
(Date:9/27/2017)... and NEW YORK , Sept. 27, 2017  DarioHealth ... and big data solutions, today announced that its MyDario product is expected ... local TV listings for when The Dr. Oz Show airs in your ... The nine-time Emmy ... ...
Breaking Medicine Technology: