Navigation Links
Virtual fly-through bronchoscopy yields real results
Date:10/3/2011

Reston, Va. -- For patients with non-small cell lung cancer (NSCLC) the accurate determination of the lymph node status before therapy is critical to develop an individualized treatment plan. Research from the October issue of the Journal of Nuclear Medicine highlights a new way for this information to be collected -- a virtual fly-through three-dimensional 18F-FDG PET/computed tomography (FDG-PET/CT) bronchoscopy that has high diagnostic accuracy for the detection of regional lymph node metastases.

According to Till A. Heusner, MD, senior author of the study "Diagnostic Accuracy of Virtual 18F-FDG PET/CT Bronchoscopy for the Detection of Lymph Node Metastases in Non-Small Cell Lung Cancer Patients," this is one of the first studies dealing with a virtual bronchoscopy program that integrates functional information and anatomical data.

To determine the effectiveness of the virtual bronchoscopy, researchers performed whole-body 18F-FDG PET/CT scans on 61 consecutive NSCLC patients. From the data collected, virtual 18F-FDG PET/CT bronchoscopies were reconstructed and diagnostic accuracy of detection of regional lymph node metastases was evaluated using the 18F-FDG PET/CT scans as a standard of reference. Researchers conducted their evaluation by measuring the mean duration time from the start of the virtual bronchoscopy until the images were displayed, maximum standardized uptake value (glucose metabolic activity) (SUVmax), SUVmean, short-axis diameter and the distance of the airways of the regional lymph nodes.

Results from the virtual fly-through bronchoscopy showed that the diagnostic accuracy for the detection of lymph node metastases was 81 percent. The mean duration from the start of the virtual 18F-FDG PET/CT bronchoscopy tool until image display was 22 seconds, and the mean smallest diameter of accessible bronchi was 3 mm. The differences in the SUVmax, SUVmean, short-axis diameter and distance to the airways among both true and false positive and true and false negative lymph nodes also were statistically significant. As such, the authors concluded that virtual 18F-FDG PET/CT bronchoscopy enables non-invasive fly-through -- even in relatively small airways in the periphery of the lung -- with high diagnostic accuracy.

According to Heusner, as a complement to PET/CT imaging the software may be used in the future to virtually visualize the bronchial system before interventional procedures, to plan optical bronchoscopies and define regions where a bronchoscopy-guided biopsy may be most promising for sampling of malignant tissue.

He added, "With the virtual fly-through three-dimensional 18F-FDG PET/CT bronchoscopy, nuclear medicine physicians may be able to present images that better meet the needs of the referring clinicians, as the tool simulates the bronchoscopic view a pulmonologist is accustomed to. This technique may also improve the process of acquiring tissue samples for characterization with emerging molecular diagnostics that can guide application of new targeted therapies in lung cancer."

Lung and bronchus cancers represent the cancer types with the most cancer-related deaths in the United States, both in female and in male patients. It was the most common newly diagnosed cancer type in the United States in 2010, with more than 220,000 patients diagnosed. NSCLC accounts for approximately 80 percent of all lung cancer disease.


'/>"/>
Contact: Susan Martonik
smartonik@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Related medicine news :

1. Rural Stroke Victims May Benefit From Virtual Care
2. Virtual Colonoscopy Still Has Its Skeptics
3. Returning vets alcohol abuse addressed in virtual reality study
4. International AIDS Society to launch Virtual Media Centre in July to support opioid substitution therapy in Eastern Europe and Central Asia
5. Virtual Reality May Help in Parkinsons Therapy
6. Virtual workout partners spur better results
7. Virtual lung models set to personalize asthma and COPD treatment
8. Nationwide utilization of virtual colonoscopy triples, study suggests
9. Virtual assistance is confirmed as an effective tool in monitoring HIV patients
10. Use of Virtual Colonoscopy on the Rise in U.S. Hospitals
11. Hospital use of virtual colonoscopy is on the rise, study suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... ... heart-wrenching story of child abuse and neglect, and the struggles faced while hoping ... is the creation of published author, Judy Von Bernewitz, who spent 13 years ...
(Date:8/22/2017)... , ... August 22, 2017 , ... ... Stewart is the Founder and Managing Member for t4 Leadership Development & Consulting. ... critical to his definition of “success”: physician leadership development, servant leadership, data driven ...
(Date:8/22/2017)... ... 22, 2017 , ... Although Labor Day is not as popular for fireworks ... weekend displays, and numerous households celebrate the unofficial end of summer with backyard fireworks ... pets. , Kris Zambo, owner of Dynamite Fireworks in Hammond, Indiana, ...
(Date:8/21/2017)... ... August 22, 2017 , ... The National ... a 2017-2018 inductee into its VIP Woman of the Year Circle. She is ... leading networking organization exclusively for professional women, boasting more than 850,000 members, a ...
(Date:8/21/2017)... ... August 21, 2017 , ... ... has become the Official Technology Partner of North Country Region Volleyball and will ... Systems) volleyball software, along with providing sport management software to their member clubs. ...
Breaking Medicine News(10 mins):
(Date:8/17/2017)... N.J. , Aug. 17, 2017 Bio-Ess Laboratories, LLC Chief ... increase antibody titer and present new data on Cell-Ess® Universal ... in Boston, MA August 21-25.  The Bioprocessing Summit ... today,s bioprocess challenges. ... and Optimizer ...
(Date:8/15/2017)... 2017 AccuGenomics, Inc., a diagnostic company based ... that the company has provided an AccuKit to the ... at Chapel Hill and to Qura Therapeutics for evaluation ... quantify HIV reservoir and viral expression in human CD4+ ... Cure Center is a joint initiative between the University ...
(Date:8/10/2017)... , Aug. 10, 2017  Physical Rehabilitation Network (PRN), acquired ... Lakewood, Colorado . The reputable clinic will ... , PT, DPT with his staff of four clinicians. Lipkin ... Pittsburgh and brings over 10 years of experience with a ... Belmar PT marks the 10th PRN clinic in and around ...
Breaking Medicine Technology: