Navigation Links
Virtual fly-through bronchoscopy yields real results
Date:10/3/2011

Reston, Va. -- For patients with non-small cell lung cancer (NSCLC) the accurate determination of the lymph node status before therapy is critical to develop an individualized treatment plan. Research from the October issue of the Journal of Nuclear Medicine highlights a new way for this information to be collected -- a virtual fly-through three-dimensional 18F-FDG PET/computed tomography (FDG-PET/CT) bronchoscopy that has high diagnostic accuracy for the detection of regional lymph node metastases.

According to Till A. Heusner, MD, senior author of the study "Diagnostic Accuracy of Virtual 18F-FDG PET/CT Bronchoscopy for the Detection of Lymph Node Metastases in Non-Small Cell Lung Cancer Patients," this is one of the first studies dealing with a virtual bronchoscopy program that integrates functional information and anatomical data.

To determine the effectiveness of the virtual bronchoscopy, researchers performed whole-body 18F-FDG PET/CT scans on 61 consecutive NSCLC patients. From the data collected, virtual 18F-FDG PET/CT bronchoscopies were reconstructed and diagnostic accuracy of detection of regional lymph node metastases was evaluated using the 18F-FDG PET/CT scans as a standard of reference. Researchers conducted their evaluation by measuring the mean duration time from the start of the virtual bronchoscopy until the images were displayed, maximum standardized uptake value (glucose metabolic activity) (SUVmax), SUVmean, short-axis diameter and the distance of the airways of the regional lymph nodes.

Results from the virtual fly-through bronchoscopy showed that the diagnostic accuracy for the detection of lymph node metastases was 81 percent. The mean duration from the start of the virtual 18F-FDG PET/CT bronchoscopy tool until image display was 22 seconds, and the mean smallest diameter of accessible bronchi was 3 mm. The differences in the SUVmax, SUVmean, short-axis diameter and distance to the airways among both true and false positive and true and false negative lymph nodes also were statistically significant. As such, the authors concluded that virtual 18F-FDG PET/CT bronchoscopy enables non-invasive fly-through -- even in relatively small airways in the periphery of the lung -- with high diagnostic accuracy.

According to Heusner, as a complement to PET/CT imaging the software may be used in the future to virtually visualize the bronchial system before interventional procedures, to plan optical bronchoscopies and define regions where a bronchoscopy-guided biopsy may be most promising for sampling of malignant tissue.

He added, "With the virtual fly-through three-dimensional 18F-FDG PET/CT bronchoscopy, nuclear medicine physicians may be able to present images that better meet the needs of the referring clinicians, as the tool simulates the bronchoscopic view a pulmonologist is accustomed to. This technique may also improve the process of acquiring tissue samples for characterization with emerging molecular diagnostics that can guide application of new targeted therapies in lung cancer."

Lung and bronchus cancers represent the cancer types with the most cancer-related deaths in the United States, both in female and in male patients. It was the most common newly diagnosed cancer type in the United States in 2010, with more than 220,000 patients diagnosed. NSCLC accounts for approximately 80 percent of all lung cancer disease.


'/>"/>
Contact: Susan Martonik
smartonik@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Related medicine news :

1. Rural Stroke Victims May Benefit From Virtual Care
2. Virtual Colonoscopy Still Has Its Skeptics
3. Returning vets alcohol abuse addressed in virtual reality study
4. International AIDS Society to launch Virtual Media Centre in July to support opioid substitution therapy in Eastern Europe and Central Asia
5. Virtual Reality May Help in Parkinsons Therapy
6. Virtual workout partners spur better results
7. Virtual lung models set to personalize asthma and COPD treatment
8. Nationwide utilization of virtual colonoscopy triples, study suggests
9. Virtual assistance is confirmed as an effective tool in monitoring HIV patients
10. Use of Virtual Colonoscopy on the Rise in U.S. Hospitals
11. Hospital use of virtual colonoscopy is on the rise, study suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... ... April 30, 2016 , ... A ... use of the HyProCure sinus tarsi implant. ( http://www.cbc.ca/news/canada/ottawa/banned-quebec-dentist-pierre-dupont-working-as-chiropodist-in-ottawa-1.3515494 ) The ... minimally invasive procedure performed, when indicated, to correct the partial displacement of ...
(Date:4/29/2016)... Los Angeles, CA (PRWEB) , ... April 29, 2016 , ... ... Sarah Mirmelli, a mother and divorcee, shares her enthusiasm for Botox and lip injections, ... of the world famous youth oriented Coachella Valley Music and Arts Festival. The article ...
(Date:4/29/2016)... Atlanta, Georgia (PRWEB) , ... April 29, 2016 , ... ... 60 rural hospitals across the Southeast, celebrated the signature of Gov. Nathan Deal on ... by Rep. Geoff Duncan (R - Cumming), offers a 70% tax credit to individuals ...
(Date:4/29/2016)... ... April 29, 2016 , ... Coast Dental Fort Stewart ... at its new location in the Exchange Furniture Mall at 112 Vilseck Road in ... 50-inch Samsung Smart TV. Plus attendees will have the opportunity to meet general dentists ...
(Date:4/29/2016)... NY (PRWEB) , ... April 29, 2016 , ... ... and engineer of patented products, announces the Gyrociser, an exercise invention which aids ... worth $2 billion," says Scott Cooper, CEO and Creative Director of World Patent ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... Dr. Vivek Ahuja , ... phen Schmidt Join the Growing ... solutions for life sciences, today announced key new leaders have joined ... to a growing business.  This will bolster the company,s safety business ... joined ArisGlobal in the position of Vice President - Safety. George ...
(Date:4/28/2016)... New market research titled ... report that provides an overview of the Osteoarthritis,s ... identifying new targets and MOAs to produce first-in-class ... in this H1 2016 Osteoarthritis Pipeline report include ... Abiogen Pharma S.p.A., Ablynx NV, Achelios Therapeutics, Inc., ...
(Date:4/27/2016)... -- Elekta today announced that its leading-edge ... focal point of seven scientific presentations at ESTRO 35, ... & Oncology, taking place April 29 - May 3. ... and a high-field MRI scanner with sophisticated software that ... in real time. The MR-linac is designed to improve ...
Breaking Medicine Technology: