Navigation Links
Virtual colonoscopy allows detection of unsuspected cancers beyond colon
Date:3/22/2010

OAK BROOK, Ill. A new, large-scale study of more than 10,000 adults found that more than one in every 200 asymptomatic people screened with CT colonography, or virtual colonoscopy, had clinically unsuspected malignant cancer and more than half of the cancers were located outside the colon. The findings were published in the April issue of the journal Radiology.

"We are finding that virtual colonoscopy screening actually identifies more unsuspected cancers outside of the colon than within it," said lead author Perry J. Pickhardt, M.D., professor of radiology and chief of GI Imaging, at the University of Wisconsin School of Medicine & Public Health. "As with asymptomatic colorectal cancers identified by virtual colonoscopy screening, these cancers are often detected at an early, curable stage."

Colorectal cancer remains the second leading cause of cancer death in the U.S., and the National Cancer Institute estimated that there would be 146,970 new cases diagnosed in 2009 and 49,920 deaths. The disease is largely preventable through screening for colon polyps, which are benign growths that may develop into cancer if not removed. The American Cancer Society recommends that people at average risk for colorectal cancer begin regular colorectal cancer screening at age 50, but current compliance with this recommendation is below 50 percent. Many people resist screening because of the discomfort and inconvenience caused by the conventional optical colonoscopy test.

Virtual colonoscopy is less invasive than optical colonoscopy and produces precise and detailed "fly-through" images of the entire colon's interior without having to insert a scope. With virtual colonoscopy screening, there is essentially no risk of bleeding or of perforating the colon. There is no need for intravenous sedation, and the procedure is less costly than conventional optical colonoscopy. It also is more convenient, typically taking 10 minutes or less.

Virtual colonoscopy also allows for limited assessment of structures outside the colon (extracolonic), including the abdomen, pelvis and portions of the lungs. Additional diagnostic tests for unsuspected extracolonic findings are performed in about 6 percent of cases, nearly half of which ultimately prove to be clinically relevant.

"Optical colonoscopy cannot provide for any assessment beyond the colon itself, whereas virtual colonoscopy can detect a wide array of unsuspected extracolonic diseases, most notably cancers and aortic aneurysms," Dr. Pickhardt said.

For the study, Dr. Pickhardt and colleagues set out to determine the detection rate and clinical outcome of unsuspected malignancies detected with virtual colonoscopy in an asymptomatic screening population. The researchers retrospectively reviewed the medical records of 10,286 adults (5,388 men and 4,898 women) with a mean age of 59.8 years who were evaluated at either the University of Wisconsin or National Naval Medical Center. All of the adults had undergone colorectal cancer screening with virtual colonoscopy at the two centers between April 2004 and March 2008. The mean time for follow-up was 30.2 months.

Unsuspected cancer was confirmed in 58 patients, including 33 women and 25 men. Invasive colorectal cancer was found in 22 patients, and extracolonic cancer was found in 36 patients. Cancers in 31 patients (53.4 percent) were stage 1 or localized cancers.

"To our knowledge, none of the patients who presented with stage 1, stage 2 or localized disease at diagnosis has progressed to a higher stage," Dr. Pickhardt said. "The fact that so many of the cancers in our study were localized or detected at an early stage appears to have positively affected survival."

Extracolonic malignancies, which outnumbered cases of invasive colorectal cancer, included renal cell carcinoma, lung cancer and non-Hodgkin lymphoma, among others.

"Although extracolonic evaluation at screening CT colonography does carry some disadvantages, such as patient anxiety, inconvenience, or the potential for benign biopsy, our results suggest that early detection of asymptomatic extracolonic cancer represents an additional benefit of screening CT colonography that is not available with optical colonoscopy," Dr. Pickhardt said.

"Virtual colonoscopy is an accurate, safe and convenient screening test that could potentially be a life-saving examination," he added.


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Virtual Global Launches Cloudipedia.com to Help Cloud Computing Newbies
2. Virtual Colonoscopy a Good Bet for Elderly
3. Ifbyphones Virtual Call Center Software Saves DiabetesAmerica Over $240,000 Per Year
4. Half-Million Doctors Beg Senate to Kill the Bill - Virtual News Conference by Coalition of More Than 40 Medical Groups Sunday, 2 pm EST; Sweetheart Deals Punish Patients in Other States
5. Left/Right Healthcare Virtual Vigil Tonight at 9 PM Until Senate Votes; Broad Coalition Says Punishes Some States, Windfall for Insurance Companies
6. Sudden Cardiac Arrest Foundation Launches First Virtual Affiliate
7. Long Island Plastic Surgical Practice - the Largest in the U.S. - Opens Virtual Doors on a New, State-of-the-Art Website
8. First Global, Virtual Summit on Cognitive Health and Performance Features 200 Sharp Brains
9. Virtual Global Highlights Top Ten Misconceptions about Cloud Computing
10. Virtual reality and other technologies offer hope
11. New Virtual Program for Parents of Children with ADD / ADHD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... FL (PRWEB) , ... February 05, 2016 , ... ... the largest domestic franchisees of Popeyes Louisiana Kitchen restaurants, launched the 14th annual ... awareness for kids and adults with muscular dystrophy, ALS and related diseases that ...
(Date:2/5/2016)... ... February 05, 2016 , ... The Lymphoma ... innovative lymphoma research and serving the lymphoma community through a comprehensive series of ... host, Swirl, A Wine Tasting Event at the La Gorce Country Club in ...
(Date:2/5/2016)... ... ... Give To Cure today announced that it is working with ... Cure’s campaign that is crowdfunding clinical trials to help find cures faster for Alzheimer’s ... smart device. In 2015 alone, Venmo processed $7.5 billion in transactions among users. , ...
(Date:2/5/2016)... ... 2016 , ... Stuart Bentkover, MD, FACS is thrilled to announce ... most effective tattoo removal today, Dr. Bentkover is the only doctor in Central Massachusetts ... PicoSure has been approved by the Food and Drug Administration (FDA) as a safe ...
(Date:2/5/2016)... ... ... California Mobile Kitchens , a company that designs ... kitchen model, featuring customizable stainless steel interiors and a new, 26-foot unit. , ... in the U.S. Many of their units can be seen at sporting events, ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... YORK , Feb. 4, 2016   Bernstein Liebhard ... been filed in the United States District Court for the ... a class (the "Class") consisting of all persons or entities ... the "Company") (NASDAQ: INSY ) from March 3, 2015 ... Insys and certain of its officers with violations of the ...
(Date:2/4/2016)... , Feb. 4, 2016 Summary Breast ... cancer and the most common cancer in women worldwide, ... disease exceedingly prevalent. The number of women diagnosed with ... but the number of deaths has declined due to ... treatment has been revolutionized in the past four decades, ...
(Date:2/4/2016)... -- Mettler-Toledo International Inc. (NYSE: MTD ) today ... the highlights: , Sales in local currency ... year.  Reported sales decreased 3% as currency reduced sales ... earnings per diluted share as reported (EPS) were $4.44, ... EPS was $4.65, an increase of 10% over the ...
Breaking Medicine Technology: