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Virginia Tech's Rylander wins national biomedical engineering award
Date:12/1/2011

ed the "holey scaffold". This patented device is the first system capable of minimally invasive and non-destructive light sensitive, molecular sensing, and control of biological and transport processes within living organisms.

Rylander explained the "holey scaffold can be visualized as a miniature microscope used in conjunction with a living system. The holey scaffold is built from tissue scaffolding and is embedded with a network of hollow microchannels. Typically made from biodegradable synthetics or biological materials such as collagen, the scaffold promotes tissue growth."

She uses the scaffold to measure dynamic nanoparticle mass transport, temperature, cell viability, HSP expression, and reactive oxygen species (ROS) production in real-time within an in vitro tumor in a bioreactor or an in vivo tumor within a mouse. She uses a variety of nanoparticles including carbon nanotubes, novel embodiments of carbon nanotubes and fullerenes, and carbon nanohorns in combination with laser irradiation.

Rylander's goal is to have her treatment model used by clinicians to determine appropriate nanoparticle properties and laser parameters to achieve selective and effective cancer treatment.

Rylander is the director of Virginia Tech's Tissue Engineering, Nanotechnology, and Cancer Research Laboratory http://www.sbes.vt.edu/nrylander/ and the biomedical program is part of Virginia Tech's Institute for Critical Technology and Applied Science http://www.ictas.vt.edu/ .

Rylander earned her doctorate in biomedical engineering from the University of Texas at Austin in 2005 where she remained as a post-doctoral fellow jointly appointed in its biomedical engineering department and the Institute for Computational Engineering and Sciences.

As a post-doctoral researcher, she worked on the characterization of injury and heat shock protein expression in prostate cancer cells and tumors in response to elevated temperatures assoc
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Contact: Lynn Nystrom
tansy@vt.edu
540-231-4371
Virginia Tech
Source:Eurekalert  

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