Navigation Links
Virginia Tech Carilion researchers find surprising relationships in brain signaling
Date:9/12/2013

If the violins were taken away from the musicians performing Beethoven's 9th symphony, the resulting composition would sound very different. If the violins were left on stage but the violinists were removed, the same mutant version of the symphony would be heard.

But what if it ended up sounding like "Hey Jude" instead?

This sort of surprise is what scientists from the Virginia Tech Carilion Research Institute had during what they assumed to be a routine experiment in neurodevelopment. Previous studies had shown that the glycoprotein Reelin is crucial to developing healthy neural networks. Logically, taking away the two receptors that Reelin is known to act on early in the brain's development should create the same malformations as taking away Reelin itself.

It didn't.

"We conducted the experiment thinking we'd see the same defects for both cases Reelin deficiency and its receptors' deletion but we didn't," said Michael Fox, an associate professor at the research institute and the lead author of the study. "If you take away the receptors instead of the targeting molecule, you get an entirely separate set of abnormalities. The results raise the question of the identity of other molecules with which Reelin and the two receptors are interacting."

The study, first published online in June in Neural Development, could prove useful for the development of therapies and diagnostics to combat brain disease.

In the early stages of neural development, neurons grow from the retina to a small portion of the brain called the thalamus. All sensory information coming into the brain gets routed through this region, before being transmitted to the cerebral cortex for further processing. Because these ret
'/>"/>

Contact: Paula Byron
paulabyron@vt.edu
540-526-2027
Virginia Tech
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Waterproofing Virginia and Water Damage Virginia "Best of the Best" Awarded to Drainage & Erosion Solutions, LLC for Excellence by Follow Media Consulting, Inc.
2. Bodnar Chiropractic Center of Alexandria, VA Receives Top Honors for 2013 from Northern Virginia Magazine
3. Transvaginal Mesh Lawsuit News: New Orders Issued in Vaginal Mesh Litigations Underway in West Virginia Federal Court, Bernstein Liebhard LLP Reports.
4. Skechers Lawsuit Filed by Wright & Schulte Alleges that a Virginia Woman Sustained a Serious, Painful Knee Injury Due to the Dangerous Design of Shape-Ups
5. C.R. Bard Settles Its Second Transvaginal Mesh Case in West Virginia Multidistrict Litigation, Notes Parker Waichman LLP
6. NuvaRing Lawsuit Filed by Alonso Krangle Alleges that a Virginia Woman Developed Pulmonary Embolism Due to NuvaRing Use
7. Women's Strike Force Announces First Fund Distribution to Virginia House of Delegates Candidates for November Race
8. AFrame Digital Selected as Preferred Patient Telemonitoring Solution for Virginia Hospitals
9. Zac Brown Band Tickets Virginia Beach: The Zac Brown Band Adds a Concert Date on October 12, 2013 at the Farm Bureau Live at Virginia Beach, VA
10. Redskins Super Bowl Trophies Arrive at the Science Museum of Virginia
11. Richmond, Virginia Health Coach Ellen Bernstein Launches Innovative New Healthy Eating Website
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Universities of Manchester and Auckland suggest that both major forms ... , The findings, published today in the FASEB Journal ... diabetes and type-2 diabetes are both caused by the formation ... , The results, based on 20 years, work in New ... slowed down and potentially reversed by medicines that stop amylin ...
(Date:8/20/2014)... extracted acellular allogeneic nerve, from which Schwann ... been removed, reduced postoperative immune rejection. Simultaneously, ... substrates and base materials, such as the ... provide a good scaffold in the process ... nerve, similar to autologous nerve transplantation, can ...
(Date:8/20/2014)... The Workgroup for Electronic Data ... the use of health IT to create efficiencies ... for its annual fall conference, WEDI-Con 2014: The ... will take place at the HYATT Regency in ... diverse cross-section of payers, providers, government regulators, industry ...
(Date:8/20/2014)... August 20, 2014 If old age is ... cure for it. With extensive research on HGH and stem ... claims to have perfected the art of rubbing off decades ... new younger look with their revolutionary anti-aging hormone therapy and ... 21st century fountain of youth, the MD of MetroMD, Dr ...
(Date:8/20/2014)... The National Association of Hispanic Nurses ... Education Partnership Award (SEPA) grant from the National ... with the Hispanic Communications Network (HCN) entitled Hispanic ... NIH R25 program has been established to address ... health professionals by recruiting and interviewing bilingual role ...
Breaking Medicine News(10 mins):Health News:Scientists show type-1 and type-2 diabetes are caused by same underlying mechanism 2Health News:WEDI Releases Full Conference Agenda for Its Annual Fall Conference – WEDI-Con 2014 2Health News:WEDI Releases Full Conference Agenda for Its Annual Fall Conference – WEDI-Con 2014 3Health News:MetroMD Offers Revolutionary Anti-aging Hormone Therapy in Hollywood Area 2Health News:National Association of Hispanic Nurses (NAHN) Receives Five-Year Federal Grant from the National Institutes of Health (NIH) 2Health News:National Association of Hispanic Nurses (NAHN) Receives Five-Year Federal Grant from the National Institutes of Health (NIH) 3
... 18 Codexis, Inc. today announced that Joseph Sarret, ... Corporate Development from his previous position as Vice President, ... Shaw, Ph.D., President and CEO. Dr. Sarret was ... joined Codexis in 2005 as Corporate Counsel and Director, ...
... Inc. (Nasdaq: MDVN ) today announced ... U.S. Food and Drug Administration (FDA) to begin ... novel androgen receptor antagonist, in patients with metastatic ... chemotherapy. The placebo-controlled, double-blind, multinational trial will ...
... smaller and more contained, study finds , , WEDNESDAY, March 18 ... reduce the risk of death by as much as half, ... information on 1,044 women who were seen at a medical ... had developed a second breast cancer -- 455 with cancer ...
... PHR Taps into Latino Market Underserved by ... Information Systems, Inc. (OTC Bulletin Board: FVRL), ... Inc. (collectively, "MMR") provides consumer-controlled Personal Health ... safe deposit box storage solutions ( www.myesafedepositbox.com ...
... 18 Kensey Nash Corporation (Nasdaq: KNSY ) ... stock repurchase. The new program allows the Company to ... and outstanding shares of Common Stock and has no scheduled ... its available cash. "Given our strong cash position and the ...
... they learned from elders who have been through economic ... simply being thankful can calm economic anxiety; other key ... optimism; what to avoid?: elders say don,t listen to ... released in conjunction with national conference Aging in America ...
Cached Medicine News:Health News:Codexis Names Sarret SVP, Corporate Development 2Health News:Medivation Receives FDA Permission to Initiate Phase 3 Trial of MDV3100 in Castration-Resistant Prostate Cancer 2Health News:Medivation Receives FDA Permission to Initiate Phase 3 Trial of MDV3100 in Castration-Resistant Prostate Cancer 3Health News:Medivation Receives FDA Permission to Initiate Phase 3 Trial of MDV3100 in Castration-Resistant Prostate Cancer 4Health News:When Breast Cancer Recurs, Finding Pre-Symptoms Is Key 2Health News:MMR Information Systems Offers First Bilingual Personal Health Record Through The Latino Coalition 2Health News:MMR Information Systems Offers First Bilingual Personal Health Record Through The Latino Coalition 3Health News:MMR Information Systems Offers First Bilingual Personal Health Record Through The Latino Coalition 4Health News:Kensey Nash Announces 600,000 Share Stock Repurchase Program 2Health News:Kensey Nash Announces 600,000 Share Stock Repurchase Program 3Health News:New Survey: Top Lesson from Seniors About Economic Worries? Gratitude Trumps Fear 2
(Date:8/19/2014)... , Aug. 19, 2014  Boehringer Ingelheim today ... (FDA) accepted for review the New Drug Application ... and olodaterol delivered via the Respimat ® ... maintenance treatment of airflow obstruction in patients with ... and/or emphysema. Tiotropium + olodaterol FDC will not ...
(Date:8/19/2014)... -- According to Kalorama Information, electronic medical records (EMR) ... in healthcare a reality, and this a factor that ... Recovery and Reinvestment Act, the U.S. government dedicated $20.6 ... will start applying soon for use of paper records.  ... of the EMR industry, EMR 2014: The Market ...
(Date:8/19/2014)... Calif. , Aug. 19, 2014  Cardiva Medical, ... two tranches of a $16.5 million Series 3 private ... with GE Capital. The Company will use the proceeds ... facility to expand commercial efforts for its VASCADE® Vascular ... . Investing in Series 3 private ...
Breaking Medicine Technology:Boehringer Ingelheim Announces U.S. Filing for the Fixed-Dose Combination Tiotropium Plus Olodaterol for Patients with COPD 2Boehringer Ingelheim Announces U.S. Filing for the Fixed-Dose Combination Tiotropium Plus Olodaterol for Patients with COPD 3Boehringer Ingelheim Announces U.S. Filing for the Fixed-Dose Combination Tiotropium Plus Olodaterol for Patients with COPD 4Boehringer Ingelheim Announces U.S. Filing for the Fixed-Dose Combination Tiotropium Plus Olodaterol for Patients with COPD 5Boehringer Ingelheim Announces U.S. Filing for the Fixed-Dose Combination Tiotropium Plus Olodaterol for Patients with COPD 6Boehringer Ingelheim Announces U.S. Filing for the Fixed-Dose Combination Tiotropium Plus Olodaterol for Patients with COPD 7Boehringer Ingelheim Announces U.S. Filing for the Fixed-Dose Combination Tiotropium Plus Olodaterol for Patients with COPD 8Kalorama: EMR Paves the Way for Big Data 2Kalorama: EMR Paves the Way for Big Data 3Cardiva Medical, Inc. Announces Completion of the first two tranches of Series 3 Private Equity Financing and the Closing of a Senior Secured Debt Facility with GE Capital 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: