Navigation Links
Viral microRNAs responsible for causing AIDS-related cancer, new USC study shows
Date:1/13/2014

LOS ANGELES - For the first time, scientists and engineers have identified a critical cancer-causing component in the virus that causes Kaposi's sarcoma, the most common cancer among HIV-infected people. The discovery lays the foundation for developing drugs that prevent Kaposi's sarcoma and other related cancers.

"The mechanism behind the Kaposi's sarcoma-associated herpesvirus (KSHV) that causes healthy cells to become malignant is not well understood despite two decades of intensive studies," said S. J. Gao, Ph.D., professor of molecular microbiology and immunology at the Keck School of Medicine of the University of Southern California (USC) and principal investigator of the study. "This is the first time that a viral factor has been shown to be required for KSHV-induced malignant transformation. We have identified a mechanism by which these tiny viral molecules cause the cells to become malignant."

Distinguished by dark lesions on the skin, Kaposi's sarcoma most commonly develops in people who are infected with KSHV and also have compromised immune systems. Although many people infected with KSHV never show any symptoms, Kaposi's sarcoma is a persistent problem in areas where HIV infection is high and access to HIV therapy is limited. More than 90 percent of the population in some areas of Africa shows signs of KSHV infection, according to the American Cancer Society.

Gao and colleagues from the University of Texas at San Antonio (UTSA) and University of Texas Health Science Center at San Antonio studied KSHV using a rat stem cell model they developed in 2012. Until then, researchers had been unable to study the virus because most healthy cells, once infected with KSHV, died before turning into cancer cells.

In this study, which appears in the Dec. 26 edition of the peer-reviewed journal PLOS Pathogens, the team identifies a cluster of viral microRNA molecules that are necessary to transform healthy cells into ca
'/>"/>

Contact: Alison Trinidad
alison.trinidad@usc.edu
323-442-3941
University of Southern California - Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Does the bodys immune response to viral vector delivery systems affect the safety or efficacy of gene therapy?
2. Population Council awarded USAID cooperative agreement to develop non-antiretroviral HIV microbicide
3. PDL-1 antibody could help immune system fight off influenza viral infection, study suggests
4. BU researchers explore possible link between cognitive depressive symptoms and antiretroviral therapy uptake
5. Advanced Back Pain Website Tool is a Viral Approach to Treatment
6. Risk of HIV treatment failure present even in those with low viral load
7. Study identifies protein essential for immune recognition, response to viral infection
8. Pregnant women with hepatitis C may pass heartier viral strain to newborns, study suggests
9. Findings: How viral infection disrupts neural development in offspring, increasing risk of autism
10. Casey Gollan’s: Viral Marketing 101: A Complete Guide for Businesses
11. UC Davis Researchers Find How Viral Infection Disrupts Neural Development in Offspring, Increasing Risk of Autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... January 22, 2015 Yesterday, Senator ... (D-Concord) and Kristin Olsen (R-Modesto) were honored by ... in advancing biotechnology, biomedical science, medical device and ... each received the “2014 Life Sciences Champion” award ...
(Date:1/22/2015)... Four years since the release of their debut recording ... marriage of Avasa & Matthew Love – the duo are pleased ... release through White Swan Records on February 24, 2015. , THE ... path available to all of us to walk out of the ...
(Date:1/22/2015)... As interest in the value of spiritual support as ... Rev. Eric J. Hall , president and CEO of the ... the keynote speaker on January 27 at an international summit ... The conference, “Hope and Resilience: Innovative and Interdisciplinary Spiritual Care,” ...
(Date:1/22/2015)... Lower-Auto-Insurance.com has released a new blog post explaining the importance of ... the costs of an auto insurance policy . , Clients ... prices for their vehicle insurance policies. The safety a vehicle offers ... Because of this, drivers should always carry a first aid ...
(Date:12/26/2014)... 2014 The US represents the largest market ... 2013, GlobalData’s forecast estimates that sales of branded therapies were ... to the high incidence of the disease, high drug treatment ... and China. Increased sales of CRC therapies over the forecast ...
Breaking Medicine News(10 mins):Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 3Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 4
... consistent and regular night,s sleep, a new study suggests it ... to your health, increase motor and neurological deterioration, speed aging ... your "biological clock" genes work the same way as those ... research just published in the journal Aging, scientists from Oregon ...
... ... Spring Dishes , ... Bentonville, AR (PRWEB) March 1, 2010 -- Sam’s Club expands its wine offerings this ... Tempranillo variety is the basis of Infinite, complemented by a small proportion of Cabernet ...
... ... ... ... ...
... ... ... ... ...
... , ... ... ... ...
... ... ... ... ...
Cached Medicine News:Health News:'Biological clock' could be a key to better health, longer life 2Health News:'Biological clock' could be a key to better health, longer life 3Health News:Put Some Fiesta Into Dinner - Sam's Club Adds New Spanish Red Wine From Torres Winery 2Health News:FDA Appoints Highly Qualified Scientific Experts to Tobacco Products Scientific Advisory Committee 2Health News:FDA Appoints Highly Qualified Scientific Experts to Tobacco Products Scientific Advisory Committee 3Health News:Wellspring Camps Kicks Off National Nutrition Month With $500 Discount On Summer Enrollment 2Health News:Wellspring Camps Kicks Off National Nutrition Month With $500 Discount On Summer Enrollment 3Health News:Wellspring Camps Kicks Off National Nutrition Month With $500 Discount On Summer Enrollment 4Health News:Wellspring Camps Kicks Off National Nutrition Month With $500 Discount On Summer Enrollment 5Health News:Wellspring Camps Kicks Off National Nutrition Month With $500 Discount On Summer Enrollment 6Health News:USHEALTH Career Agency Announces America's Choice 2Health News:USHEALTH Career Agency Announces America's Choice 3Health News:USHEALTH Career Agency Announces America's Choice 4Health News:USHEALTH Career Agency Announces America's Choice 5Health News:Surgical Information Systems Introduces 'SIS OR View' to Maximize Communication and Improve Patient Safety in the Operating Room 2Health News:Surgical Information Systems Introduces 'SIS OR View' to Maximize Communication and Improve Patient Safety in the Operating Room 3Health News:Surgical Information Systems Introduces 'SIS OR View' to Maximize Communication and Improve Patient Safety in the Operating Room 4Health News:Surgical Information Systems Introduces 'SIS OR View' to Maximize Communication and Improve Patient Safety in the Operating Room 5
(Date:1/23/2015)... /PRNewswire/-- Harwood Feffer LLP ( www.hfesq.com ) is investigating potential ... ("Advaxis" or the "Company") (NASDAQ: ADXS ), ... to shareholders. On January 21, 2015, an ... Advaxis had misrepresented the clinical data for its ADXS-HPV ...
(Date:1/23/2015)... , Jan. 23, 2015  iMD Companies, Inc. (ICBU) has repositioned ... market share and grab a foothold in the hydroponic, hemp ... capabilities and a presence in the sector, and recently partnering ... growth of hemp and medical marijuana, iMD is committing to ...
(Date:1/23/2015)... Jan. 23, 2015  CytoSorbents Corporation (NASDAQ CM: CTSO), ... extracorporeal cytokine adsorber to reduce deadly inflammation in ... of $385,642, net of transaction costs, in non-dilutive ... Business Tax Certificate Transfer Program sponsored by the ...
Breaking Medicine Technology:Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3
... DUBLIN , March ... launch of a new product that allows life science ... and efficiently while,allowing greater collaboration across the process. PRISYM ... that need to design,validate and approve labelling on a ...
... March 22 QRS Diagnostic, proven leader ... announces its latest release of Office Medic™ (version 5.3) ... operating systems. Office Medic™ is in use by over ... between providers, diagnostic test data and electronic medical records ...
Cached Medicine Technology:PRISYM ID's Medica Greatly Simplifies FDA and MHRA Compliance 2PRISYM ID's Medica Greatly Simplifies FDA and MHRA Compliance 3PRISYM ID's Medica Greatly Simplifies FDA and MHRA Compliance 4QRS Diagnostic Releases 64-bit and Windows(R) 7 Compatible Software 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: