Navigation Links
Viral Therapy Slows Pediatric Tumors in Mice
Date:2/15/2008

Treatment leaves healthy tissue unharmed while targeting solid masses, study finds

FRIDAY, Feb. 15 (HealthDay News) -- A laboratory-engineered virus can successfully slow the growth of two types of hard-to-treat pediatric tumors without harming healthy tissue, a new study shows.

The targeted viral therapy, dubbed rQT3, slowed neuroblastoma and peripheral nerve sheath tumors in mice, according to findings published in the Feb. 15 issue of Cancer Research. It also resulted in longer life spans in the mice compared with ones receiving just saline or other treatments for the tumors.

Neuroblastoma is the most common solid cancer tumor in childhood, most often striking those under age 5. Malignant peripheral nerve sheath tumors affect the connective tissue surrounding nerves.

Researchers at Cincinnati Children's Hospital Medical Center armed the oncolytic herpes simplex virus (oHSV)with a gene that steps up the body's work to block enzymes that aid the development and progression of certain cancers. Previous studies had shown oHSV can infect and kill human cancer cells without causing other harm or disease.

"Malignant solid tumors are still very difficult to treat effectively, especially without causing harm to normal tissues, so we need to find innovative therapeutic approaches," Dr. Timothy Cripe, a physician and researcher at Cincinnati Children's Hospital Medical Center, said in a prepared statement. "In our study, this tumor-targeting viral therapy enhanced anti-tumor activity by stimulating multiple biological processes, including directly killing the cancer cells and reducing the formation of blood vessels that fed the tumors. These data support continuing development and study of our tumor-targeted viral therapy to fight cancer."

The gene added to the virus carries instructions for a cancer-fighting protein, human tissue inhibitor of metalloproteinase 3 (TIMP3). TIMP3 blocks enzymes that aid the development and progression of cancer, called matrix of metalloproteinases (MMP).

MMPs help break down molecules that are important for the structural support and normal development of cells, organs and maintenance of tissues. However, when MMP activity becomes unbalanced, the enzyme plays a well-documented role in the formation of invasive and metastatic cancers, including pediatric neuroblastoma.

More information

The National Cancer Institute has more about childhood cancers.



-- Kevin McKeever



SOURCE: Cincinnati Children's Hospital Medical Center, news release, Feb. 15, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Vicriviroc Demonstrates Potent and Sustained Viral Suppression Through 48 Weeks of Therapy in Treatment-Experienced HIV-Infected Patients
2. IPM Reaches Landmark Agreement with Pfizer to Develop FDA-Approved Antiretroviral Drug as Vaginal Microbicide
3. Antiretroviral Drugs May Prevent Vaginal Transmission of HIV
4. MIGENIX Reports Preliminary Celgosivir Viral Kinetics Study
5. Antivirals reduce deaths from flu in hospitalized patients
6. American Medical Association Clears Path for Adenoviral Conjunctivitis - Pink Eye - Detector
7. Is it pancreatitis in acute abdominal pain in acute viral hepatitis?
8. Mayo Clinic Proceedings article explores possible link between obesity and viral infections
9. Antiviral Wont Improve Bells Palsy Outcome
10. Key Viral Change Could Help Bird Flu Spread
11. DNA damage response confers a barrier for viral tumorigenesis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Viral Therapy Slows Pediatric Tumors in Mice
(Date:5/31/2016)... (PRWEB) , ... May 31, 2016 , ... Dr. Charles ... and Dentistry of New Jersey in the class of 1986, where he graduated in ... dentistry at his current location in Livingston since 1989. He has been a member ...
(Date:5/31/2016)... ... 2016 , ... To meet a growing demand for professionals ... University of Scranton is adding a Certificate in Health Informatics to its online ... growing field of healthcare information. , Healthcare organizations are under growing pressure ...
(Date:5/31/2016)... ... May 31, 2016 , ... Super Powder, a supplement ... on the go individuals and dedicated athletes, continues to transform the nutritional supplement industry ... whey, pea and milk protein, branched-chain amino acids (BCAA), alkaline minerals, wheat grass, digestive ...
(Date:5/30/2016)... ... May 30, 2016 , ... ... of FCPX," said Christina Austin - CEO of Pixel Film Studios. , ... Final Cut Pro X. Choose from abstract transitions to more simple wipes with ...
(Date:5/30/2016)... ... May 30, 2016 , ... Shaolin Institute ... 8-day-8 and 8-night special intensive summer training camp starts on June 17th on ... offers families and children a fun and unique experience with an opportunity to ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... and GERMANTOWN, Maryland , May ... QGEN ; Frankfurt Prime Standard: QIA) today announced that ... with Therawis Diagnostics GmbH to develop and commercialize predictive assays ... market PITX2 as a marker to predict effectiveness of anthracycline ... "We are pleased to partner with Therawis, which ...
(Date:5/25/2016)... As illustrated by the Spring ... the numbers and momentum of cannabis in the US ... billions, more research and development push the sector forward. ... Legal Marijuana Markets Report  from from ArcView Market Research ... the increase in sector is attributed to adult use ...
(Date:5/25/2016)... , May 25, 2016 ... the precision of circulating tumour DNA (ctDNA) analysis ... the appointment of Professor Clive Morris ... leadership across the clinical development programme, scientific collaborations, ... help deliver significant improvements in clinical outcomes for ...
Breaking Medicine Technology: