Navigation Links
Viral Therapy Slows Pediatric Tumors in Mice
Date:2/15/2008

Treatment leaves healthy tissue unharmed while targeting solid masses, study finds

FRIDAY, Feb. 15 (HealthDay News) -- A laboratory-engineered virus can successfully slow the growth of two types of hard-to-treat pediatric tumors without harming healthy tissue, a new study shows.

The targeted viral therapy, dubbed rQT3, slowed neuroblastoma and peripheral nerve sheath tumors in mice, according to findings published in the Feb. 15 issue of Cancer Research. It also resulted in longer life spans in the mice compared with ones receiving just saline or other treatments for the tumors.

Neuroblastoma is the most common solid cancer tumor in childhood, most often striking those under age 5. Malignant peripheral nerve sheath tumors affect the connective tissue surrounding nerves.

Researchers at Cincinnati Children's Hospital Medical Center armed the oncolytic herpes simplex virus (oHSV)with a gene that steps up the body's work to block enzymes that aid the development and progression of certain cancers. Previous studies had shown oHSV can infect and kill human cancer cells without causing other harm or disease.

"Malignant solid tumors are still very difficult to treat effectively, especially without causing harm to normal tissues, so we need to find innovative therapeutic approaches," Dr. Timothy Cripe, a physician and researcher at Cincinnati Children's Hospital Medical Center, said in a prepared statement. "In our study, this tumor-targeting viral therapy enhanced anti-tumor activity by stimulating multiple biological processes, including directly killing the cancer cells and reducing the formation of blood vessels that fed the tumors. These data support continuing development and study of our tumor-targeted viral therapy to fight cancer."

The gene added to the virus carries instructions for a cancer-fighting protein, human tissue inhibitor of metalloproteinase 3 (TIMP3). TIMP3 blocks enzymes that aid the development and progression of cancer, called matrix of metalloproteinases (MMP).

MMPs help break down molecules that are important for the structural support and normal development of cells, organs and maintenance of tissues. However, when MMP activity becomes unbalanced, the enzyme plays a well-documented role in the formation of invasive and metastatic cancers, including pediatric neuroblastoma.

More information

The National Cancer Institute has more about childhood cancers.



-- Kevin McKeever



SOURCE: Cincinnati Children's Hospital Medical Center, news release, Feb. 15, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Vicriviroc Demonstrates Potent and Sustained Viral Suppression Through 48 Weeks of Therapy in Treatment-Experienced HIV-Infected Patients
2. IPM Reaches Landmark Agreement with Pfizer to Develop FDA-Approved Antiretroviral Drug as Vaginal Microbicide
3. Antiretroviral Drugs May Prevent Vaginal Transmission of HIV
4. MIGENIX Reports Preliminary Celgosivir Viral Kinetics Study
5. Antivirals reduce deaths from flu in hospitalized patients
6. American Medical Association Clears Path for Adenoviral Conjunctivitis - Pink Eye - Detector
7. Is it pancreatitis in acute abdominal pain in acute viral hepatitis?
8. Mayo Clinic Proceedings article explores possible link between obesity and viral infections
9. Antiviral Wont Improve Bells Palsy Outcome
10. Key Viral Change Could Help Bird Flu Spread
11. DNA damage response confers a barrier for viral tumorigenesis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Viral Therapy Slows Pediatric Tumors in Mice
(Date:5/6/2016)... ... 2016 , ... US Sports Camps has collaborated with State Rugby Organization (SRO), ... this summer. Employing world-class rugby figures, including former Team USA players and college coaches, ... key fundamentals, match play, fitness and more. , “US Sports Camps is honored to ...
(Date:5/6/2016)... FL (PRWEB) , ... May 06, 2016 , ... ... will feature AsedaSciences® in an upcoming episode, airing third quarter 2016, via Discovery ... the vision of becoming a leader in optimized drug discovery through innovative cellular ...
(Date:5/6/2016)... (PRWEB) , ... May 06, 2016 , ... Online HR/benefits ... and are changing the game for traditional brokers and health plans. “ The Rapid ... May 17 webinar from Atlantic Information Services, Inc. (AIS), will offer an accurate picture ...
(Date:5/6/2016)... ... 06, 2016 , ... Canadian author Mark Black is a speaker, author, and life ... around the world … with the help of his publisher Strategic Book Group and its ... in a hospital bed waiting for a miracle: He needed a heart and double-lung transplant. ...
(Date:5/6/2016)... ... 06, 2016 , ... Multiple award winning plumbing company in San ... years. Maintaining core values of exceptional customer service, quality work at reasonable rates, and ... name in San Diego plumbing, and other services including heating & air conditioning and ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... 3, 2016 BioNovus Innovations LLC and ... Advancing Medical Innovation (IAMI) today announced a new ... and medical devices. An agreement between ... to license, develop and commercialize medical innovations advanced ... "This partnership represents a significant advance in our ...
(Date:5/3/2016)...  As a teenager, an active and athletic ... his heart. He continued enjoying sports and recreation throughout ... heart was giving out and he was a few ... the Mesa, Arizona resident received ... heart transplant, the SynCardia TAH-t is the only approved ...
(Date:5/3/2016)... ORANGE COUNTY, Calif. , May 3, 2016  While you may be familiar with watching ... 4K resolution , also known as ultra-high-definition or 8MP in the Medical Industry.  Ampronix  is ... class manufacturer of innovative technology. Photo - http://photos.prnewswire.com/prnh/20160502/362730 ... ... ...
Breaking Medicine Technology: