Navigation Links
Viral Infection Might Trigger High Blood Pressure
Date:5/15/2009

Mouse study shows CMV raises risk of hypertension, hardening of arteries

FRIDAY, May 15 (HealthDay News) -- A hidden viral infection that most adults harbor could be a cause of high blood pressure, animal studies indicate.

Mice infected with cytomegalovirus (CMV) were more likely to develop not only high blood pressure but also the hardening of the arteries called atherosclerosis, according to a report in the May 15 issue of PLoS Pathogens by researchers at Beth Israel Deaconess Hospital in Boston.

"This could be of immense importance," said lead researcher Dr. Clyde Crumpacker, a professor of medicine at Harvard Medical School and an investigator in the Division of Infectious Diseases at Beth Israel Deaconess. "The implication for the human population is that antiviral therapy or a vaccine could be an intervention for high blood pressure."

CMV infection is widespread, Crumpacker noted. Studies indicate that between 60 percent and 99 percent of adults worldwide are infected, according to the study. But aside from pregnancy, where CMV infection is associated with serious birth defects, it causes no problems for most adults "until they get something that compromises the immune system," he noted.

"Vascular [blood vessel] injury has been suspected for quite a while," Crumpacker said. "What we have added, in collaboration with cardiologists, is evidence that in mice, CMV can cause an increase in blood pressure."

Blood vessel problems related to CMV infection were first noted in heart transplant recipients, Crumpacker said. Those who were CMV-positive were more likely to have blockage of the heart arteries.

The new study brought together specialists from several fields, including cardiology, virology and pathology to look at the phenomenon in mice. The study included four groups of mice, two fed a standard diet, and two fed a high-cholesterol diet. After four weeks, mice in one standard-diet group and one high-cholesterol group were infected with CMV.

"We were able to measure blood pressure directly in the arteries of the mice," Crumpacker said. The studies showed increased blood pressure in the infected mice after six weeks, but not in the uninfected group. It also showed that 30 percent of the infected mice in the high-cholesterol group developed atherosclerosis as well as high blood pressure.

There are several possible mechanisms for the pressure-raising effect of CMV, Crumpacker said. One is that it increases the activity of renin, an enzyme associated with high blood pressure. The study showed that CMV also increases activity of angiotensin 11, a protein involved in high blood pressure.

Most cases of high blood pressure in humans are of unknown origin, Crumpacker said. "Ninety-eight percent of the time, we don't know what the cause is," he said. If CMV infection is established as a cause -- something that requires much more research -- the way would be open for better methods of prevention and treatment, Crumpacker said.

"This is very exciting and important work," said Dr. Mark R. Schleiss, who holds the American Legion chair of pediatric infectious disease at the University of Minnesota and is a leading figure in the drive to develop a CMV vaccine.

"It is virtually certain that cytomegalovirus infection makes at least some contribution to cardiovascular disease in people," Schleiss said. "Obviously, cytomegalovirus is not the whole picture. There are other issues, including smoking, physical activity and diet. But this extends our body of knowledge about the role cytomegalovirus infection can play, and it is an important role, in cardiovascular disease."

The effort to develop a CMV vaccine has concentrated on childbirth, since infection during pregnancy is the leading cause of mental retardation and deafness in children, Schleiss said. "Now there is an urgency to develop a vaccine for men as well as women," he said.

More information

The dangers of cytomegalovirus infection are described by the U.S. Centers for Disease Control and Prevention.



SOURCES: Clyde Crumpacker, M.D., professor, medicine, Harvard Medical School, and investigator, Division of Infectious Diseases, Beth Israel Deaconess Hospital, Boston; Mark R. Schleiss, M.D., American Legion chair of pediatric infectious disease, University of Minnesota, Minneapolis; May 15, 2009, PLoS Pathogens


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Veterinarians at high risk for viral, bacterial infections from animals
2. Immune exhaustion driven by antigen in chronic viral infection
3. CDC Recommends Flocked Swabs and Copan-Manufactured Viral Transport Media for Collection of H1N1 (Swine Flu) Virus
4. The Viral Spiral - How A Meme About the Virus May Be More Contagious Than the Virus Itself
5. Using a small stockpile of a secondary antiviral drug in a flu pandemic
6. Nuvilex Advances Release of Citroxin(TM) Antiviral Surface Cleaner to Help Combat Swine Flu
7. Do patients at risk for B-cell malignancy need antiviral treatment?
8. National Public Health Week Begins Today With Launch of Viral Video Campaign
9. New insights into how brain responds to viral infection
10. Trial Vaccine May Protect Against Serious Viral Infection
11. Obio Pharmaceutical Announced New Antiviral Drug Discovery to Combat Influenza Virus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Viral Infection Might Trigger High Blood Pressure
(Date:5/26/2017)... ... May 26, 2017 , ... Water damage to the flooring of several ... had left education officials with a number of critical issues to address before students ... to be accomplished with little or no disruption to class schedules. Second, the project ...
(Date:5/24/2017)... ... 24, 2017 , ... In modern research, success depends greatly ... for research and understanding the basic principles that were designed to drive that ... in stereo microscopy for brightfield and fluorescence typically used in laboratories working on ...
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... Altec ... its participation in nVerge 2017 – a one-day technology conference in San Diego, CA. ... management solution, which allows users to fully utilize and enhance their Sage ERP solutions ...
(Date:5/24/2017)... ... May 24, 2017 , ... Drs. Nicholas Rallis and ... now spent 10 years as clinical instructors for the reputable Full Mouth Rehabilitation ... Through the program, private practitioners receive cutting-edge clinical training and learn how to ...
(Date:5/24/2017)... OH (PRWEB) , ... May 24, 2017 , ... Patients ... in Cortland, OH, can now meet with Dr. Joseph Bedich for a consultation, with ... while simultaneously improving their oral health and functionality. , Dr. Bedich offers ...
Breaking Medicine News(10 mins):
(Date:5/12/2017)...  The China and Canada joint tech ... water, energy and detergent, and features a powerful disinfection process. ... washing machine that washes and sanitizes women,s panties or babies, cloth ... ... does not require an external water inlet. ...
(Date:5/10/2017)... Mass., May 10, 2017 Hologic, Inc. (Nasdaq: ... results for the fiscal second quarter ended April 1, ... of $1.84 increased 666.7% compared to the prior year ... resulted in a significant gain, while non-GAAP diluted EPS ... 3.2%, or 3.8% in constant currency terms.  Excluding the ...
(Date:5/10/2017)... , May 10, 2017  The Corporate ... or employees of sleep therapy clinics to call ... sleep therapy clinic is involved in a substantial ... interested in hearing from an employee of a ... in a kickback scheme to provide medical practice groups ...
Breaking Medicine Technology: