Navigation Links
Vioxx Ban Tied to Rise in Serious GI Trouble
Date:11/8/2007

r.

"We got into this mess in the first place, because we had known for a long time that non-steroidals of all types have a well-documented increase in GI adverse events," he said. "So, we created two strategies to prevent them."

One strategy was to use a cox-2 inhibitor to help relieve pain. The other was to "buffer" an NSAIDs effect on the GI tract by giving patients medications such as proton pump inhibitors (PPIs), which protect against bleeding. PPIs include drugs such as Nexium and Prilosec.

The second strategy remains useful, he noted. "In patients who have known GI risk factors and are taking aspirin, most experts now suggest that you have to have additional gastroprotective therapy [such as a PPI] whether you are on a cox-2 inhibitor or not," Fendrick said.

Another expert agreed, but said doctors are often in a bind when a patient taking an NSAID comes to them with gastrointestinal problems.

Switching to the remaining cox-2, Celebrex, is an option, but many drug plans won't pay for it, said Joe Biskupiak, a research associate professor of pharmacology at the University of Utah in Salt Lake City.

"The easier solution is clearly taking a gastroprotective agent," he said.

Unfortunately, the blockbuster drug Prilosec has been sold over-the-counter since 2003, meaning that most drug plans won't pay for it, either.

"This creates a problem for physicians. They know what the right thing is to do -- just tell the patient to go to the store and buy [Prilosec]," Biskupiak said. "But many patients aren't going to do that."

The result is patients wind up with little protection against gastrointestinal troubles, he said.

So, was the FDA's decision to withdraw Vioxx and Bextra wrong?

"I don't have an answer to that," Singh said. "To my own mind, the whole noise around this issue has just led to a dramatic decrease in cox-2 inhibitor use but not a concomitan
'/>"/>

Copyright©2007 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. New study may explain Vioxx side-effects
2. Study Points to Cause of Vioxx Heart Risk
3. Longer ambulance journeys boost death risk for seriously ill patients
4. Heartburn Can Be a Sign of Serious Disease
5. Shaking may cause brain damage and serious long-term effects to infants
6. Serious Injury Rare With Police Tasers
7. Mayo Clinic clarifies diagnosis for serious blood vessel disease of brain and spinal cord
8. In the Aftermath: Smoke Odor and Fine Particulate Matter a Serious Concern
9. Quality-of-life yardstick needed for children with serious urologic conditions, Hopkins study shows
10. Hepatitis C treatment reduces the virus but serious liver problems may progress
11. Sleepless Kids Are Troubled Kids
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vioxx Ban Tied to Rise in Serious GI Trouble 
(Date:9/14/2014)... NY (PRWEB) September 14, 2014 Transvaginal ... filed in New Jersey, where two separate litigations are ... LLP reports. , According to Case Lists updated ... filed over devices marketed by C.R. Bard Inc., and ... involving cases against C.R. Bard, a total of 1,557 ...
(Date:9/14/2014)... School requires that children read at both near ... screened only for far vision when they enter school. , ... their eyes do not track effectively or focus (team) on ... avoid reading; at worst, they will think there is ... Children who cannot see cannot read. , On November ...
(Date:9/13/2014)... September 13, 2014 Ticket Down ... concert tickets. This beloved pop-rock group that originally formed in ... studio album. Fans of the group had been anticipating a ... If fans were excited yet about the release of their ... 5 has announced a massive worldwide tour beginning in the ...
(Date:9/13/2014)... York (PRWEB) September 13, 2014 Stryker ... of the 2012 Rejuvenate and ABG II Modular-Neck Hip ... underway in New Jersey’s Bergen County Superior Court, Bernstein ... issued by the Court on September 10th, 2,097 cases ... increase of 33 filings since the Court issued its ...
(Date:9/13/2014)... September 13, 2014 Hastings and Hastings, ... over 30 years of dedicated client friendly legal services. ... years of cumulative combined experience, Hastings and Hastings offers ... to clients. Even more impressive is the fact that ... boasts 11 offices located across the entire state of ...
Breaking Medicine News(10 mins):Health News:New Jersey Litigations Continue to Add Ethicon, C.R. Bard Transvaginal Mesh Lawsuits, Bernstein Liebhard LLP Reports 2Health News:New Jersey Litigations Continue to Add Ethicon, C.R. Bard Transvaginal Mesh Lawsuits, Bernstein Liebhard LLP Reports 3Health News:New Jersey Litigations Continue to Add Ethicon, C.R. Bard Transvaginal Mesh Lawsuits, Bernstein Liebhard LLP Reports 4Health News:Maroon 5 Tickets Now on Sale in Philadelphia, Washington DC, Nashville, San Jose, Chicago, Dallas, Los Angeles, Tacoma, Saint Paul, Vancouver, San Diego & New York 2Health News:Maroon 5 Tickets Now on Sale in Philadelphia, Washington DC, Nashville, San Jose, Chicago, Dallas, Los Angeles, Tacoma, Saint Paul, Vancouver, San Diego & New York 3Health News:Stryker Hip Lawsuit News: Rejuvenate and ABG II Hip Lawsuit Filings Near 2,100 in New Jersey Litigation, Bernstein Liebhard LLP Reports 2Health News:Stryker Hip Lawsuit News: Rejuvenate and ABG II Hip Lawsuit Filings Near 2,100 in New Jersey Litigation, Bernstein Liebhard LLP Reports 3Health News:Hastings & Hastings Reports Reaching 30 Years Of Dedicated Client Friendly Legal Services 2Health News:Hastings & Hastings Reports Reaching 30 Years Of Dedicated Client Friendly Legal Services 3
... This release is available in German . ... and learning about the warning signs of lymphedema: that,s ... lymphedema, according to the German Institute for Quality and ... about how to protect themselves from this common and ...
... AUGUSTA, Maine, Nov. 6 Building on the ... for small businesses in Maine,the Maine State Chamber ... and Blue Shield have announced further additions to ... January, Chamber,BlueOptions will include eight health plans from ...
... Invisicare Is Put In Place, LAS VEGAS, ... the developers of Invisicare, a patented polymer,delivery system ... of Geert Cauwenbergh, PhD to head its International,Advisory ... expand the demand,for Invisicare in international markets. Dr. ...
... Nov. 6 /Xinhua-PRNewswire-FirstCall/ -- Tianyin,Pharmaceutical, Co., Inc., (Amex: ... traditional Chinese medicine ("TCM") based in Chengdu, China,today ... to discuss its,2009 fiscal first quarter at 8:30 ... will be released that day before the market ...
... A steady march toward using,ever-more "patient-friendly" ... proceedings of the 37th Global Congress of ... international professional society for,specialists in minimally invasive ... preserving the highest possible quality of,life for ...
... People With,Diabetes and Their Caregivers, WESTPORT, Conn., Nov. ... laughter, and family, usually accompanied by trays of cookies,cakes, ... some,of the nearly 24 million people in America with ... dLife helped over 100,000 online,visitors survive the season with ...
Cached Medicine News:Health News:How women can improve their quality of life after breast cancer treatment 2Health News:Chamber BlueOptions Insurance Adds to its Options and Benefits for 2009 Suite of Insurance Plans Meeting Small Business Needs 2Health News:Chamber BlueOptions Insurance Adds to its Options and Benefits for 2009 Suite of Insurance Plans Meeting Small Business Needs 3Health News:Skinvisible Appoints Dr. Geert Cauwenbergh to Its International Advisory Board 2Health News:Skinvisible Appoints Dr. Geert Cauwenbergh to Its International Advisory Board 3Health News:Tianyin Pharmaceutical Co., Inc. to Host Fiscal Year 2009 First Quarter Earnings Conference Call on Tuesday, November 11, 2008 at 8:30 a.m. EST 2Health News:Hi-Tech Advances the Practice of Minimally Invasive Gynecology at AAGL Global Congress 2Health News:Hi-Tech Advances the Practice of Minimally Invasive Gynecology at AAGL Global Congress 3Health News:Hi-Tech Advances the Practice of Minimally Invasive Gynecology at AAGL Global Congress 4Health News:Back By Popular Demand - dLife Holiday Helpline 2
(Date:9/12/2014)... -- Royal Philips (NYSE: PHG AEX: PHIA) ... 56th Annual Meeting in San Francisco ... consistency and accuracy in cancer treatment. Producing quality results ... oncology solutions underscore Philips, dedication to leading healthcare into ... "Philips is leveraging our expertise in CT, ...
(Date:9/12/2014)... MARIETTA, Ga. , Sept. 12, 2014  WellStar ... Georgia and became the second in the ... sleep apnea.  As part of WellStar Health System, Paulding ... continually offering the latest treatments and solutions. ... sleep apnea in patients who are unable to use ...
(Date:9/12/2014)... According to the new research ... Infectious Diseases Testing Kits, Cardiac & Tumor Markers), by ... & Prescription Based - Global Forecast to 2018" published ... over the forecast period of 2013 to 2018. The ... 9.3% from 2013 to 2018, to reach $27.5 billion ...
Breaking Medicine Technology:Philips Demonstrates Commitment to Radiation Oncology Solutions at ASTRO 2014 2Philips Demonstrates Commitment to Radiation Oncology Solutions at ASTRO 2014 3WellStar Pioneers New Sleep Apnea Treatment 2Point-Of-Care Diagnostic Market Worth $27.5 Billion by 2018 2Point-Of-Care Diagnostic Market Worth $27.5 Billion by 2018 3Point-Of-Care Diagnostic Market Worth $27.5 Billion by 2018 4
... May 16, 2011 /PRNewswire-Asia/ -- Global Pharm Holdings ... "Company"), a China-based leading vertically integrated pharmaceutical company ... cultivation businesses through its subsidiaries in the Anhui, ... financial results for the first quarter ended March ...
... MAYWOOD, N.J., May 16, 2011 New Jersey Center ... sites in the nation to treat advanced prostate cancer ... therapeutic class known as autologous cellular immunotherapies.  PROVENGE was ... for the treatment of men with asymptomatic or minimally ...
Cached Medicine Technology:Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 2Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 3Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 4Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 5Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 6Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 7Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 8Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 9Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 10Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 11New Jersey Center for Prostate Cancer & Urology Among First in Nation to Treat Advanced Prostate Cancer Patients with PROVENGE 2
0.2ml Gradient Block MBSR. Robot compatible block ejection mechanism. Stackable. (96 well block - holds 1 plate 0.2ml x 96 well plate)...
... PxE Thermal Cycler (PxE) is a licensed 96 ... features for value for money thermal cycling. ... sixteen years experience in manufacturing and retains a ... synonymous with other products in the range. ...
Custom programming of 3 hot blocks and 1 cold block, 30% reduction in cycling time, Unmatched well-to-well uniformity, No gradient feature...
... With Exceptional Performance The sleek ... might be the first things ... is designed for performance. With ... premium, its small footprint is ...
Medicine Products: