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Vion Reports 2007 Third Quarter and Nine-Month Results
Date:11/7/2007

ncluded in the clinical development of all new drugs. Therefore, the trial continues to accrue patients at a few sites in the United States in a cardiac sub-study.

Alan Kessman, Chief Executive Officer, commented, "We will be presenting preliminary information from our pivotal Phase II trial of Cloretazine(R) (VNP40101M) as a single agent in elderly de novo poor-risk AML at the American Society of Hematology Meeting in December." He concluded, "Our objective remains to file a New Drug Application (NDA) for Cloretazine(R) (VNP40101M) with the FDA in 2008 based on this trial. We are already working on preparing the appropriate documentation for the NDA."

With regard to the pivotal Phase III trial in relapsed AML of Cloretazine(R) (VNP40101M) in combination with cytarabine which is on clinical hold, the Company announced that discussions with the data safety monitoring board (DSMB) related to the findings of a medical and safety review of the trial had been completed. The next step of the process is to discuss the conclusions with the regulatory authorities. There can be no assurance that these discussions will result in a continuation of the Phase III trial or what the timing of any such continuation might be.

Vion Pharmaceuticals, Inc. is committed to extending the lives and improving the quality of life of cancer patients worldwide by developing and commercializing innovative cancer therapeutics. Vion has two agents in clinical trials. Cloretazine(R) (VNP40101M), a unique alkylating agent, is being evaluated in a Phase II pivotal trial as a single agent in elderly patients with previously untreated de novo poor-risk acute myelogenous leukemia. Clinical trials of Cloretazine(R) (VNP40101M) as a single agent in small cell lung cancer, with temozolomide in brain tumors, and with stem cell transplant in advanced hematologic malignancies, are also being conducted. Triapine(R), a potent inhibitor of a key step in DNA synthesis, is being evaluated in clin
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SOURCE Vion Pharmaceuticals, Inc.
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