Navigation Links
Vion Pharmaceuticals Announces Presentation of Data from Phase III Trial of Cloretazine(R) (VNP40101M) and Cytarabine in Relapsed Acute Myelogenous Leukemia at the ASCO(R) Annual Meeting
Date:6/2/2008

NEW HAVEN, Conn., June 2 /PRNewswire-FirstCall/ -- VION PHARMACEUTICALS, INC. (Nasdaq: VION) today announced that data from the Phase III trial of its lead anticancer agent Cloretazine(R) (VNP40101M) in combination with cytarabine in patients with first relapse of acute myelogenous leukemia (AML) had been presented at the 44th Annual Meeting of the American Society of Clinical Oncology (ASCO(R)) in Chicago, Illinois.

The Phase III trial started in March 2005 and was conducted in 69 sites in North America and Europe. In May 2007, after an interim analysis of 210 patients by the trial's data safety monitoring board (DSMB), the Company suspended treatment and enrollment of patients, and the U.S. Food and Drug Administration (FDA) placed the trial on clinical hold, due to increased mortality in the cytarabine plus Cloretazine(R) (VNP40101M) treatment arm of the study, as compared to the cytarabine plus placebo control arm. In January 2008, the Company announced that the FDA had lifted the clinical hold and that a new trial with a lower dose of Cloretazine(R) (VNP40101M) in combination with cytarabine and increased supportive care measures could be pursued in the future.

The objective response rate of the cytarabine and Cloretazine(R) (VNP40101M) treatment arm of the trial was 37% versus 19% for the control arm. The median response duration was 11.2 months on the treatment arm versus 8.1 months on the control arm. Overall survival was 4.2 months on the treatment arm versus 6 months on the control arm.

The Company reported that on-study mortality (deaths from all causes in less than or equal to 30 days or from adverse events in less than or equal to 60 days from any treatment cycle) was 39% for the cytarabine and Cloretazin
'/>"/>

SOURCE Vion Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Arena Pharmaceuticals to Present at the NewsMakers in the Biotech Industry Conference
2. Schering-Plough/Merck Pharmaceuticals Announce FDA Filing Acceptance of New Drug Application for Loratadine/Montelukast Tablet
3. Provectus Pharmaceuticals, Inc. Begins Phase 2 Clinical Trial for Metastatic Melanoma
4. Idenix Pharmaceuticals to Present at Two Upcoming Investor Conferences
5. Vista Partners Updates Coverage on Tapestry Pharmaceuticals
6. Transcept Pharmaceuticals, Inc. to Present at UBS 2007 Global Life Sciences Conference
7. Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Tapestry Pharmaceuticals, Inc.
8. Amylin Pharmaceuticals to Webcast Corporate Overview During 43rd Annual Meeting of the European Association for the Study of Diabetes
9. Major Pharma Clinical Case Studies From Amgen, AstraZeneca, GSK, Intermune, Cephalon Inc, Sunesis Pharmaceuticals and Dartmouth Medical School During Fall Clinical Focused Programs
10. Provectus Pharmaceuticals, Inc. releases summary results of phase 1 metastatic melanoma study
11. Class Settlement Could Result in Considerable Savings for Certain Consumers of Prescription Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... CT (PRWEB) July 11, 2014 ... the nation’s only non-profit dedicated exclusively to cell ... that Joshua Corday has joined the organization as ... fundraising professional with deep experience securing gifts and ... served as Annual Giving Director for NewYork Presbyterian ...
(Date:7/11/2014)... Global enterprises today are shifting towards the ... activities. Managed services offer these global enterprises a strategic ... resulted into rising operational costs to companies. The aim ... be the global market driver for expanding the managed ... services market is estimated to grow from $142.75 billion ...
(Date:7/11/2014)... 11, 2014 Presently, disposable medical suppliers ... equipment and supplies segment. During the past two decades, ... growth (on an average 12.5% per year), primarily owing ... Currently, the US is the largest market for disposable ... of 40%. The second position is held by Europe ...
(Date:7/11/2014)... PROVIDENCE, R.I. -- Researchers from The Miriam ... under age 65 have significantly higher rates of ... with mobility impairments were less likely to attempt ... quit-smoking treatments may not be sufficient for this ... online in advance of print in the ...
(Date:7/11/2014)... of its kind has found that organic foods ... their conventional counterparts, including more antioxidants and fewer, ... at an unprecedented 343 peer-reviewed publications comparing the ... plant-based foods, including fruits, vegetables, and grains. The ... differences between organic and non-organic foods. , ...
Breaking Medicine News(10 mins):Health News:Alliance for Cancer Gene Therapy (ACGT) Welcomes Joshua Corday as Senior Development Officer 2Health News:Alliance for Cancer Gene Therapy (ACGT) Welcomes Joshua Corday as Senior Development Officer 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 4Health News:Global Disposable Medical Supplies Market to See Robust Growth Through Next Decade, According to New TriMark Report Available at MarketPublishers.com 2Health News:Global Disposable Medical Supplies Market to See Robust Growth Through Next Decade, According to New TriMark Report Available at MarketPublishers.com 3Health News:Miriam Hospital study examines smoking prevalence 2Health News:Major study documents nutritional and food safety benefits of organic farming 2Health News:Major study documents nutritional and food safety benefits of organic farming 3
... and the elderly have slower response times when they have ... research suggests that much of that slower response is a ... healthy older people can be trained to respond faster in ... cognitive skills in this area aren,t so different from younger ...
... celiac disease -- an autoimmune disorder associated with a ... than the general population to report symptoms of depression ... gluten-free diet, according to researchers at Penn State, Syracuse ... often suffer from abdominal pain, constipation, decreased appetite, diarrhea, ...
... Teens are more likely to be obese if they had ... toddlers, according to a new study. The findings echo ... ties with their parents were more likely to be obese ... the latest study, researchers examined U.S. National Institute of Child ...
... -- Quitting smoking is one of the most common ... with six of 10 smokers requiring multiple attempts before ... Association. However, preparing a quit-smoking plan can greatly ... the single most important step smokers can take to ...
... The quality of the emotional relationship between a mother ... that child to be obese during adolescence, a new ... characteristics between mothers and their children during their toddler ... terms of the child,s emotional security and the mother,s ...
... team of neuroscientists, led by researchers at Mayo Clinic ... brain disorder that may be much more common than once ... Nature Genetics , the researchers say they identified 14 ... of hereditary diffuse leukoencephalopathy with spheroids (HDLS). This ...
Cached Medicine News:Health News:Elderly can be as fast as young in some brain tasks, study shows 2Health News:Elderly can be as fast as young in some brain tasks, study shows 3Health News:Elderly can be as fast as young in some brain tasks, study shows 4Health News:Women with celiac disease suffer from depression, disordered eating 2Health News:Women with celiac disease suffer from depression, disordered eating 3Health News:Mother-Toddler Bond May Influence Teen Obesity 2Health News:How to Make Your Quit-Smoking Resolution Stick 2Health News:Study links quality of mother-toddler relationship to teen obesity 2Health News:Study links quality of mother-toddler relationship to teen obesity 3Health News:Study links quality of mother-toddler relationship to teen obesity 4Health News:'Rare' brain disorder may be more common than thought, say Mayo Clinic scientists 2Health News:'Rare' brain disorder may be more common than thought, say Mayo Clinic scientists 3
(Date:7/10/2014)... BURLINGTON, Mass. , July 10, 2014 /PRNewswire/ ... three-quarters of surveyed infectious disease (ID) specialists are ... Medicines Company,s Orbactiv (oritavancin) for use as OPAT, ... to prescribe these agents to their hospital inpatients. ... percent) of OPAT patients are initiated on OPAT ...
(Date:1/15/2014)... Sono-Tek Corporation (OTC BB: SOTK) today announced sales of  ... to sales of $2,202,000 for the prior year period, an ... also shown growth over the preceding quarter,s sales, continuing a ... year. Markets that experienced sales increases over the prior year ...
(Date:1/15/2014)... Mich. , Jan. 15, 2014 As health officials ... flu virus, select Meijer pharmacies in Michigan ... throat to eligible patients, enabling Meijer pharmacists to administer tests ... protocol set by a physician participating in the study. ...
Breaking Medicine Technology:Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3
... Feb. 21, 2012 ConvaTec, a world-leading developer and ... care, today announces that Ken Berger will assume the ... the ConvaTec Board of Directors. Berger joins ... last ten years, most recently as Senior Vice President ...
... Feb. 21, 2012  Idenix Pharmaceuticals, Inc. (NASDAQ: IDIX ... overview at the Citi Global Healthcare Conference on February 27, ... New York City.   The live and archived ... of Events" in the Idenix Investor Center at ...
Cached Medicine Technology:ConvaTec Announces the Appointment of Ken Berger to the Position of CEO Effective March 6, 2012 2
Classic, stylish, and preppy, this collection features men's, women's and unisex styles....
The latest VALENTINO eyewear collection is a refined expression of sophisticated luxury,balancing ultimate feminine, chic styles against understated, minimalist mens models....
Stylish, elegant and feminine, these attractive frames provide refined and beautiful styles for women ages 40 and older....
The Nine West Eyewear collection is positioned to present today's styles with a sharp, edgy contemporary attitude tied into a clean design element....
Medicine Products: