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Vigorous exercise linked to gene activity in prostate
Date:2/1/2012

correlated with the exercise patterns the men reported on questionnaires.

The study revealed 109 genes were "up-regulated," or more active, and 75 were "down-regulated" or less active, among the men who exercised vigorously for at least three hours a week compared to those who exercised less. Among the genes that exhibited greater expression were a number that already are thought to help thwart cancer progression, including the well-known "tumor suppressor" genes BRCA1 and BRCA2, as well as genes involved in cell cycle and DNA repair. The authors are continuing to analyze the data, including investigating pathways that were down-regulated by vigorous physical activity.

The team plans to follow this small, preliminary study with an investigation in a larger population of men. In another future study, they plan to examine the effects of physical activity among men who already have experienced cancer recurrence. Further research on these genes, said Chan, may help to determine how exercise contributes to improved cancer survivorship, and suggest novel strategies for prevention.


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Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

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