Navigation Links
Vigorous exercise linked to gene activity in prostate
Date:2/1/2012

Scientists at the University of California, San Francisco (UCSF) have identified nearly 200 genes in the healthy prostate tissue of men with low-grade prostate cancer that may help explain how physical activity improves survival from the disease.

The study compared the activity of some 20,000 genes in healthy prostate tissue biopsied from several dozen patients.

The finding builds on two studies last year by UCSF and Harvard School of Public Health that showed brisk walking or vigorous exercise such as jogging for three or more hours a week was linked to a lowered risk of prostate cancer progression and death after diagnosis. Those earlier studies, however, offered no explanation as to why.

In the current work, to be presented Friday, February 3, 2012 at an American Society of Clinical Oncology (ASCO) meeting in San Francisco, the UCSF team teased out a molecular profile of 184 genes whose expression in the prostate gland is linked to vigorous exercise.

Understanding how the activity of these genes is impacted by vigorous exercise and how this might translate to a lowered risk of prostate cancer progression may help reveal new ways to manage the disease, said the senior author of the study, June Chan, ScD, the Steven and Christine Burd-Safeway Distinguished Professor at UCSF.

"Vigorous physical activity may provide clinical benefits for men diagnosed with earlier stage prostate cancer," she said. "The finding suggests some interesting leads on mechanisms by which physical activity may protect against prostate cancer progression."

Prostate cancer is one of the most commonly diagnosed cancers in the United States. More than 217,000 U.S. men are diagnosed with the disease, and some 32,000 men die from prostate cancer, each year, according to the National Cancer Institute.

The analysis involved examining the levels of expression, or activity, of the same 20,000 genes in 70 men. This information was correlated with the exercise patterns the men reported on questionnaires.

The study revealed 109 genes were "up-regulated," or more active, and 75 were "down-regulated" or less active, among the men who exercised vigorously for at least three hours a week compared to those who exercised less. Among the genes that exhibited greater expression were a number that already are thought to help thwart cancer progression, including the well-known "tumor suppressor" genes BRCA1 and BRCA2, as well as genes involved in cell cycle and DNA repair. The authors are continuing to analyze the data, including investigating pathways that were down-regulated by vigorous physical activity.

The team plans to follow this small, preliminary study with an investigation in a larger population of men. In another future study, they plan to examine the effects of physical activity among men who already have experienced cancer recurrence. Further research on these genes, said Chan, may help to determine how exercise contributes to improved cancer survivorship, and suggest novel strategies for prevention.


'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Related medicine news :

1. Vigorous exercise reduces breast cancer risk in African-American women
2. Bursts of Vigorous Activity Appear to Be a Stress-Buffer
3. Science Shows How Exercise Might Help in Prostate Cancer
4. Exercise a Good Pick-Me-Up After Cancer Treatment: Study
5. Health benefits of exercise may depend on cellular degradation, UT Southwestern researchers report
6. UGA College of Education finds exercise reduces anxiety symptoms in women
7. Need to Exercise More? Think How It Will Help You Now
8. Mouse Study Give Clues to Why Exercise Is Healthy
9. Exercise May Help Those at Higher Risk for Alzheimers: Study
10. Safety Tips for Cold-Weather Exercise
11. Downloadable tool helps cancer survivors plan and monitor exercise
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vigorous exercise linked to gene activity in prostate
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... advisory organization, welcomes S.S. Nesbitt as the latest addition to its growing list ... seven other locations throughout the Southeast, from Orlando to Huntsville and in between. ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... award winner and inspirational speaker Jan Fox will serve as keynote speaker at ... will provide participants with tools to more effectively communicate with their own organizational ...
(Date:2/10/2016)... ... February 10, 2016 , ... The ... been awarded the prestigious Distinguished Emerald Club of the World award, as determined ... magazine, one of the most respected trade publications serving private clubs. , “We’d ...
(Date:2/10/2016)... ... February 10, 2016 , ... Workrite Ergonomics this week ... series of monitor mounts ever. , “Our goal was to develop a product ... install system that we have ever created.” said Darren Hulsey, Product Manager for Workrite ...
(Date:2/10/2016)... ... 2016 , ... A new leadership team for Mid-South Youth Camp, operated by ... the announcement Monday night, Feb. 8, prior to the evening session of the university’s ... creator of GO! Camp, has been named director. Gayle McDonald, currently the assistant director ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... Feb. 10, 2016  Silicon Biosystems Menarini Inc., ... that help uncover the biological complexities of disease ... a developer of innovative technologies for genomics research, ... aimed at enabling translational researchers to obtain high-quality ... hundred tumor and normal cells in an optimized ...
(Date:2/10/2016)... India , February 10, 2016 ... a new market research report "Pharmaceutical Packaging Equipment Market ... Wrapping, Labeling & Serialization), by Product Type (Tablet, Powder, ... 2020", published by MarketsandMarkets, studies the global market during the ... expected to grow at a CAGR of 6.9% during ...
(Date:2/10/2016)... Feb. 9, 2016 On Tuesday, ... (FDA) met with its Arthritis Advisory Committee ... of Johnson & Johnson,s Remicade and most ... in the U.S. The Biologics Prescribers Collaborative ... - Alliance for Patient Access, American Association ...
Breaking Medicine Technology: