Navigation Links
Vigorous Exercise Aids Those With Obesity-Related Gene
Date:9/8/2008

Effect of mutation blunted in people with above-average activity scores, study finds

MONDAY, Sept. 8 (HealthDay News) -- Physical activity may reduce the risk of obesity in people with a genetic mutation that predisposes them to high body-mass index (BMI), says a U.S. study.

Recent research has shown a link between BMI and variants of the fat mass and obesity associated with the (FTO) gene. The mutations connected with obesity occur in about 30 percent of European populations and are associated with a 1.75-kilogram (3.9-lb.) increase in body weight, according to background information in the study.

While lifestyle factors such as diet and exercise are important factors in weight control, it's not exactly clear how they interact with genetics.

In this study, researchers analyzed DNA samples from 704 healthy Amish adults, average age 43.6, and also conducted a series of physiological tests on the participants, including recording their physical activity over a seven-day period.

Among the participants, 54 percent of men and 63.7 percent of women were overweight, and 10.1 percent of men and 30.5 percent of women were obese. The genetic analysis showed that 26 single-nucleotide polymorphisms (SNPs -- changes in a single base letter of DNA) in the FTO gene were associated with BMI.

Further investigation found that the two strongest SNPs were associated with BMI only in people with low physical activity scores. The SNPs had no effect on people with above-average physical activity scores.

The study was published in the Sept. 8 issue of the Archives of Internal Medicine.

"Activity levels in the 'high-activity' stratum were approximately 900 calories [860 calories for women and 980 calories for men] higher than in the 'low-activity' stratum, which, depending on body size, corresponds to about three to four hours of moderately intensive physical activity, such as brisk walking, housecleaning or gardening," the researchers wrote.

"In conclusion, we have replicated the associations of common SNPs in the FTO gene with increased BMI and risk to obesity in the Old Order Amish. Furthermore, we provide quantitative data to show that the weight increase resulting from the presence of these SNPs is much smaller and not statistically significant in subjects who are very physically active. This finding offers some clues to the mechanism by which FTO influences changes in BMI and may have important implications in targeting personalized lifestyle recommendations to prevent obesity in genetically susceptible individuals."

More information

The U.S. National Heart, Lung, and Blood Institute has more about overweight and obesity.



-- Robert Preidt



SOURCE: JAMA/Archives journals, news release, Sept. 8, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Manor Care To Vigorously Contest TRO
2. More Sweat Equals Lower Risk of Exercise-Induced Asthma
3. Exercise May Help Prevent Age-Related Memory Loss
4. September 2008 Mayo Clinic Womens HealthSource Highlights Normal Weight Obesity, Regular Exercise and Cholesterol
5. Active Video Games Help Kids Exercise
6. Exercise Lowers Risk of Colon Cancer
7. Immigrant Children Less Likely to Exercise
8. Creatine Has Negligible Effect on COPD Exercise Rehab
9. No substitute for hard work: Creatine supplementation does not improve exercise outcomes in COPD
10. Exercise Testing for Cancer Fails to Follow Guidelines
11. Making patients move requires the right exercise advice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... LINCOLN, R.I. (PRWEB) , ... May 26, 2016 , ... ... season. That’s why Amica Insurance is sharing tips to make sure your ... an estimate from the National Safety Council, there may be 439 deaths and an ...
(Date:5/26/2016)... ... May 26, 2016 , ... The Lung Institute has partnered with ... class starting June 6 at their clinic in downtown Tampa. The class is complimentary ... Lung Institute has created a free downloadable 4 Week Smoking Cessation Guide ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... of Mehling Orthopedics and chief medical officer of Blue Horizon International (BHI), Brian ... Regeneration. The conference was held during May 5-6, 2016 in Chicago, IL, USA. ...
(Date:5/26/2016)... ... May 26, 2016 , ... Power Systems, a leading developer ... Instructor Certification Course in Stoughton, Massachusetts. The course was led by Power Systems’ ... 8 hour interactive course to qualify participants as certified PowerWave trainers. , ...
(Date:5/26/2016)... ... May 26, 2016 , ... On May 23rd during the National ... Science® and international water advocate, was honored by Ashram, Inc. as the world’s foremost ... who knelt on the banks of the Nile to fill their red clay pots ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... FDA 510(k) clearance covers ... for urological and surgical applications Mauna ... Cellvizio®, the multidisciplinary confocal laser endomicroscopy (CLE) platform, ... US with the 12 th 510(k) clearance ... This new FDA clearance covers Confocal Miniprobes indicated ...
(Date:5/25/2016)... , May 25, 2016  Zymo Research ... for their new reference materials that help researchers ... sample collection to analyses. The rapid growth of ... for researchers to have standard methods to improve ... generated. Biases inherently exist at every step of ...
(Date:5/25/2016)... 2016  Granger Diagnostics today announced immediate availability of ... infections. This test ensures discovery of ALL bacteria, ... test requires only a simple swab of the wound ... G. Bostwick , MD, Chief Medical Officer, described ... "We are excited to make available, for the ...
Breaking Medicine Technology: