Navigation Links
Vigorous Exercise Aids Those With Obesity-Related Gene
Date:9/8/2008

Effect of mutation blunted in people with above-average activity scores, study finds

MONDAY, Sept. 8 (HealthDay News) -- Physical activity may reduce the risk of obesity in people with a genetic mutation that predisposes them to high body-mass index (BMI), says a U.S. study.

Recent research has shown a link between BMI and variants of the fat mass and obesity associated with the (FTO) gene. The mutations connected with obesity occur in about 30 percent of European populations and are associated with a 1.75-kilogram (3.9-lb.) increase in body weight, according to background information in the study.

While lifestyle factors such as diet and exercise are important factors in weight control, it's not exactly clear how they interact with genetics.

In this study, researchers analyzed DNA samples from 704 healthy Amish adults, average age 43.6, and also conducted a series of physiological tests on the participants, including recording their physical activity over a seven-day period.

Among the participants, 54 percent of men and 63.7 percent of women were overweight, and 10.1 percent of men and 30.5 percent of women were obese. The genetic analysis showed that 26 single-nucleotide polymorphisms (SNPs -- changes in a single base letter of DNA) in the FTO gene were associated with BMI.

Further investigation found that the two strongest SNPs were associated with BMI only in people with low physical activity scores. The SNPs had no effect on people with above-average physical activity scores.

The study was published in the Sept. 8 issue of the Archives of Internal Medicine.

"Activity levels in the 'high-activity' stratum were approximately 900 calories [860 calories for women and 980 calories for men] higher than in the 'low-activity' stratum, which, depending on body size, corresponds to about three to four hours of moderately intensive physical activity, such as brisk walking, housecleaning or gardening," the researchers wrote.

"In conclusion, we have replicated the associations of common SNPs in the FTO gene with increased BMI and risk to obesity in the Old Order Amish. Furthermore, we provide quantitative data to show that the weight increase resulting from the presence of these SNPs is much smaller and not statistically significant in subjects who are very physically active. This finding offers some clues to the mechanism by which FTO influences changes in BMI and may have important implications in targeting personalized lifestyle recommendations to prevent obesity in genetically susceptible individuals."

More information

The U.S. National Heart, Lung, and Blood Institute has more about overweight and obesity.



-- Robert Preidt



SOURCE: JAMA/Archives journals, news release, Sept. 8, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Manor Care To Vigorously Contest TRO
2. More Sweat Equals Lower Risk of Exercise-Induced Asthma
3. Exercise May Help Prevent Age-Related Memory Loss
4. September 2008 Mayo Clinic Womens HealthSource Highlights Normal Weight Obesity, Regular Exercise and Cholesterol
5. Active Video Games Help Kids Exercise
6. Exercise Lowers Risk of Colon Cancer
7. Immigrant Children Less Likely to Exercise
8. Creatine Has Negligible Effect on COPD Exercise Rehab
9. No substitute for hard work: Creatine supplementation does not improve exercise outcomes in COPD
10. Exercise Testing for Cancer Fails to Follow Guidelines
11. Making patients move requires the right exercise advice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... STAMFORD, CONNECTICUT (PRWEB) , ... April 29, 2016 , ... ... 5K Run/Walk” at Cove Island Park on Sunday, with sunny skies, a light breeze ... event, raising nearly $33,000. , The 5k Run and Walk and 1-mile ...
(Date:4/29/2016)... Philadelphia, PA (PRWEB) , ... April 29, 2016 ... ... Pennsylvania announced that student team BioCellection won the $30,000 Perlman Grand Prize of ... Impact Prize, the Gloeckner Undergraduate Award, the Michelson People’s Choice Award, and the ...
(Date:4/29/2016)... ... ... is the deadliest type of skin cancer. Although only about 1 percent of skin cancer ... than 10,000 people are expected to die of melanoma this year. The risk increases with ... the most commonly diagnosed cancers in young women. A recent breakthrough in genetic studies may ...
(Date:4/29/2016)... ... April 29, 2016 , ... For those who skip ... meal to miss. That was among the many new lifestyle diet tips offered by ... Sharon Kleyne Hour® Power of Water® radio show. Bonny and Lawrence noted that because ...
(Date:4/29/2016)... ... April 29, 2016 , ... CURE Media Group , ... with cancer, today announced that Lynne Malestic, RN, of Eisenhower Lucy Curci Cancer ... Healer® for Oncology Nursing , which honors nurses who have dedicated their careers ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... 2016 Interview ... Sanofi, leader mondial et diversifié ... pour le premier trimestre 2016. Le ... commente les résultats du premier trimestre ... le reste de l,année. ...
(Date:4/28/2016)... , April 28, 2016  While Abbott,s ... complement the company,s valve repair and stent business, ... also places Abbott more firmly into patient monitoring.  ... the fastest growing device areas, with double-digit growth ... recent report,  Advanced Remote Patient Monitoring ...
(Date:4/28/2016)... , April 28, 2016  The blood testing ... million dollars, according to Kalorama Information and The Freedonia ... immunoassays and nucleic acid testing.  The healthcare research firm ... progress in developing blood collection stations and in improving ... in Kalorama Information,s report, Blood Testing Market ...
Breaking Medicine Technology: