Navigation Links
Video May Help Predict Which Embryos Will Survive IVF
Date:10/4/2010

By Jenifer Goodwin
HealthDay Reporter

MONDAY, Oct. 4 (HealthDay News) -- Using time-lapsed video to watch fertilized eggs grow may offer clues about which embryos have the best chances of resulting in pregnancy when using in vitro fertilization, Stanford researchers report.

Under current techniques, embryologists look for certain physical characteristics of the embryos at about Day 3 to decide which embryos are thriving and should be placed in the woman's uterus. That procedure usually occurs at around Day 5, when the embryo has reached the blastocyst stage, considered a critical stage of development that ups the chances of pregnancy.

However, research suggests that embryos grown outside of the mother's body may be susceptible to changes in gene expression that may raise the risk of some long-term health problems, said senior study author Renee Reijo Pera, director of the Center for Human Embryonic Stem Cell Research and Education at Stanford's Institute for Stem Cell Biology and Regenerative Medicine in Palo Alto, Calif.

The new technique, which uses imaging technology and a computer algorithm to observe and analyze the growth of embryos during the entire first three days, could help IVF practitioners choose the best embryos sooner, Pera said.

Being able to better predict which embryos will survive could ease the pressure on couples and their doctors to implant multiple embryos that can result in twins, triplets and higher order multiples, Pera said.

According to the study, the timing with which the embryo divides from one cell into multiple cells during the first three days can predict with 93 percent certainty which embryos will make it to the blastocyst stage, which indicates a healthy embryo.

The study is published in the Oct. 3 online issue of Nature Biotechnology.

With in vitro fertilization, the sperm and egg are joined outside the womb to form an embryo. Typically, IVF practitioners create several embryos, which are grown in a culture for three to five days.

At that point, an embryologist views the embryos under a microscope and selects those that look the healthiest for implantation.

Embryologists look for embryos that are plump and dividing regularly; embryos that are small, dark or irregular probably won't survive and attach to the lining of the uterus, Pera explained.

But the process of creating and choosing embryos is imperfect, Pera said. Many embryos don't survive beyond the first few days -- about 50 percent to 70 percent of embryos don't make it to the blastocyst stage, according to background information in the article.

Even for those that do, there's no guarantee of a pregnancy. Nationwide, the live birth rate for each IVF cycle is about 30 percent to 35 percent for women under 35, and drops as a woman's age increases, according to the American Pregnancy Association.

In the study, researchers filmed 242 one-cell human embryos that had been frozen and donated to medical research. Of those, 100 made it to the blastocyst stage at about Day 5.

'Movies' of the embryos developing showed that those most likely to make it to the blastocyst stage followed a similar pattern: it took about 15 minutes to complete the process of a single cell dividing into two cells; the third cell appeared between 7.8 and 14.3 hours; the fourth cell appeared shortly thereafter (within an hour).

"You want the third and fourth cells close together," Pera said. "If they are both healthy, you want them to be synchronous. If one lags, it's probably going to die."

An embryo that's made it to the blastocyst stage has a two- to threefold greater chance of resulting in a pregnancy, Pera said.

Watching the embryo as it grows and divides offers a more complete picture of its health than viewing the embryo only at a single point in time, Pera said. "How the embryo moves, when it divides, that's where the information is," Pera said.

Pera compared it to watching a person who is ill versus a healthy person walk. "If you watch a person who isn't well cross a road, you know they are not well," Pera said. "You can get all kinds of clues from the movement compared to when they are standing still."

Dr. David Smotrich, medical director of La Jolla IVF in La Jolla, Calif., said the research is promising.

"This is a very eloquent paper," Smotrich said. "If you are able to make this prediction early on, in theory you can choose which embryos to place much earlier and have a better understanding of the overall quality of the embryo and overall likelihood of it to implant."

Yet much more needs to be learned, Smotrich said. The study looked only at what happens to embryos up to about Day 5. Since none of the embryos were actually implanted, there's no way of knowing if the technique would improve IVF success rates.

The imaging technique itself also needs to be tested to make sure there's no risk of damaging the embryo, Smotrich said.

Auxogyn Inc., of Menlo Park, Calif., has licensed the technology from Stanford, and Pera said the next steps are clinical trials to determine if the screening method works outside of the lab.

More information

The U.S. National Library of Medicine has more on embryonic development.

SOURCES: Renee Reijo Pera, Ph.D., professor, obstetrics and gynecology, Stanford Medical School, and director, Center for Human Embryonic Stem Cell Research and Education, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Palo Alto, Calif.; David Smotrich, M.D., medical director, La Jolla IVF, La Jolla, Calif.; Oct. 3, 2010, Nature Biotechnology, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Video gaming prepares brain for bigger tasks
2. Too much TV, video and computer can make teens fatter
3. Action-Packed Video Games May Be Good for You After All
4. Video game processors help lower CT scan radiation
5. Wiley-Blackwell Conducts Trial of SciVee Video Platform
6. Videoconferencing with family members enriches the lives of nursing home residents
7. Video study finds risky food-safety behavior more common than thought
8. Reflection Golf - (Slow Motion Video) Announces National Launch at PGA Center for Golf Learning & Performance, Port St. Lucie, Florida.
9. North Carolina Film Student Scores Big in Bicycle Safety Video Contest
10. Judges Select Winner of the Ban Asbestos Now Video Search
11. Kantola Productions Releases Workplace Violence Prevention Training Video
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Video May Help Predict Which Embryos Will Survive IVF
(Date:6/26/2016)... ... 27, 2016 , ... Quality metrics are proliferating in cancer care, and are ... the eye of the beholder, according to experts who offered insights and commentary in ... Managed Care. For the full issue, click here . , For the American ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... ... fertility once they have been diagnosed with endometriosis. These women need a treatment ... also require a comprehensive approach that can help for preservation of fertility and ...
(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
(Date:6/24/2016)... Fla. (PRWEB) , ... June 24, 2016 , ... Global ... Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition ... Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this year’s ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... DUBLIN , June 27, 2016 Jazz ... the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act ... proposed acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... 11:59 p.m. (Eastern Daylight Time). As previously ... entered into a definitive merger agreement under which Jazz ...
(Date:6/24/2016)... June 24, 2016  Global Blood Therapeutics, Inc. (GBT) ... developing novel therapeutics for the treatment of grievous ... the closing of its previously announced underwritten public ... the public offering price of $18.75 per share. ... offered by GBT. GBT estimates net proceeds from ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
Breaking Medicine Technology: