Navigation Links
Video Illustrates New Columbia University Research: How Infections Attack Brains and Result in Devastating Neuropsychiatric PANDAS/PANS Symptoms

New research has discovered a previously unknown mechanism through which certain infections can impact the brain causing post infectious encephalitis. The work was conducted to determine if PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) and PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) could adversely attack the central nervous system and create brain inflammation as well. PANDAS and PANS cause devastating symptoms, which can include a sudden, dramatic onset of obsessive compulsive disorder, or severely restrictive food intake, together with severe anxiety, depression, tics, neurological conditions, sleep disturbances, and a host of other psychiatric behaviors.

PANDAS and PANS afflict roughly one in every 200 children in the U.S. The conditions are caused by an autoimmune reaction triggered by infections such as strep throat, walking pneumonia, viruses and Lyme disease, which result in inflammation of the child's brain.

Research conducted by Dr. Dritan Agalliu in the Department of Neurology at Columbia University Irving Medical Center, reveals that immune cells responding to strep throat bacteria and likely other infections can travel through nasal passages up into the brain area called the olfactory bulb, where they damage the blood-brain barrier in mice. Compromising that barrier — which is meant to keep molecules out of the brain that don’t belong there — allows autoantibodies to enter and inappropriately attack healthy brain cells and damage blood vessels. That attack causes neuroinflammation and neuronal dysfunction, leading to the abrupt onset of severe neurological and/or psychiatric symptoms.

Dr. Agalliu was investigating autoimmune encephalitis (AE), a group of central nervous system disorders. Specifically, he was probing the mechanisms that cause post-infectious basal ganglia encephalitis (BGE) disorders, a subset of AE that is triggered by either bacterial, viral or fungal infections. The basal ganglia are in an area of the brain associated with regulating functions such as motor movement, cognitive and emotional response, and procedural learning.

“The loss of taste and smell in BGE patients was an unexpected clue,” said Diana Pohlman, director of the nonprofit PANDAS Network. “Dr. Agalliu’s innovation shows how the antibodies get into the brain, using previously undiscovered mechanisms in the olfactory system.”

In honor of the children and adults who have suffered from AE, the PANDAS Network sponsored the development of an animated video — “How Immune Response to Infection Triggers Basal Ganglia Encephalitis Through the Breakdown of the Blood-Brain Barrier” — to illustrate the mechanism discovered by Dr. Agalliu’s research.

“As we explain in the video, early diagnosis and treatment is imperative for this complex patient population,” added Pohlman. “We hope this video helps healthcare providers better understand the neurological processes causing the disturbing and confusing symptoms these patients often present with that are often misdiagnosed, which can include crippling OCD, tics, inability to eat and in some cases periods of intense seizure-like rage and breaks from reality.”

The free video is available for viewing online here.

This research was funded by a RO1 Grant from the National Institute of Mental Health.

About PANDAS Network
PANDAS Network is dedicated to improving the diagnosis and treatment of children with PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) and PANS (Pediatric Acute-onset Neuropsychiatric Syndrome). Armed with an impressive network of doctors, researchers and scientists, PANDAS Network strives to collaborate with subject matter experts, build public awareness, provide family support, and gather data and resources to better inform parents and the medical community about PANDAS and PANS. To learn more or donate, visit

Read the full story at

Source: PRWeb
Copyright©2020 Vocus, Inc.
All rights reserved

Related medicine news :

1. How Untreated Hyperglycemia Can Lead to Kidney Failure and Disease Discussed in New Video From Health Nutrition News
2. Promoting chemistry through cooking: American Chemical Society Prized Science video
3. Phoenix Treatment Center Announces New Video Explaining Its Services for Drug, Alcohol Addiction
4. San Antonio Alcohol Rehab Presents New Video Regarding Its Services and Consultations for Adults, Adolescents
5. San Jose Drug Rehab Launches Video on Services for People Seeking Help with Drug Addiction
6. Wichita Drug Rehab Announces New Video Explaining Services Offered Through Drug Addiction Treatment Centers
7. Cleveland Treatment Center Launches Video Detailing Its Services for Drug, Alcohol Recovery
8. Infertility Meets Social Media in a Virtual Video Contest to Win a Donated IVF Cycle
9. Movember Team "The Hot TomAli's" Launch Music Video to Change the Face of Men's Health
10. New Best Drug Rehabilitation Video Features CEO Per Wickstrom Interviewing Dr. John R. Trotter II on Increasing Prescription Opiate Abuse
11. Expert San Diego Dermatologist Discusses Non-Invasive Botox for Crow's Feet and Forehead Wrinkles in New Video
Post Your Comments:
(Date:6/28/2020)... ... 26, 2020 , ... Medisend College of Biomedical Engineering Technology, ... training that prepares graduates for professional careers as field service engineers and biomedical ... Trustees. , Ms. Williams currently serves as Associate Vice Chancellor of Workforce and ...
(Date:6/28/2020)... ... June 27, 2020 , ... The secret of surviving a pandemic ... rolls of toilet paper. Yet, it was the first product to disappear off the ... The more you have stockpiled, the less need to venture out, the longer you ...
(Date:6/25/2020)... ... June 25, 2020 , ... Denials Management, Inc. has just published ... steps when filing appeals for denials of mental health and substance use disorder (MH/SUD) ... about their appeal rights and explain the steps in the appeals process. Complimentary ...
(Date:6/24/2020)... ... June 24, 2020 , ... SPH Analytics , ... Physician Hospital Organization (PHO) has successfully deployed SPH’s Population Care™ all-payer population health ... value-based care. Use of Population Care is benefitting more than 77,000 patients covered ...
(Date:6/23/2020)... ... June 23, 2020 , ... Oak Street Health, a network of primary ... for nationwide expansion in 2020 with the company’s first centers in New York and ... in Brooklyn, N.Y., and a new center in Jackson, Miss. , “The planned ...
Breaking Medicine News(10 mins):
(Date:6/23/2020)... (PRWEB) , ... June 23, ... ... ("Lighthouse" or the "Company"), a leading provider of center-based, Applied Behavioral Analysis ... a rapidly-growing, center-based ABA provider in the greater-Indianapolis market. This acquisition will ...
(Date:6/23/2020)... ... June 23, 2020 , ... Construction at the ... now features a greatly enlarged and enhanced medical facility. Penetron crystalline technology ... tanks, and rooftop garden. , Part of the Bangkok Chain Hospital (BCH) network ...
(Date:6/19/2020)... Mo. (PRWEB) , ... June 19, 2020 , ... ... end hunger in individuals diagnosed with food allergies and celiac disease announced the first ... Allergy. , This webinar is scheduled for Friday, June 19, 2020, from 11:00, ...
Breaking Medicine Technology: