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Video: The MDS Foundation Says Published Data Confirms VIDAZA(R) Significantly Extends Survival in Patients with the Malignant Condition MDS
Date:2/18/2009

VIDAZA Restores Gene Function to Double Survival and Increase Transfusion Independence

CROSSWICKS, N.J., Feb. 18 /PRNewswire/ -- The Myelodysplastic Syndromes (MDS) Foundation says data published in the peer reviewed medical journal The Lancet Oncology confirms VIDAZA extends survival for patients with higher-risk MDS. Myelodysplastic syndromes are a group of blood-related malignancies that are difficult to treat and in higher-risk patients have a median survival rate of less than one year. Symptoms include anemia and fatigue, and often patients must rely on blood transfusions to manage the symptoms. VIDAZA, also known by its chemical name, azacitidine, represents a new approach to treatment with important benefits for patients with MDS, and a related condition called acute myeloid leukemia (AML).

To view the Multimedia News Release, go to: http://www.prnewswire.com/mnr/mds-foundation/37124/

"The data from this large international study of VIDAZA is important news for the patients we represent, validating a new treatment option and offering tangible results for this difficult-to-treat disease," said Kathy Heptinstall, Operating Director of the Myelodysplastic Syndromes Foundation.

"VIDAZA was able to essentially double survival at two years compared to conventional care," says Lewis Silverman, M.D., of Mount Sinai Medical Center in New York and senior study author. "VIDAZA is the first and only drug that we know extends survival."

In MDS, genes responsible for orderly growth and development of cells in the bone marrow are turned off or silenced, allowing the cells to become malignant. VIDAZA turns these genes back on through a system of actions called epigenetics, a new approach to cancer treatment. It is also the first drug to achieve transfusion independence in more than 40%
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SOURCE The Myelodysplastic Syndromes Foundation
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