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Video: Phase III Head to Head Trial Showed Ticagrelor Reduced Cardiovascular Death and Heart Attacks Over Clopidogrel in Acute Coronary Syndromes Patients
Date:8/29/2009

rdiovascular event, so preventing reoccurrence is vital in ACS patient treatment."

The PLATO results have confirmed AstraZeneca's intention to submit the NDA and MAA with regulatory agencies during the fourth quarter of this year.

PLATO was a head-to-head 18,624 patient outcomes study of ticagrelor plus aspirin versus the active comparator, clopidogrel plus aspirin, and was designed to establish whether ticagrelor could achieve meaningful cardiovascular and safety endpoints in ACS patients. Given the size of the PLATO database, we will continue to analyse and publish additional PLATO findings.

About AstraZeneca

AstraZeneca is a major international healthcare business engaged in the research, development, manufacturing and marketing of meaningful prescription medicines and supplier for healthcare services. AstraZeneca is one of the world's leading pharmaceutical companies with healthcare sales of US$ 31.6 billion and is a leader in gastrointestinal, cardiovascular, neuroscience, respiratory, oncology and infectious disease medicines. For more information about AstraZeneca, please visit: www.astrazeneca.com.

Notes to Editors:

Primary results from the PLATO study were presented today at the European Society of Cardiology annual meeting in Barcelona, Spain and simultaneously published in the online version of the New England Journal of Medicine (NEJM), www.nejm.com.

About BRILINTA(TM)

Ticagrelor (BRILINTA(TM)) is an investigational oral antiplatelet treatment for ACS. BRILINTA (ticagrelor) is the first reversibly binding oral adenosine diphosphate (ADP) receptor antagonist. It selectively inhibits P2Y12, a key target receptor for ADP. ADP rec
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