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Video: Phase III Head to Head Trial Showed Ticagrelor Reduced Cardiovascular Death and Heart Attacks Over Clopidogrel in Acute Coronary Syndromes Patients
Date:8/29/2009

001) but did not represent new or worsening heart failure or lung disease. Only one in 100 ticagrelor patients overall stopped taking study medication due to dyspnoea.

PLATO analyzed 66 subgroups (33 efficacy and 33 safety subgroups). Thirty of the 33 efficacy subgroups analyzed were consistent with the analysis of efficacy in the overall population; showing a benefit for ticagrelor over clopidogrel. Of the three remaining subgroups, one (patients with weight below the gender-specific median) showed an attenuated benefit for ticagrelor over clopidogrel. The other two subgroups (patients not taking a statin medication on the day of randomization and those at sites in North America) showed no treatment advantage for ticagrelor.

Of the 33 safety subgroups analyzed, 32 were consistent with the analysis of safety in the overall population; showing no statistically significant difference between ticagrelor and clopidogrel. The remaining subgroup (patients with a Body Mass Index BMI > 30kg/m2) had major bleeding more frequently with ticagrelor than with clopidogrel.

Given the large number of tests performed these differences may have been due to chance. The observed difference in results between patients in North America and those enrolled elsewhere raises questions of whether geographic differences between populations of patients or practice patterns influenced the effects of the randomised treatments, although no apparent explanations have been found to date.

"As a cardiology community, we are constantly seeking rigorously studied options to offer our patients who are facing an increased risk of serious, and potentially deadly, complications," said Robert A. Harrington, M.D., co-chair of the PLATO Executive Committee, Duke Clinical Research Institute. "An estimated one in three ACS patients will die, have a recurrent heart attack or be readmitted to hospital within six months of their first ca
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SOURCE AstraZeneca
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