Navigation Links
Vicious cycle: Obesity sustained by changes in brain biochemistry
Date:5/16/2013

PROVIDENCE, R.I. [Brown University] With obesity reaching epidemic levels in some parts of the world, scientists have only begun to understand why it is such a persistent condition. A study in the Journal of Biological Chemistry adds substantially to the story by reporting the discovery of a molecular chain of events in the brains of obese rats that undermined their ability to suppress appetite and to increase calorie burning.

It's a vicious cycle, involving a breakdown in how brain cells process key proteins, that allows obesity to beget further obesity. But in a finding that might prove encouraging in the long term, the researchers at Brown University and Lifespan also found that they could intervene to break that cycle by fixing the core protein-processing problem.

Before the study, scientists knew that one mechanism in which obesity perpetuates itself was by causing resistance to leptin, a hormone that signals the brain about the status of fat in the body. But years ago senior author Eduardo A. Nillni, professor of medicine at Brown University and a researcher at Rhode Island Hospital, observed that after meals obese rats had a dearth of another key hormone alpha-MSH compared to rats of normal weight.

Alpha-MSH has two jobs in parts of the hypothalamus region of the brain. One is to suppress the activity of food-seeking brain cells. The second is to signal other brain cells to produce the hormone TRH, which prompts the thyroid gland to spur calorie burning activity in the body.

In the obese rats alpha-MSH was low, despite an abundance of leptin and despite normal levels of gene expression both for its biochemical precursor protein called pro-opiomelanocortin (POMC) and for a key enzyme called PC2 that processes POMC in brain cells. There had to be more to the story than just leptin, and it wasn't a problem with expressing the needed genes.

Nillni and his co-authors, including lead authors Isin Cakir and
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
2. Obesitys Health Costs Double Earlier Estimates
3. Troubled Homes May Fuel Obesity in Girls
4. Childhood Obesity May Raise Odds of Adult Liver Cancer
5. Could the Childhood Obesity Epidemic Be Ebbing?
6. New research finds no association between white potato consumption (baked, boiled mashed) and obesity, Type 2 diabetes or systemic inflammation
7. Mayo Clinic: Obesity epidemic fueling rise in rheumatoid arthritis among women
8. Treating childhood obesity: A family affair
9. Rising Obesity Rates Might Mean More Rheumatoid Arthritis
10. Research May Point to New Obesity Treatments
11. U.S. Obesity Rate Set to Soar, Costing Billions: CDC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... City, NY (PRWEB) May 05, 2015 ... honors Patti Hommes as a 2015-2016 inductee ... is recognized with this prestigious distinction for leadership in ... for professional women, boasting more than 700,000 members and ... recognize Patti with this important honor,” says NAPW President ...
(Date:5/4/2015)... 04, 2015 Every Friday afternoon at ... located in Southwest Michigan, patients and staff gather in ... graduating the rehabilitation program and to gain encouragement and ... , One by one, those patients who have ... accept their certificates and to share a bit about ...
(Date:5/4/2015)... HHT is a rare but cruel and ... can have seemingly mild symptoms like frequent nosebleeds, it ... Hemorrhagic Telangiectasia (HHT) is a hereditary disorder resulting in ... connections between an artery and a vein. These abnormalities ... may also be present in the lungs, brain and ...
(Date:5/4/2015)... 04, 2015 Takeda Pharmaceuticals Corp. has ... settle thousands of Actos lawsuits ( http://www.theactoslawsuitcenter.com/ ) ... risk that a patient will develop bladder cancer. According ... 95% of those eligible for the Actos settlement accept ... cancer cases currently pending in courts around the country, ...
(Date:5/4/2015)... “ LiveSchool ” was featured on NewsWatch ... look at the latest and coolest applications on the ... host of AppWatch and technology expert, conducted the app ... teachers to reward students with good behavior. , Positive ... the classroom. And the good people at LiveSchool ...
Breaking Medicine News(10 mins):Health News:NAPW Inducts Patti Hommes, Director of Advancement Services, Springside Chestnut Hill Academy, a 2015-2016 Professional Woman of the Year Circle 2Health News:A Forever Recovery Celebrates New Victories in Overcoming Addiction With Weekly Graduation 2Health News:Frequent Nosebleeds Can Be a Sign of a Rare Undiagnosed Disease - Cure HHT 2Health News:Frequent Nosebleeds Can Be a Sign of a Rare Undiagnosed Disease - Cure HHT 3Health News:Actos Lawsuit Settlement: Takeda Pharmaceutical Co. to Pay As Much As $2.4 Billion to Resolve Claims Alleging Actos Causes Bladder Cancer 2Health News:Actos Lawsuit Settlement: Takeda Pharmaceutical Co. to Pay As Much As $2.4 Billion to Resolve Claims Alleging Actos Causes Bladder Cancer 3Health News:An Application for Teachers to Reward Students with Good Behavior Was Featured on NewsWatch Television 2
... According to the National Cancer,Institute, 1 in 8 ... 40,000 women will die of breast cancer in the ... lung cancer as the leading cause of cancer,deaths in ... Carole Aydell has heard,countless excuses for why women refuse ...
... (NYSE: SRZ ) today announced the appointment of ... March 19, 2008., Prior to joining Sunrise, Mr. ... The Mills Corporation, where he oversaw the eventual sale ... May 2007. Previously, he,founded and was Chief Executive Officer ...
... IT in, Support of Federal Agencies and Healthcare Providers Will ... ... CHURCH, Va., March 20 Harris,Corporation (NYSE: HRS ), ... contract by the U.S. Department of,Health and Human Services to ...
... phone survey conducted among 1,000 allergy sufferers, 1,000 consumers ... that beyond the sneezing, sniffling and watery eyes, allergies ... mood and self-perceptions. , According to Attitudes ... allergies affect their mood. 51 percent of sufferers ...
... Certified asthma & allergy friendly(TM) by the Asthma, and Allergy Foundation ... ... to More Consumers, ENGLEWOOD CLIFFS, N.J., March 20 ... help those suffering from,common household allergies, LG Electronics today announced the ...
... GREENSBORO, N.C., March 20 Acting U.S.,Surgeon General Rear ... adolescent overweight and obesity to members of the Society ... in Greensboro,NC next week. Dr. Galson will speak on ... to nearly 500 SAM members. In early March Dr. ...
Cached Medicine News:Health News:Make Your Mammogram a Positive Experience: Author Offers Guidelines and Tips to Change Women's Negative Attitudes Toward Mammograms 2Health News:Sunrise Senior Living Names Mark Ordan Chief Investment and Administrative Officer 2Health News:Sunrise Senior Living Names Mark Ordan Chief Investment and Administrative Officer 3Health News:Harris Corporation Awarded Contract to Develop National Health Information Exchange Gateway for Sharing Patient Records 2Health News:New survey shows allergies dramatically impact sufferers' moods and how they feel about themselves 2Health News:LG Electronics Debuts Unique Allergen-Reducing Steam Washer/Dryer Combo 2Health News:LG Electronics Debuts Unique Allergen-Reducing Steam Washer/Dryer Combo 3Health News:LG Electronics Debuts Unique Allergen-Reducing Steam Washer/Dryer Combo 4Health News:Acting U.S. Surgeon General to Speak to Society for Adolescent Medicine on Prevention of Adolescent Overweight and Obesity 2Health News:Acting U.S. Surgeon General to Speak to Society for Adolescent Medicine on Prevention of Adolescent Overweight and Obesity 3
(Date:5/4/2015)... N.J. , May 4, 2015 Thirty-six ... percent seek help. During May – National Hearing Month ... loss could be missing out on the sounds of ... the trees. To ensure that you won,t ... that color our world, Oticon, Inc. offers practical advice: ...
(Date:5/4/2015)... 2015  Impax Laboratories, Inc. (NASDAQ: IPXL ) ... roles, appointing  Donna M. Hughes, as Senior Vice President, ... Senior Vice President, Chief Compliance Officer. Both Ms. Hughes ... Chief Executive Officer, Fred Wilkinson . ... the Impax team," said Fred Wilkinson , President ...
(Date:5/4/2015)... Bayer HealthCare (Bayer) has entered into an ... ISIS ) on ISIS-FXI Rx, an antisense investigational ... Under the agreement Bayer will further develop and commercialize ... need. As part of the clinical development program, Bayer ... in an appropriate patient community. "Bayer ...
Breaking Medicine Technology:It's Better Hearing Month 2Impax Strengthens Leadership Team by Adding New Senior Vice Presidents for Human Resources and Compliance 2Impax Strengthens Leadership Team by Adding New Senior Vice Presidents for Human Resources and Compliance 3Bayer Licenses Investigational ISIS FXI(Rx) from Isis Pharmaceuticals to Develop and Commercialize for the Prevention of Thrombosis 2Bayer Licenses Investigational ISIS FXI(Rx) from Isis Pharmaceuticals to Develop and Commercialize for the Prevention of Thrombosis 3
... Jan. 3, 2011 The MED Group, a Managed ... of www.medicaresuppliersnetwork.com .  The website was created to ... such as physician offices, about competitive bidding and how ... program. The Centers for Medicare and Medicaid ...
... Boston Scientific Corporation (NYSE: BSX ) ... its Neurovascular business to Stryker Corporation.  The sale price ... at closing (including an upfront payment of $1.376 billion, ... of the next-generation Target™ Detachable Coils, and $24 million ...
Cached Medicine Technology:New Program for Medicare Beneficiaries Will Mean Major Changes Effective January 1, 2011 - Ohio 2New Program for Medicare Beneficiaries Will Mean Major Changes Effective January 1, 2011 - Ohio 3Boston Scientific Completes Sale of Neurovascular Business 2Boston Scientific Completes Sale of Neurovascular Business 3Boston Scientific Completes Sale of Neurovascular Business 4
BD Persist Plus protective barrier provides a one-step antimicrobial barrier with minimum of 1% chlorhexidine with Up to 7-day antimicrobial effectiveness....
The design of the new ChloraPrep swabstick applicator provides significant improvement in performance over traditional swabsticks....
... Swabsticks are packaged in easy open, single-use ... saturated with precisely the correct amount of ... the safest possible product for the patient. ... an excellent combination of ethyl alcohol and ...
... provides 5% povidone-iodine solution ... It delivers a microbicidal ... tender to touch. It ... indicated whenever effective microbicidal ...
Medicine Products: