Navigation Links
Viagra Trial for Sickle Cell Lung Problems Halted
Date:7/28/2009

Safety concern from side effects prompts action by U.S. government

TUESDAY, July 28 (HealthDay News) -- The first clinical trial of a treatment for pulmonary hypertension in adults with sickle cell anemia has been stopped because of severe side effects in some participants.

The trial involved sildenafil -- marketed as Viagra when it is used to treat erectile dysfunction and Revatio when used for pulmonary arterial hypertension, or high blood pressure in the lungs.

"This was a very big disappointment," said Dr. Mark Gladwin, lead investigator of the study, which was sponsored by the U.S. National Heart, Lung, and Blood Institute. "We were very excited about this drug. It has a very high safety profile and has worked in every form of pulmonary hypertension. The preliminary data showed a lowering in pulmonary hypertension in sickle cell patients."

Pulmonary hypertension affects as many as 30 percent of people with sickle cell disease. "It's the highest risk of death, so it's a very important complication," said Gladwin, who is director of the Vascular Medicine Institute at the University of Pittsburgh.

People with sickle cell disease have an average of two so-called "crises" a year, involving severe pain and often requiring hospitalization. The crises occur when red blood cells, which are misshaped in those with the disease, get jammed up in the blood vessels, blocking blood flow.

An estimated 70,000 to 100,000 people in the United States have this genetic blood disorder, most of them black.

According to the institute, there are no current guidelines for treating pulmonary hypertension in people with sickle-cell disease, although drugs known as endothelin receptor blockers are sometimes used. The condition can lead to heart failure and death.

A small pilot trial using Revatio and involving just 12 people with sickle cell anemia had found a decrease in pulmonary hypertension.
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. After 10 Years A Stronger and More Enhanced Form of Viagra Now Available
2. Video: Bathmate Hydropump Poised to Replace Cialis, Levitra, and Viagra
3. Rapid Generic Erosion of Branded Agents, Including Market-Leading Viagra, Will Cause Sales of Erectile Dysfunction Drugs to Remain Flat Over the Next Decade
4. Viagra May Shield Heart From Blood Pressure Damage
5. Viagra Bulk Effectively Cures Children with PAH (Pulmonary Arterial Hypertension)
6. For Patients Who Fail on Viagra, Levitra or Cialis
7. Viagra May Protect Hearts of Some Muscular Dystrophy Patients
8. TriMix-gel vs Viagra, Levitra, Cialis Data to Be Presented at AUA
9. AUDIO from Medialink and Pfizer: Viagras 10th Anniversary
10. An Important Message to Anyone Taking Viagra ... From The Women Who Love You ... and Zoller Labs
11. MULTAQ(R) (dronedarone) for Atrial Fibrillation or Atrial Flutter Now Available in the United States
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Viagra Trial  for Sickle Cell Lung Problems Halted
(Date:3/29/2015)... Final Cut Pro X plugin ... Studios, entitled TranSports. , “TranSports is a compilation ... Pro X,” said Christiana Austin, CEO of Pixel Film ... effortlessly transition using this cool sports transition tool.” , ... styled transition pack for Final Cut Pro X. TranSports ...
(Date:3/28/2015)... March 28, 2015 Could genetic code ... new study by researchers at the Harvard ... with the support of the Coffee and Caffeine Genetics ... Psychiatry this past fall, the study—one of several recent ... genomic data from more than 120,000 regular coffee drinkers ...
(Date:3/28/2015)... The California-based leading wig brand UniWigs has prepared a ... during the Easter Holidays from today until April 6th. ... Fools’ Day. , As the winter fades and spring ... Festival, with religious origins to countries in Europe and ... The best wig provider, UniWigs, would like to offer ...
(Date:3/28/2015)... NV (PRWEB) March 28, 2015 Pitching speed, ... a history of shoulder and elbow injuries, according to new ... Medicine’s ( AOSSM ) Specialty Day. , “Our findings indicate ... a 20% increase in likelihood of a history of injury, ... with a 12% increase likelihood of a history of injury, ...
(Date:3/28/2015)... Raleigh, NC (PRWEB) March 28, 2015 ... people with peritoneal mesothelioma, revealing, for the first time, ... Click here to read the newly posted story ... scientists at the University of British Columbia, the British ... used genome mapping to reveal underlying molecular alterations and ...
Breaking Medicine News(10 mins):Health News:Introducing TranSports for Final Cut Pro X Users from Pixel Film Studios 2Health News:How Coffee Habits Relate to Our Genetic Code and Enhancing the Caffeine Experience 2Health News:How Coffee Habits Relate to Our Genetic Code and Enhancing the Caffeine Experience 3Health News:UniWigs Is Sending Out Mysterious Gifts During the Easter Holidays 2Health News:Researchers Highlight Shoulder and Elbow Injury Possibility in Youth Players 2Health News:New Genomics Research May Help Doctors Tailor Mesothelioma Treatment, According to Surviving Mesothelioma 2
... The increase in the number of U.S. medical students ... sign toward easing the primary care workforce shortage, according ... second-largest doctors group. The 2011 National Resident Matching ... from last year, with 2,940 U.S. seniors at medical ...
... Arbor, Mich. Providing kidney transplants to patients with ... transplant operations and improve life span after kidney transplant, ... the New England Journal of Medicine March 16., Alan ... and his co-authors endorsed new concepts designed to improve ...
... N.J. (March 16, 2011) The Multiple Myeloma Research ... Hackensack University Medical Center, member of the Multiple Myeloma ... in Multiple Myeloma Patient Symposium on Saturday, April 2 ... program is for patients and caregivers who want to ...
... released new official clinical guidelines on the diagnosis ... statement replaces ATS guidelines published in 2000, and ... and management of IPF, as well as available ... palliative care. , The statement appears in the ...
... By Maureen Salamon HealthDay Reporter , ... on Parkinson,s disease patients significantly improved the tremors, rigidity ... the illness, a small new study reports. The ... advanced Parkinson,s disease, with half randomly assigned to receive ...
... shows that it is feasible to screen for undiagnosed ... arrest (SCA). Adding a 10-minute electrocardiogram (EKG or ECG) ... of potentially serious heart conditions. Although more ... relatively low-cost screening might help identify children who are ...
Cached Medicine News:Health News:Residency match results encouraging for adults needing primary care 2Health News:Survival matching should be used to allocate donated kidneys to transplant recipients 2Health News:Survival matching should be used to allocate donated kidneys to transplant recipients 3Health News:The MMRF and John Theurer Cancer Center to host patient symposium 2Health News:ATS issues joint statement on the treatment of idiopathic pulmonary fibrosis 2Health News:ATS issues joint statement on the treatment of idiopathic pulmonary fibrosis 3Health News:ATS issues joint statement on the treatment of idiopathic pulmonary fibrosis 4Health News:Gene Therapy May Help Reverse Parkinson's Symptoms 2Health News:Gene Therapy May Help Reverse Parkinson's Symptoms 3Health News:In pilot study, screening detects potentially serious heart conditions in healthy children 2
(Date:3/27/2015)... March 27, 2015 XRpro Sciences, Inc., ... discovery and development services which features high throughput ... industry, announced financial results for the year ended ...  Tyson, Chairman of XRpro Sciences commented, "We have ... from development stage to commercial stage in large ...
(Date:3/27/2015)... March 27, 2015 According to ... (Diagnostic Catheter (Conventional, Advanced, Ultrasound), Ablation Catheter (Cryoablation, RF, ... Indication (AF, VT, WPW) - Global Forecasts to 2019 ", ... to reach around ~$4.73 Billion by 2019 with a ... to 2019. Browse   90   ...
(Date:3/27/2015)... Mass. , March 27, 2015 /PRNewswire/ ... and privately-held MirImmune LLC, today announced that ... agreement to RXi,s novel and proprietary sd-rxRNA® ... cancer immunotherapies. The collaboration has the potential ... patient friendly cancer treatments that could be ...
Breaking Medicine Technology:XRpro Sciences Announces Fiscal 2014 Financial Results 2XRpro Sciences Announces Fiscal 2014 Financial Results 3XRpro Sciences Announces Fiscal 2014 Financial Results 4Electrophysiology (EP) Market Worth $4.73 Billion by 2019 2Electrophysiology (EP) Market Worth $4.73 Billion by 2019 3Electrophysiology (EP) Market Worth $4.73 Billion by 2019 4RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 2RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 3RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 4RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 5
5mm from bend to tip 0.3x2.0mm Tip, Oblong 2 Sided Straight, at 45 degrees; In Titanium...
Angled 40 Degrees, 0.6x0.8 Elliptical Tip; in Titanium...
Double ended with 0.5mm x 10mm and 1.0mm x 15mm blades; both blades gently curved; round serrated handle, In Titanium....
Bend with "H" Shaped Tip, LEFT; in Titanium....
Medicine Products: