Navigation Links
Viagra May Protect Hearts of Some Muscular Dystrophy Patients
Date:5/12/2008

In study with mice, drug prevented heart failure in those with Duchenne muscular dystrophy

MONDAY, May 12 (HealthDay News) -- Patients with Duchenne muscular dystrophy often suffer from heart failure, but Viagra might prevent or delay the onset of this condition, a new Canadian study finds.

In experiments with mice, researchers showed that Viagra (sildenafil) improved heart performance by preventing the breakdown of a compound called cGMP, which relaxes smooth muscle.

"Duchenne muscular dystrophy is a crippling disease that affects both skeletal muscle and cardiac muscle," said lead researcher Christine Des Rosiers, a professor of cardiology in the department of nutrition at the University of Montreal. "Currently, there is a need for the development of more effective treatment strategies for patients affected with this disease."

In their experiments, the researchers used mice bred to mimic Duchenne muscular dystrophy. Then the scientists gave the rodents doses of Viagra comparable to those taken by men for erectile dysfunction.

The researchers found that Viagra improved heart function in the mice by preventing the breakdown of cGMP.

In a further experiment, the researchers inserted a gene into the hearts of the mice that increased the production of cGMP. The result: The mice were able to maintain normal heart function.

The findings are published in this weeks issue of the Proceedings of the National Academy of Sciences.

"Our findings substantiate benefits for the dystrophic heart using a pharmacological approach, namely with sildenafil, which is safe, well-tolerated and currently available for clinical use," Des Rosiers said. "Hence, this could provide the basis for a new avenue for the treatment. Furthermore, the benefits of this therapeutic approach would be expected to extend beyond the heart to affected skeletal muscle and other tissues."

Dr. Valerie A. Cwik, medical director and vice president of research at the Muscular Dystrophy Association, said there's a need for new approaches to the treatment of heart failure in patients with Duchenne and other forms of muscular dystrophy.

"The findings presented by these authors are interesting and certainly have potential clinical implications for the various forms of dystrophinopathy [heart damage]," she said, adding that heart failure is a major cause of illness and death in late-stage Duchenne muscular dystrophy.

"At the present time, there is no consensus or standard of care for optimal management of the cardiac complications of dystrophinopathies, and further research in this area is clearly needed," Cwik said.

While Viagra hasn't been tested in humans to see if it benefits muscular dystrophy patients, it has been available for years and appears to be safe, Cwik noted.

More information

For more on muscular dystrophy, visit the Muscular Dystrophy Association.



SOURCES: Christine Des Rosiers, Ph.D., professor, department of nutrition, University of Montreal, Canada; Valerie A. Cwik, M.D., medical director and vice president, research, Muscular Dystrophy Association, Tucson, Ariz.; May 13-16, 2008, Proceedings of the National Academy of Sciences


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. An Important Message to Anyone Taking Viagra ... From The Women Who Love You ... and Zoller Labs
2. AUDIO from Medialink and Pfizer: Viagras 10th Anniversary
3. TriMix-gel vs Viagra, Levitra, Cialis Data to Be Presented at AUA
4. Survey reveals disparities in skin cancer knowledge, protection among high school students
5. Scientists Develop Natural Protection for Stored Foods
6. Despite overeating, morbidly obese mice gain protection against diabetes
7. Daily Calcium Does Protect Bone
8. Tennessee Faith Leaders Call on Reps. Gordon & Blackburn to Co-sponsor Legislation to Protect Kids from Tobacco
9. Physician Skin Care Specialist Says Proposed New Rules for Sunscreen Products Will Better Protect the Public
10. Leading Child Abuse Center Releases Back to School Tips to Protect Children From Internet Predators
11. Breastfeeding does not protect against asthma, allergies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... Vighter established its NAEMT ... by providing Prehospital Trauma Life Support (PHTLS) course scholarships to four medics assigned ... education developed in cooperation with the American College of Surgeons to promote critical ...
(Date:3/24/2017)... ... March 24, 2017 , ... The Radiology Business Management Association (RBMA) ... annual awards, now in their 12th year, are among the most prestigious in radiology ... 2016, the awards were retooled to recognize achievements in both large budget (over $5,000) ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... and related services to families and business owners across eastern Michigan, is connecting ... regional families struggling with financial difficulties. , The Oxford/Orion FISH Food Pantry works ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... that they are now offering treatments for sleep apnea and TMJ at their ... Sleep apnea , specifically the obstructive type, is increasingly being treated at ...
(Date:3/24/2017)... ... March 24, 2017 , ... Gastro Health (“GH”) ... prep patients for colonoscopy at the HyGIeaCare® Center that is to be located ... , The HyGIeaCare® Prep, cleared by the U.S. Food and Drug ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... 24, 2017 The Board of Directors of ... Report 2016 including the complete 2016 Annual Accounts with notes. ... Nordic Nanovector,s website in the section Investor Relations/Reports and presentations/Annual ... ... Kvåle, Chief Financial Officer Cell: +47-91-51-95-76 Email: ir@nordicnanovector.com ...
(Date:3/23/2017)... Research and Markets has announced the addition ... Replacement Procedure By Technique, Repair Procedure By Technique, By Region, By ... ... forecasted to grow at a CAGR of 13.35% during 2016-2021 ... rising aging population, growth in population with heart disease and rising ...
(Date:3/23/2017)... , March 23, 2017 As ... years along with the prevalence of allergic diseases, ... measures are currently revolutionising the ways in which ... Allergies 2017 promises to be both a ... amongst the allergy interest groups, immunologists, research scholars ...
Breaking Medicine Technology: