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Viable Swine Flu Shot Closer to Reality
Date:5/25/2009

wine flu vaccine, the AP reported. The funding is aimed at pilot testing of a vaccine and the setting up of a "pre-pandemic" stockpile that HHS said would cover at least 20 million people, including health-care workers and people at high risk for complications from the illness.

In related news, a study released on Friday suggests that many of the genes that make up the new H1N1 swine flu virus have been circulating undetected in pigs for more than a decade.

Scientists at the CDC and elsewhere sequenced the genomes of dozens of samples of the swine flu strain and found it is distantly connected to its closest viral relatives.

The researchers also found that the new H1N1 strain lacks genes that -- in other influenza A strains -- confer ease of transmission and virulence.

CDC officials discussed the findings at a teleconference Friday. The findings were released early in the journal Science because of the broad interest in this new strain of swine flu.

"From our analysis, we have confirmed that the novel H1N1 virus likely originated from pigs, based on data that each of the genetic components of this virus are most closely related to corresponding influenza virus genes identified from swine influenza viruses," said Dr. Nancy Cox, chief of CDC's Influenza Division.

However, this new virus is not similar to seasonal H1N1 viruses, she said. In their analysis of 70 samples of the new H1N1 virus from the United States and Mexico, the researchers found minor genetic differences, but consider the virus to be basically homogeneous, Cox noted.

Knowing the genetic makeup of the virus makes it easier to come up with a candidate vaccine, Cox said. "We see much less variation among these new H1N1 viruses than we do for typical seasonal influenza viruses," she said.

Sequencing the virus' genetic code is also important for planning the public health response, including knowing which antivir
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