Navigation Links
Veterinary researchers study poultry virus as human cancer treatment
Date:2/12/2008

Blacksburg, Va. -- Researchers on the Blacksburg and College Park, Md., campuses of the Virginia-Maryland Regional College of Veterinary Medicine have been awarded a major new grant from the National Institutes of Health to support innovative work that seeks to develop a treatment for cancer from a common avian virus.

The National Institutes of Health $430,000 R21 grant will allow Drs. Elankumaran Subbiah; assistant professor in the Department of Biomedical Sciences and Pathobiology at Virginia Tech; and Siba Samal, associate dean of the colleges University of Maryland campus, to build upon existing work that is focused on the use of reverse genetics to alter the Newcastle Disease virus to treat prostate cancer.

Reverse genetics is the process of generating a recombinant virus from cloned complimentary DNA or cDNA copy, explains Subbiah. Through the reverse genetics system, recombinant viruses can be designed to have specific properties that make them attractive as biotechnological tools, live vaccines, and cancer therapies. The change is achieved through the introduction of the desired changes in the cDNA, which are then transferred faithfully to the recombinant virus.

This differs from the previous work in that the recombinant [Newcastle Disease virus] will be targeted against different types of proteases, said Subbiah. Different types of cancer cells secrete different types of proteases. We are tailoring the virus to match the type of protease secreted by the cancer cells.

Normal, healthy cells have an interferon antiviral system that activates upon infection with the virus, thereby preventing replication of the virus, explains Subbiah. Cancer cells, however, have defective interferon antiviral systems, he said. [Newcastle] utilizes these defects to replicate specifically in the diseased cells. The replication of the virus generates apoptosisalso known as programmed cell death or cell suicidein the diseased cell.


'/>"/>
Contact: Christy Jackson
cljacks@vt.edu
540-231-7239
Virginia Tech
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Thermogenesis Announces New Initiative to Address Veterinary Regenerative Medicine
2. Veterinary Pet Insurance Data Reveals Pet Dental Health a Low Priority for Many Pet Owners
3. New Company Enters Companion Animal Veterinary Medicine Channel
4. Echo Healthcare Extends Stockholder Vote on Proposed Merger With XLNT Veterinary Care to January 4, 2008
5. Echo Healthcare Extends Stockholder Vote on Proposed Merger With XLNT Veterinary Care to December 28, 2007
6. AVMA Lauds Senators for Approving 2007 Farm Bill Legislation that Includes the Veterinary Workforce Grant Program
7. Veterinary Dentistry Opens Wide
8. Echo Healthcare Reschedules Stockholder Vote on Proposed Merger With XLNT Veterinary Care to December 21, 2007
9. BCP Veterinary Pharmacy Helps Cure Diabetic Cats with BCP PZI(R), the Closest Match to Feline Insulin Available
10. California Veterinary Medical Association Reacts to Supreme Court Decision
11. Henricksen Awarded 2007 Distinguished Veterinary Staff Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... locations will each receive $100,000 in funding to launch ... follow-up care for patients served by community health centers. ... Cancer Roundtable and is part of the group,s effort ... 50 and over receiving regular screening for colorectal cancer ... competitive process are: Port Royal, South Carolina; New Haven, ...
(Date:8/27/2014)... 27, 2014 Driven by the expanded ... expected to grow steadily during the next few years, ... 1.381 billion meters by end-2017. Tightness is an essential ... one of the most-used parts in an automobile. As ... at 995 million meters, up just under 15% y-o-y. ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Georgia ... has received a two-year, $600,000 grant from the ... Resources and Services Administration to support implementation of ... services for children and youth with autism spectrum ... worked with an Autism Advisory Council composed of ...
(Date:8/27/2014)... last things a parent wants to deal with, but ... a week old. , Skin that turns yellow can ... and isn,t adequately eliminating the chemical bilirubin. But that ... left untreated can harm a baby. , University of ... that checks for jaundice in newborns and can deliver ...
(Date:8/27/2014)... 2014) -- Extremely low levels of the compound in ... halt the progression of Alzheimer,s disease, a recent study ... , Findings from the experiments, using a cellular model ... Journal of Alzheimer,s Disease . , Researchers from ... low doses of THC reduce the production of amyloid ...
Breaking Medicine News(10 mins):Health News:Pilot program aims to improve cancer screening, specialty care in community health centers 2Health News:Pilot program aims to improve cancer screening, specialty care in community health centers 3Health News:Automobile Weatherstrip Sector in China Analysed in New SinoMarketInsight Research Study Published at MarketPublishers.com 2Health News:Automobile Weatherstrip Sector in China Analysed in New SinoMarketInsight Research Study Published at MarketPublishers.com 3Health News:Center for Leadership in Disability Awarded $600,000 Grant to Improve Services for Georgia’s Children and Youth with Autism 2Health News:New smartphone app can detect newborn jaundice in minutes 2Health News:New smartphone app can detect newborn jaundice in minutes 3Health News:Marijuana compound may offer treatment for Alzheimer's disease 2
... managed by a specialty pharmacy program were more compliant ... hospitalized for their disease than those who were not ... study completed by HealthCore, Inc. , HealthCore researcher Jingbo ... of Pharmacoeconomic and Outcomes Research 14th Annual International Meeting ...
... against Chronic Migraines from Post-Traumatic Stress DisorderNEW YORK, May ... is making its new migraine treatment available free to ... According to published reports, alarming numbers of service men ... are suffering from migraines related to post-traumatic stress disorder ...
... WASHINGTON, May 20 The Council for American ... appointment and confirmation of Margaret Hamburg, M.D., to ... (Logo: http://www.newscom.com/cgi-bin/prnh/20090325/DC89081LOGO )"Commissioner Hamburg takes ... States faces unprecedented challenges in public health, and ...
... an economic environment in which all Americans are trying ... were prevented from filling critical prescriptions due to healthcare ... a solution. Medtipster ( www.medtipster.com ) has ... search engine and generic prescription drug price comparator. Now ...
... care for a loved can be a very complicated issue ... begin, let alone the right questions to ask when they ... consider it.The Heinz Family Philanthropies is adding a new series ... " 10 QUESTIONS TO ANSWER... "About Long-term Care. This ...
... the 80th anniversary of The Children,s Center of Wayne ... a Power of Possibilities Breakfast is being held on ... http://www.newscom.com/cgi-bin/prnh/20090423/CCWCLOGO ) Embarking on its ... of founder Senator James Couzens. His intention was ...
Cached Medicine News:Health News:MS patients more compliant with medications when managed by specialty pharmacy 2Health News:Clinical Topicals Makes Breakthrough Migraine Treatment Available Free to Soldiers 2Health News:Council for American Medical Innovation Applauds the Confirmation of Margaret Hamburg, M.D., to Lead U.S. Food and Drug Administration 2Health News:Medtipster, a Search Engine With a National Database of Generic Drugs on Discount Programs That Allows Visitors to Search by Zip Code, by Lowest Price, is Now Out of Beta 2Health News:Heinz Family Philanthropies (www.heinzfamily.org) Release Questions Families Should Ask About Long-Term Care - 10 Questions to Answer...(www.tenquestionstoanswer.org) 2Health News:Heinz Family Philanthropies (www.heinzfamily.org) Release Questions Families Should Ask About Long-Term Care - 10 Questions to Answer...(www.tenquestionstoanswer.org) 3Health News:80th Anniversary Power of Possibilities Breakfast Honors the Children's Center of Wayne County 2
(Date:8/27/2014)... , Aug. 27, 2014   Los Angeles orthodontics ... AcceleDent® Aura to patients who want to make their ... available at the OrthoSpaceship, all patients have a powerful ... This system can be used by most patients with ... of progress by using the AcceleDent® Aura system for ...
(Date:8/27/2014)... By now, if you haven,t heard about the ... planet. The awareness campaign has brought this devastating disease to ... over $88.5 Million (and counting) for ALS. Every day, more ... starting to as well. One such company, Acorn ... who actually works with ALS sufferers and helps to provide ...
(Date:8/27/2014)... York , August 27, 2014 ... United States  Laparoscopes Market Outlook to 2020. ... provides key market data on the United States ... of US dollars, volume (in units) and average prices ... Tip Video Laparoscopes and Flexible Tip Video Laparoscopes), Robotic ...
Breaking Medicine Technology:Los Angeles Orthodontist, Dr. Isaac Hakim, is Now Offering AcceleDent Aura 2Acorn Stairlifts Gives a Lift to the ALS Ice Bucket Challenge 2United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 2United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 3United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 4United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 5
... Del., Dec. 22, 2010 AstraZeneca ... notified Abbott that it will discontinue the development of CERTRIAD™ ... the treatment of mixed dyslipidemia. This means the co-development and ...   A Complete Response Letter (CRL) for the ...
... Dec. 22, 2010 The U.S. Food and Drug Administration ... anal cancer and associated precancerous lesions due to human ... people ages 9 through 26 years. (Logo: ... approved for the same age population for the prevention ...
Cached Medicine Technology:FDA: Gardasil Approved to Prevent Anal Cancer 2FDA: Gardasil Approved to Prevent Anal Cancer 3
... assembly. Superb Bi-Polar range of ... Superior pull-out and lever-out strength. ... 44, 48, 52, 56, 60 ... component for all shells. Increased ...
... index. A/P and lateral fins with holes ... medial hole, humeral / glenoid diametral curvature ... textured proximal surface to provide enhanced proximal ... cement, six stem sizes, fifteen head sizes ...
...
...
Medicine Products: