Navigation Links
Veterinary researchers discover first US strains of hepatitis E virus from rabbits
Date:10/25/2011

Researchers in the Virginia-Maryland Regional College of Veterinary Medicine at Virginia Tech have identified the first strains of hepatitis E virus from farmed rabbits in the United States. It is unknown whether the virus can spread from rabbits to humans.

Caitlin Cossaboom of Salisbury, Md., a second-year student in the combined Doctor of Veterinary Medicine and Ph.D. program in the Department of Biomedical Sciences and Pathobiology, is the first author of a publication entitled "Hepatitis E Virus in Rabbits, Virginia, USA" in the November issue of Emerging Infectious Diseases, published by the U.S. Centers for Disease Control and Prevention.

"Although researchers found hepatitis E virus in rabbits in China in 2009, this is the first time the virus has been identified in rabbits in the United States or anywhere outside of China," Cossaboom said.

Dr. X.J. Meng, professor of biomedical sciences and pathobiology in the veterinary college, Cossaboom's graduate advisor, and senior author of the study, identified the first animal strains of hepatitis E virus swine hepatitis E virus from pigs in 1997. Following the landmark study on swine hepatitis E virus by Meng and his colleagues at the National Institutes of Health's National Institute of Allergy and Infectious Diseases, researchers began to consider hepatitis E virus a zoonotic virus.

"Since 1997, researchers have found hepatitis E virus in pigs essentially in every swine-producing country and shown that the virus from pigs can infect humans," said Meng, who added that his lab also identified avian hepatitis E virus from chickens in the United States and that other researchers later discovered strains of the virus in other animal species, including rats, mongoose, deer, and wild boars.

Hepatitis E is an acute hepatic disease caused by infection with an RNA virus that has a fecal-oral transmission route. The disease is mainly prevalent in developing countries, though sporadic cases have been reported in industrialized countries such as the United States. The mortality rate associated with hepatitis E virus infection in humans is generally less than 1 percent, but it can reach up to 28 percent in infected pregnant women.

The virus has at least four distinct genotypes. Genotypes 1 and 2 infect only humans and typically occur in developing countries with poor sanitation conditions. Meanwhile, genotypes 3 and 4 are zoonotic, can spread from animals to humans, and are found in both industrialized and developing countries.

"It is worth noting that the strains of the virus found in rabbits in the U.S. and China closely relate to genotype 3, a genotype that has been shown to transfer from animals to humans," Meng said. "The question is, 'Do the strains of hepatitis E virus in rabbits infect humans?' We don't know, but the possibility is there and more research is needed to address this potential concern."

Cossaboom and her colleagues collected fecal and serum samples from 85 rabbits from two farms in Virginia one in Southwest Virginia and one in Eastern Virginia and found that approximately 50 percent of the rabbits were exposed to the hepatitis E virus. Researchers were able to genetically identify four isolates of the virus from the two rabbit farms.

"For future research, we are particularly interested in the potential zoonotic infection of humans and food safety concerns," Cossaboom said.

She added that pigs can serve as "animal reservoirs" for genotypes 3 and 4 hepatitis E virus. In other words, the pigs can carry and shed the virus, and occasionally the virus may transmit to humans. "However, it is unknown if the virus from rabbits can infect across species or serve as a reservoir," Cossaboom said.

There are five known types of viral hepatitis: Hepatitis A transmits from person to person from ingesting contaminated food and water. Hepatitis B and C spread by blood-to-blood contact; the hepatitis C virus can also cause chronic infection and, in some cases, liver cancer. Hepatitis D occurs in individuals who already have hepatitis B. Although all of these viruses, including hepatitis E virus, target the liver, none of them are genetically related.


'/>"/>
Contact: Michael Sutphin
msutphin@vt.edu
540-231-6716
Virginia Tech
Source:Eurekalert  

Related medicine news :

1. Summit VetPharm Enters Agreement With MWI Veterinary Supply to Distribute Vectra(R) Products
2. New Online Veterinary Video CPD Provides Accessible Learning for Veterinary Surgeons and Nurses
3. Scottsdale Veterinary Pharmacy Celebrates Success in Business By Dodging Veterinary Drug Shortages
4. Medical Gas Systems Available from DRE Veterinary
5. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
6. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
7. Researchers discover new way to kill pediatric brain tumors
8. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
9. Researchers create drug to keep tumor growth switched off
10. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
11. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Veterinary researchers discover first US strains of hepatitis E virus from rabbits
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic ... Frederick area economy by obtaining investment capital for emerging technology companies. SCP ... that have already resulted in more than a million dollars of capital investment ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the ... (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, ... Global Forecast to 2021" report to their offering. ... pharmaceutical excipients market is projected to reach USD 8.1 ... the forecast period 2016 to 2021. ...
(Date:6/23/2016)... June 23, 2016 Capricor ... ), a biotechnology company focused on the discovery, ... that patient enrollment in its ongoing randomized HOPE-Duchenne ... exceeded 50% of its 24-patient target. Capricor expects ... third quarter of 2016, and to report top ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at www.diabetesscholars.org by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
Breaking Medicine Technology: