Navigation Links
Vet medicine researcher examines link between cancer, Down syndrome
Date:2/4/2008

COLLEGE STATION, Feb. 4, 2008 Theres new hope for breast cancer research, and its coming from a very unlikely place. Researchers at the Texas A&M University College of Veterinary Medicine & Biomedical Sciences recently published articles in the journals Molecular and Cellular Biology and Carcinogenesis indicating that a protein long suspected to play a role in Down Syndrome may also contribute to treating this devastating disease.

It has long been known that Down Syndrome is caused when an individual has an extra copy of the 21st chromosome, giving them a total of three instead of the normal chromosome pair. With improved medical care, people with Down Syndrome are now living longer, healthier lives. With this advance came the observation that individuals with Down Syndrome have a significant decrease in risk for several types of tumors. Most striking is the observation that women with Down Syndrome are 10-25 times less likely to develop breast cancer.

This effect is thought to be due to the presence of one or more tumor suppressor genes on chromosome 21. However, the identity of such genes has not been known, until now.

Years of research into the genetics of Down Syndrome have helped us to discover a very important gene on chromosome 21, said Dr. Weston Porter, associate professor in the Veterinary Integrative Biosciences Department. This gene, called Single-minded 2 or SIM2 is thought to play an important role in Down Syndrome by regulating neuron growth in the developing brain. Based on its developmental role, we hypothesized that SIM2 may also be involved in breast cancer, which is essentially a disease of uncontrolled growth.

For the last five years, Porter and his colleagues, Richard Metz, Brian Laffin and Elizabeth Wellberg, have been using human breast cells and mouse models as part of a research grant from the National Institutes of Health to validate this hypothesis, and what they have found they consider very promising. SIM2 is lost or suppressed in a majority of human breast tumors, and deletion of the SIM2 gene triggers rapid tumor growth in mice.

However, the process by which SIM2 suppresses breast cancer is complex and not fully understood. This same protein which may hold so much promise for breast cancer treatment is also thought to contribute to the negative effects of Down Syndrome.

As we move forward, said Porter, it will be important for us to understand the circuit of SIM2 and how it is turned on and off. In light of the available data on breast cancer incidence in the Down Syndrome population and our experimental data, knowing how to turn SIM2 expression on and off and identification of down-stream targets should have great therapeutic value.

While still in the early stages, this research represents a promising weapon in the fight against breast cancer as it sheds light on a previously unknown target for which to shoot.

What we are seeing now is a paradigm shift in breast cancer research said Porter. For years we have gone after the wrong kinds of cells. It was all about getting rid of the tumor itself. This has led to a dandelion effect where, we didnt get to the root and the cancers kept coming back and spreading. Now were looking at ways to get to the root of breast cancer, and not simply shrinking the tumor to come back another day.

While it may be years before their research results in a definitive treatment or cure, Weston says it is impacting our approach towards understanding breast cancer today.


'/>"/>

Contact: Keith Randall
keith-randall@tamu.edu
979-845-4644
Texas A&M University
Source:Eurekalert

Related medicine news :

1. Medical Simulation Corporation and the American Board of Internal Medicine Introduce New Simulation for Physician Assessment and Evaluation
2. Pelosi: President Bushs Proposed Medicare and Medicaid Cuts Are Exactly the Wrong Medicine
3. American College of Preventive Medicine calls on ABC to cancel Eli Stone episode
4. American Journal of Disaster Medicine Accepted for Inclusion into The National Library of Medicines MEDLINE Database and may now be Accessed Through the PUBMED Website or the MEDLARS System
5. Temple University Hospital, Temple University School of Medicine and Crozer-Keystone Health System Collaborate to Provide Comprehensive Kidney Care
6. CDC Report Highlights the Need for Safe Use and Safekeeping of Medicines
7. Reproductive Medicine & Fertility Center is First in Southwest to Offer Pioneering Test of a Womens Biological Clock
8. Pain medicine meeting unites top researchers and clinicians
9. Boston Scientific Comments on New England Journal of Medicine Article
10. Makers of OTC Cough Medicines Reaffirm Efficacy of Products
11. New Company Enters Companion Animal Veterinary Medicine Channel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2017)... ... 27, 2017 , ... Thinksport, the leaders in safe, non-toxic ... sunscreen they’ve used the same scientific approach to solving smelly, sweaty athletes, by ... aisles that contain harmful chemicals that should be put nowhere near your skin ...
(Date:4/27/2017)... ... ... Goodcents Deli Fresh Subs announced a franchise expansion agreement today including three ... The first new location will open at the corner of 27th and Randolph in ... Drive this fall. And the third location is in the process of being identified. ...
(Date:4/26/2017)... ... April 26, 2017 , ... Jump Technologies, Inc., ... announced it has completed a round of funding to accelerate its growth strategies. ... Black Granite Capital is a growth equity firm focused on investments in healthcare ...
(Date:4/26/2017)... ... April 26, 2017 , ... CareSet ... adoption of e-prescribing as measured in Part D Medicare data. The dataset, called ... pharmacies, either using e-prescribing, faxes or paper. The PaPR (pronounced "paper") data ...
(Date:4/26/2017)... ... 26, 2017 , ... Infertility may be a result of ... helped many women become pregnant upon treating their diagnosis. , To ... evaluations. We can provide the necessary information to diagnose and treat your ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017 ... an immune response in pets such as canine, ... are of various types such as Attenuated Live ... Vaccines, DNA Vaccines and Recombinant Vaccines. Attenuated live ... virus or bacteria, which have been weakend under ...
(Date:4/18/2017)... DUBLIN, Ohio , April 18, 2017  Cardinal ... its Non-GAAP 1 fiscal 2017 earnings per share ... 2018 and 2019.  This is in conjunction with this ... Care, Deep Vein Thrombosis and Nutritional Insufficiency businesses. ... EPS from continuing operations will be at the bottom ...
(Date:4/18/2017)... DIEGO , April 18, 2017  Astute Medical, ... a case series to be presented at the 2017 ... which begins today and continues through April 22. Physicians ... IGFBP-7 , used to assess risk for acute kidney ... decompensated heart failure (ADHF). Elevated levels ...
Breaking Medicine Technology: