Navigation Links
Very Obese People May Be Missing Genes
Date:2/3/2010

Study adds to theories linking obesity and DNA

WEDNESDAY, Feb. 3 (HealthDay News) -- Adding more evidence to theories linking DNA to weight, European scientists report that a genetic variation seems to virtually guarantee that a person will become obese.

The genetic variation in question robs people of about 30 genes and appears to be found in seven of every 1,000 severely obese people, the researchers report. The same variation also may be linked to mental retardation and learning disabilities.

"Obesity is definitively a genetic trait, and it is very likely that additional small chromosomal abnormalities exist that may dramatically increase the risk of obesity and may also be linked to brain developmental problems," said Dr. Philippe Froguel, co-author of a study published in the Feb. 4 issue of the journal Nature and head of genomic medicine at Imperial College London.

In the new study, researchers examined the genes of teens and adults who had learning difficulties and developmental delays. Thirty-one people were missing the genes in question, and all were obese.

The researchers then looked at the genomes of 16,053 people who were either of normal weight or obese. Nineteen people had the same genetic deletion, and all were severely obese.

"We feel that this is a major advance -- the first paper to convincingly demonstrate that a relatively rare genetic variant can also be an important cause of common obesity," said study co-author Alexandra Blakemore, a senior lecturer at Imperial College London.

"Although the percentage of severely obese people with this (variation) is just under one person, that adds up to an awful lot of people in total," Blakemore said. "The effect on carriers is very strong."

But what are the missing genes doing to the body to make people become obese? That remains to be determined.

"The mechanism by which this genetic defect unveils itself may give us insight into how other conditions lead to obesity. There may be an enzyme or a protein that is involved in the development of obesity," said Dr. Stuart Weiss, an assistant clinical professor at NYU Langone Medical Center, who is familiar with the study findings.

Finding the cause "will allow us to investigate medications and therapies" that could turn something in the body on or off, he said.

Not all obese people can get skinnier by eating less and exercising more, Weiss said. "The bottom line is that they may be able to eat less, but their bodies may be so efficient that they can extract calories from food much more effectively and may not be burning energy as efficiently as others," he said.

This fact leads to unhappy news for some obese people, he said. "If you're eating just one pea and you're gaining weight, you'll have to cut the pea in half."

Still, the future could bring genetic tests for patients that could allow doctors to tailor treatments to their particular bodies, he added.

More information

The U.S. National Institutes of Health has more on obesity.



SOURCES: Philippe Froguel, M.D., Ph.D., professor and head, genomic medicine, and Alexandra Blakemore, Ph.D., senior lecturer, Imperial College London; Stuart Weiss, M.D., clinical assistant professor, medicine, NYU Langone Medical Center, New York City; Feb. 4, 2010, Nature


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Eating junk food whilst pregnant and breastfeeding may lead to obese offspring
2. Despite overeating, morbidly obese mice gain protection against diabetes
3. Obese Children Miss More School Days
4. Stop eating for two: obese moms-to-be should gain less weight than currently recommended
5. Obese children show early signs of heart disease
6. Food restriction increases dopamine receptor levels in obese rats
7. Study links hypertension in obese children to television viewing
8. Why Obese Men Post Lower PSA Levels
9. Study suggests adjusting PSA scores for obese men or cancers may be missed
10. Childhood sleep-disordered breathing disproportionately affects obese and African-Americans
11. Overweight Kids Often Become Obese, Unhealthy Adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2017)... ... June 27, 2017 , ... Drs. Gregory ... hygiene symposium in Mystic, CT. Covering the process and maintenance strategies of gum ... these popular periodontal procedures. Drs. Toback and Urbanski practice as experienced periodontists ...
(Date:6/27/2017)... , ... June 27, 2017 , ... ... . Orthodontics is a dental specialty that focuses on treating alignment and occlusion ... improved aesthetics and function. , North Hollywood dentist , Dr. Garemani, ...
(Date:6/26/2017)... ... ... Center is now offering various types of dental implants to restore lost teeth. Dental implants ... such as crowns, bridges, or dentures. An implant is placed directly into the jawbone where ... tooth. , Several types of dental implants are available, including: , ...
(Date:6/26/2017)... Ruidoso, New Mexico (PRWEB) , ... June 26, ... ... sexual dysfunction, anorgasmia, and urinary leakage is revolutionizing the way women look and ... Mexico is tackling the problem of female sexual dysfunction and urinary leakage head ...
(Date:6/26/2017)... (PRWEB) , ... June 26, 2017 , ... New patients ... from Dr. Angela Cotey, with or without a referral. Dr. Cotey is a trusted ... of this preferred tooth replacement option. , Patients with missing teeth in Fitchburg, WI, ...
Breaking Medicine News(10 mins):
(Date:6/11/2017)... June 10, 2017  Eli Lilly and Company (NYSE: ... Phase 3 studies of galcanezumab, an investigational treatment for ... data on several key secondary endpoints for galcanezumab compared ... these studies (EVOLVE-1, EVOLVE-2 and REGAIN) will be presented ... meeting in Boston . ...
(Date:6/8/2017)... 2017  Less than a month ago, amateur hackers ... companies, including hospital networks, in over 150 countries. ... the largest online extortion attempts ever recorded. With the ... is imperative that providers understand where the risks lie, ... — and many other very real cyber threats.  ...
(Date:6/7/2017)... , June 7, 2017  Novavax, Inc., (Nasdaq: ... of two Phase 2 trials of its RSV F protein ... child bearing age have been published in the journal ... have been shared in prior scientific conferences). The Company previously ... April 2014. Novavax is developing the RSV F Vaccine with ...
Breaking Medicine Technology: