Navigation Links
Vertebroplasty for patients with osteoporosis provides effective pain relief
Date:3/15/2010

TAMPA, Fla. (March 15, 2010)Patient selection is key for vertebroplastya minimally invasive treatment performed by interventional radiologists in individuals with painful osteoporotic vertebral compression fractures that fail to respond to conventional medical therapyto be effective and successful, according to a study of more than 1,500 persons who were followed over seven years. Additionally, collaboration between an interventional radiologist and other medical experts in treating a patient is imperative, say researchers at the Society of Interventional Radiology's 35th Annual Scientific Meeting in Tampa, Fla.

"Vertebroplasty puts lives and vertebrae back together," said Giovanni C. Anselmetti, M.D., interventional radiologist at the Institute for Cancer Research and Treatment in Turin, Italy. Before treatment, many osteoporotic patients are in constant pain and cannot manage everyday activities. Vertebroplasty, a minimally invasive treatment performed by interventional radiologists under imaging guidance, stabilizes collapsed vertebrae with the injection of medical-grade bone cement into the spine. The treatment provides pain relief and improves one's quality of lifeif given to appropriately selected candidates in whom conventional medical treatment has failed (such as analgesics or narcotic drugs that provide minimal or no pain release or doses that are intolerable), he further explained. "Our long-term follow-up confirmed this: pain relief and quality of life significantly improved with vertebroplasty," said Anselmetti.

Osteoporosis, the most common type of bone disease, is characterized by low bone mass and structural deterioration of the bone, resulting in an increased susceptibility to fractures. Osteoporosis affects 10 million Americans and is responsible for 700,000 vertebral fractures each year. Multiple vertebral fractures can result in chronic pain and disability, loss of independence, stooped posture and compression of the lungs and stomach.

"Vertebroplasty dramatically improves back pain within hours of the procedure, provides long-term pain relief and has a low complication rate, as demonstrated in multiple studies," said Anselmetti. Vertebroplasty provides pain relief from the complications of osteoporosis (vertebral fractures) but not the disease that caused it (osteoporosis), said Anselmetti. "For the best results, collaboration between physicians is mandatory. All osteoporotic patients need to be followed by an interventional radiologist, who determines which patients are appropriate candidates to receive vertebroplasty treatment, and an experienced medical expert (in this study, a rheumatologist) to ensure continued treatment for osteoporosis," he said.

Anselmetti illustrated a typical case: an 80-year-old Italian woman, who was diagnosed last year with two painful osteoporotic vertebral collapses, underwent medical treatment for osteoporosis (with the drug teriparatide) and was still in pain when she was prescribed an external brace. After there was evidence of two new fractures (verified by MR imaging), she received vertebroplasty, experiencing "complete pain regression, no need for the brace and a dramatic Lazarus-like ability to perform daily activities," he noted.

Researchers studied 2,251 osteoporotic patients (1,811 women; average age, 65) suffering from back-pain for vertebral collapses (MRI confirmed) who underwent a clinical interview; their medical treatment, pain grade, quality of life and extent of vertebral fracture were reviewed. Vertebroplasty was performed in 1,542 patients (1,302 women; average age, 73) when optimal medical treatment (such as biphosphonates, teriparatide, analgesics and back brace) did not help relieve pain or improve quality of life for patients over a three-month period. After vertebroplasty, patients continued to receive medical treatment with a rheumatologist. Because interventional radiologists use high-quality, image-guiding systems (such as digital flat-panel fluoroscopy with built-in rotational image acquisition), treatment time is decreased, making for a safer procedure, added Anselmetti.

In 1,494 patients (96.9 percent), the average pretreatment pain score on the 11-point visual analog scale was 8.21.8, and it dropped "significantly" to an average of 1.11.6 after vertebroplasty treatment, said Anselmetti. A patient's ability to manage everyday lifesuch as washing, dressing or standingwas measured by the commonly used Oswestry Disability Questionnaire, which was completed by patients before and after vertebroplasty. The ODQ scores changed from an average of 68.77.6 percent to 18.58.2 percent. Long-term follow-up (average, 31.2 months) in 1,017 patients (857 women; average age, 72) showed the VAS significantly dropping from 7.91.5 to 1.31.7. Of the 757 patients wearing a back brace before vertebroplasty, 683 could stop wearing one after treatment.

Anselmetti said that additional studies need to be performed, such as a large randomized trial comparing conventional medical treatment to medical treatment plus vertebroplasty. In Europe, this is difficult, as patients with chronic back pain for vertebral osteoporotic fractures prefer to be treated by vertebroplastyand not randomized into a medical treatment-only group. "Patients who are in so much pain ask if they can be considered for vertebroplasty treatment," said the co-author of "Percutaneous Vertebroplasty (PV) in the Osteoporotic Patients: Optimal Indications and Patient Selection to Improve Clinical Outcome: Personal Experience in 1,542 Patients Over Seven Years' Experience."


'/>"/>

Contact: Maryann Verrillo
mverrillo@sirweb.org
703-460-5572
Society of Interventional Radiology
Source:Eurekalert

Related medicine news :

1. Long-Term Data for 884 Patients Show Vertebroplasty for Osteoporotic Spinal Fractures Provides Dramatic Pain Relief, Greatly Decreases Disability
2. Cone-beam CT: Just as useful as MDCT before and after percutaneous vertebroplasty
3. Arizona Pain Specialists Contend Recent Vertebroplasty Studies are Misleading: Studies Actually Show it is Effective at Reducing Pain
4. Noted Vertebroplasty Expert Cites Concerns About Recently Published Study
5. Vertebroplasty: Integral to treating back pain in blood marrow cancer patients
6. Fluctuating eye pressure associated with visual field deterioration in glaucoma patients
7. Comparison of obstetric outcomes between on-call and patients own obstetricians
8. Vision restoration therapy shown to improve brain activity in brain injured patients
9. Diabetes appears to increase risk of death for patients with acute coronary syndromes
10. Ambulatory oxygen rarely a benefit in COPD patients without resting hypoxemia
11. Restricting Blood Flow May Help Heart Bypass Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... March 28, 2017 , ... The Executives, Staff & ... money to for the Toys for Tots Literacy Campaign at their Semi-Annual Graduation and ... of $70 billion, the U.S. ranks at number 14 internationally in literacy. Statistically, a ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... of SkyLex Advanced Surgical, Inc. is thrilled to offer the recently FDA-approved Obalon ... and this procedure adds to SkyLex Advanced Surgical’s already comprehensive list of ...
(Date:3/28/2017)... , ... March 28, 2017 , ... Silicon Valley Hair ... to announce a new blog post about women’s hair loss. Although hair transplant procedures ... loss as they age. Menopause or genetics can be two reasons a woman may ...
(Date:3/28/2017)... ... ... thrilling adventure that reveals the mystery of Kevin’s purpose. “A Prophets Bones” is the creation ... asked of him that he had neglected to do, but this was from God and ... some who would have felt themselves to be special and better than others due to ...
(Date:3/27/2017)... ... March 27, 2017 , ... ... custom smile makeovers without requiring a referral. Trimble Dental offers a ... treatment, cosmetic dentistry and dental implants. Whether patients have discolored, crooked or missing ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... 2017 /PRNewswire/ - INVICTUS MD STRATEGIES CORP. ("Invictus MD" ... MD is pleased to announce it has received conditional ... the TSX Venture Exchange.  Receiving the ... of significant achievements for Invictus-MD. Some of which include: ... AB Laboratories Inc. ("AB Labs"), a Licensed Producer under ...
(Date:3/27/2017)... The staggering cost of cancer treatment means ... to the latest treatment options against cancer. Even among ... have inadequate or no health insurance and are oftentimes ... to modern cancer treatment is almost non-existent for cancer ... The mission statements of pharmaceutical and biotech companies often ...
(Date:3/27/2017)... 2017 The global clinical ... billion by 2025, according to a new study by ... diseases is anticipated to be responsible for the high ... the scope for growth during the forecast period. In ... is highly susceptible to chronic diseases, is presumed to ...
Breaking Medicine Technology: