Navigation Links
Ventilation changes could double number of lungs available for transplant: study
Date:12/14/2010

TORONTO, Ont. 14, 2010Simple changes to how ventilators are used could almost double the number of lungs available for transplants, according to new international research involving a doctor at St. Michael's Hospital.

Many potential donor lungs deteriorate between the time a patient is declared brain dead and the time the lungs are evaluated to determine whether they are suitable for transplant. The study involving Dr. Arthur Slutsky, the hospital's vice president of research, said the deterioration could be in part because of the ventilatory strategy used while potential donors were observed just prior to being declared brain dead.

His team, lead by Dr. Marco Ranieri of the University of Turin in Italy, tested a "lung protective strategy" on patients in 12 hospitals in Spain and Italy that resulted in a significant increase in the number of viable donor lungs that were transplanted. Their results are published in the current issue of the Journal of the American Medical Association.

The strategy involved using smaller "tidal volumes," meaning less air was pumped into the lungs with each breath, to prevent injury to the lungs. It also used higher "positive-end expiratory pressure," the amount of pressure applied by the ventilator at the end of an exhalation, to prevent lungs from collapsing.

"A lot of patients who are waiting for lung transplants die before they get a transplant because there aren't enough organs," said Dr. Slutsky, the only Canadian on the research team. "By using this lung protective strategy, one can essentially double the number of lungs available for transplant."

The randomized study involved 118 patients. Of the 59 patients treated with conventional ventilation, 32 (54 per cent) met lung donor eligibility criteria. Of those on the lung protective strategy, 56 (95 per cent) met the criteria. Ultimately, double the number of lungs was transplanted in the group treated with the lung protective strategy.

According to the Canadian Institute for Health Information, 1,222 lung transplants were performed in Canada between 1997 and 2006, but 299 people died while waiting for a transplant. There were 252 people waiting to receive lung transplants in 2006, up from 119 in 1997.

"This is pretty simple and easy to implement," Dr. Slutsky said. "It's not like a fancy new drug or equipment. You just have to change the ventilator a little bit."

Dr. Slutsky said some doctors and hospitals may already be following a similar "lung protective strategy" but this is the first published randomized clinical trial showing it works, which could lead to standards that all hospitals would follow.

"If this is adopted widely, we think it will increase the number of lungs available for transplant, increase the quality of life for some people and probably save the lives of some people who are on the waiting list," he said.


'/>"/>

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital
Source:Eurekalert

Related medicine news :

1. Older survivors of mechanical ventilation can expect significant disability
2. Elderly Often Disabled After Mechanical Ventilation
3. Physical Changes in Brain Linked to Altered Spirituality
4. Northern California Cancer Center Changes Name to Cancer Prevention Institute of California
5. Medicare Advantage Members May Make Changes During Open Enrollment
6. CMS Watch Changes Name to The Real Story Group
7. Changes during menopause increases risk of heart disease and stroke
8. Childhood stress such as abuse or emotional neglect can result in structural brain changes
9. Dmatek Changes its Name to Attenti
10. Long Island Pediatric Group Announces Policy Changes That Will Help More New Yorkers
11. YourHCG.com Changes the Way People Lose Weight by Offering an Affordable HCG Diet Plan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... A health conscious snack ... The Dough Bar, has ignited an undeniable buzz in the protein product community ... not just any doughnut.  These doughnuts are packed with 11 grams of protein and ...
(Date:5/26/2016)... Boston, MA (PRWEB) , ... May 26, 2016 ... ... working to enhance surgical safety efforts for several years, and the efforts have ... significantly decreased. These efforts include new standards of care to enhance perioperative patient ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... seeking nominations to serve on its Accreditation and Standards Committees and support ... quality-benchmarking activities incorporate key process and outcome measures, with the ultimate mission ...
(Date:5/26/2016)... ... May 26, 2016 , ... Dalton Pharma Services, ... has successfully completed another Health Canada inspection and has received a compliant rating ... resulted from a Good Manufacturing Practices (GMP) inspection conducted at Dalton’s facility during ...
(Date:5/26/2016)... ... May 26, 2016 , ... HealthPostures, ergonomics designer and maker ... furniture that may support women during pregnancy. Potential benefits of using the Stance Angle ... and comfort and healthier levels of sitting and standing. , Need for the ergonomics ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... N.J. , May 24, 2016 ... oncology drug development company, today provided an update ... dose escalating clinical trial combining GEN-1, the Company,s ... the treatment of newly-diagnosed patients with advanced ovarian ... interval debulking surgery.  GEN-1 is an IL-12 DNA ...
(Date:5/24/2016)... May 24, 2016 Los ... terapia del mundo, introduce catéteres para la intervención ... OrbusNeich, una compañía global especializada en el suministro ... expandido su cartera incluyendo productos para tratar la ... Scoreflex™ PTA son los dispositivos de primera entrada ...
(Date:5/24/2016)... Dutch surgeons have launched a ground-breaking medical app to help doctors ... a global scale. Medical professionals from Europe , ... the US have already signed up for the app, which combines ... environment. Education  "Imagine a doctor for Medicines ... at Harvard to treat a bomb victim via live streaming - ...
Breaking Medicine Technology: