Navigation Links
'Velcro protein' found to play surprising role in cell migration
Date:3/13/2014

rounding gel, the researchers were surprised to find that most of the epithelial cells remained connected to each other, although their organization was disrupted. Some of the epithelial cells did penetrate the gel, but usually in single-file "columns" that remained connected to the tissue. A similar result was seen in live mice.

"For tumor cells to metastasize, they have to begin interacting with the proteins outside of the tumor and eventually strike out on their own," says Eliah Shamir, a graduate student in Ewald's lab and lead author on the study. "When we deleted E-cadherin, the epithelial cells began interacting more with proteins in the gel, but they didn't lose contact with the rest of the mammary tissue."

In a second set of experiments, the team turned on a gene called Twist1, which is thought to affect the activity of many genes needed to transform groups of stationary epithelial cells into independent, mobile cells. The result, they say, was dramatic. Within 24 hours of turning on Twist1, dozens of individual cells began to move past the epithelial boundary and into the gel beyond. Again, similar results were seen when the experiment was repeated in live mice.

Surprisingly, the researchers say that when they caused epithelial cells lacking E-cadherin to turn on Twist1, the cells were no longer able to escape into the gel as single cells. Instead, they created many "columns" of cells, which didn't detach from the mammary tissue. These results suggest that the single-celled detachment and migration induced by Twist1 actually requires the presence of E-cadherin the Velcro protein that helps bind the cells together. "This finding is quite counterintuitive," Ewald says, "and we are eager to understand the biology behind it."

Since Twist1 is known to affect the activity of many genes, the researchers have begun to narrow down which of those genes is responsible for the cellular spread they witnessed. With that information,
'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Warwick scientists uncover how checkpoint proteins bind chromosomes
2. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
3. Unusual protein helps regulate key cell communication pathway
4. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
5. RANK protein promotes the initiation, progression and metastasis of human breast cancer
6. Protein may represent a switch to turn off B cell lymphoma
7. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
8. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
9. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
10. New molecular structure offers first picture of a protein family vital to human health
11. Wayne State University researcher examines proteins role in diabetic retinopathy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Velcro protein' found to play surprising role in cell migration
(Date:7/6/2015)... (PRWEB) , ... July 06, 2015 , ... doTERRA, the ... to its executive management team. Most recently, Jowers held the position as Director of ... years. , After spending a decade building the institute, Jowers states that he was ...
(Date:7/6/2015)... ... July 06, 2015 , ... Seedstock today announced Pierre ... address at the 4th Annual Seedstock Sustainable Agriculture Conference – “Innovation and the Small ... , held at the University of California-San Diego, will explore solutions and methodologies that ...
(Date:7/6/2015)... Cutler Bay, Florida (PRWEB) , ... July 06, 2015 , ... ... 22nd facility on Monday, July 6. The newly constructed urgent care center will serve ... medical services. , In addition to being MD Now’s 22nd South Florida location, the ...
(Date:7/6/2015)... ... 2015 , ... The School of Public Health at Georgia ... effort to reduce rates of diabetes and cardiovascular disease in African-American neighborhoods in ... School of Medicine’s Prevention Research Center and the Satcher Health Leadership Institute as ...
(Date:7/6/2015)... ... July 06, 2015 , ... ... Randstad Technologies selected Aspect Software Unified IP contact center solution hosted by Promero. ... Aspect Unified IP as its future call center platform. , Promero will ...
Breaking Medicine News(10 mins):Health News:doTERRA Welcomes Kirk Jowers to Its Executive Team 2Health News:doTERRA Welcomes Kirk Jowers to Its Executive Team 3Health News:doTERRA Welcomes Kirk Jowers to Its Executive Team 4Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 2Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 3Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 4Health News:MD Now Urgent Care Opens its Fourth Miami-Dade County Facility in Cutler Bay 2Health News:MD Now Urgent Care Opens its Fourth Miami-Dade County Facility in Cutler Bay 3Health News:Georgia State, Morehouse Partner To Tackle Diabetes, Heart Disease In Atlanta’s Minority Communities 2Health News:Aspect Software Unified IP, Hosted by Promero, Selected by Randstad Technologies 2Health News:Aspect Software Unified IP, Hosted by Promero, Selected by Randstad Technologies 3
... Co., Inc.,today said that it has not yet received ... York City seeking Medicaid reimbursement costs. The,Company intends to ... the,Medicaid- related suits filed more than a year ago ... VIOXX(R) before and after receiving U.S. Food,and Drug Administration ...
... of Howard G.,Smith announces that a securities class action ... the common stock of LCA-Vision Inc.,("LCA-Vision" or the "Company") ... 30, 2007 (the "Class Period"). The class action lawsuit ... Southern District of Ohio. The Complaint alleges that ...
... Senior Living,Inc. (NYSE: BKD ) announced today that ... on its common stock of $0.50 per share for ... dividend is payable,on October 12, 2007 to holders of ... Brookdale Senior Living Inc. is a leading owner and ...
... ... to Discuss New Revenue Opportunities, Acquisition Integration and ... Q3 Guidance, NEW YORK, ... at the CL King,Best Ideas Conference. LodgeNet President & CEO Scott C. Petersen will,provide ...
... 17 Akers Biosciences,Inc. (LSE: AKR) which develops, ... testing products, is pleased to announce that it ... for the purchase of its,BreathScan alcohol safety units. ... beginning immediately. The Company has previously stated ...
... to take 10 Billion, Steps and Encourages Communities to ... More than 1,500 YMCAs nationwide,will reach out to ... during "America On the Move Week with the YMCA" ... On the Move,Foundation, aims to educate and motivate people ...
Cached Medicine News:Health News:Merck & Co., Inc. Response to Today's New York Medicaid Suit 2Health News:Merck & Co., Inc. Response to Today's New York Medicaid Suit 3Health News:LodgeNet to Present at CL King Best Ideas Conference 2Health News:LodgeNet to Present at CL King Best Ideas Conference 3Health News:LodgeNet to Present at CL King Best Ideas Conference 4Health News:LodgeNet to Present at CL King Best Ideas Conference 5Health News:Akers Biosciences, Inc. 'ABI' or the 'Company' Receipt of Further United States Military Contracts 2Health News:Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During 'America on the Move Week With the YMCA,' September 22-29, 2007 2Health News:Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During 'America on the Move Week With the YMCA,' September 22-29, 2007 3Health News:Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During 'America on the Move Week With the YMCA,' September 22-29, 2007 4Health News:Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During 'America on the Move Week With the YMCA,' September 22-29, 2007 5
(Date:7/6/2015)... 6, 2015 Mauna Kea ... multidisciplinary confocal laser endomicroscopy platform, announced today it ... Ministry of Health, Labor and Welfare (MHLW) ... the AQ-Flex 19 miniprobe.   Used ... miniprobe is comprised of a fiber-optic microscope that ...
(Date:7/6/2015)... 6, 2015   BioClinica®, Inc ., a ... announced that it has acquired a leading global ... Inc. (Medici).  The acquisition includes affiliates MediciGlobal ... also provides a lost-to-follow-up patient locate service ( ... with Medici, BioClinica will offer pharmaceutical ...
(Date:7/6/2015)... DUBLIN, Ohio , July 6, 2015 ... of The Harvard Drug Group (THDG). A distributor of generic ... and alternate care customers, THDG was owned by Court ... all-cash transaction using existing cash and new debt.  ... , The Harvard Drug Group had revenues of approximately ...
Breaking Medicine Technology:Mauna Kea Technologies Receives Regulatory Approval for the AQ-Flex 19 Miniprobe in Japan 2Mauna Kea Technologies Receives Regulatory Approval for the AQ-Flex 19 Miniprobe in Japan 3BioClinica Acquires MediciGroup 2BioClinica Acquires MediciGroup 3Cardinal Health Completes Acquisition Of The Harvard Drug Group For $1.115 Billion 2Cardinal Health Completes Acquisition Of The Harvard Drug Group For $1.115 Billion 3
... PRO-DEX, INC. (Nasdaq: PDEX ) will announce results for the Company,s fiscal ... on Thursday, April 29, 2010 after the market closes. , ... Following the release, Pro-Dex will conduct a ... ) to discuss operating performance for the quarter.  Mark Murphy, Chief Executive Officer ...
... PRINCETON, N.J. , April 23 Yesterday, ... first study comparing the once-daily human GLP-1 analog, Victoza® (liraglutide [rDNA] ... Victoza® produced significantly greater reductions in A1C, fasting plasma glucose (FPG), ... satisfaction. , , , ...
Cached Medicine Technology:Pro-Dex, Inc. Announces Fiscal 2010 Third Quarter Financial Results Conference Call and Webcast 2Pro-Dex, Inc. Announces Fiscal 2010 Third Quarter Financial Results Conference Call and Webcast 3The Lancet publishes new data demonstrating superior efficacy of Victoza(R) (liraglutide [rDNA] injection) compared to Januvia(R) (sitagliptin) in the treatment of type 2 diabetes 2The Lancet publishes new data demonstrating superior efficacy of Victoza(R) (liraglutide [rDNA] injection) compared to Januvia(R) (sitagliptin) in the treatment of type 2 diabetes 3The Lancet publishes new data demonstrating superior efficacy of Victoza(R) (liraglutide [rDNA] injection) compared to Januvia(R) (sitagliptin) in the treatment of type 2 diabetes 4The Lancet publishes new data demonstrating superior efficacy of Victoza(R) (liraglutide [rDNA] injection) compared to Januvia(R) (sitagliptin) in the treatment of type 2 diabetes 5The Lancet publishes new data demonstrating superior efficacy of Victoza(R) (liraglutide [rDNA] injection) compared to Januvia(R) (sitagliptin) in the treatment of type 2 diabetes 6
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: