Navigation Links
Vascular drug found to improve learning and memory in middle-aged rats
Date:2/1/2009

WASHINGTON A team of Arizona psychologists, geneticists and neuroscientists has reported that a safe and effective drug used to treat vascular problems in the brain has improved spatial learning and working memory in middle-aged rats. Although far from proving anything about human use of the drug, the finding supports the scientific quest for a substance that could treat progressive cognitive impairment, cushion the cognitive impact of normal aging, or even enhance learning and memory throughout the life span.

The finding appears in the February issue of Behavioral Neuroscience, which is published by the American Psychological Association. The drug in question, Fasudil, has been used for more than 10 years to treat vascular problems in the brain, often helping with recovery from stroke.

In this study, the researchers injected hydroxyfasudil, the active form of Fasudil, into middle-aged (17-18 months old) male rats daily starting four days before behavioral testing and continuing throughout testing. Injection made it easy to give the drug to rats, but people take it in pill form.

Rats were tested on the water radial-arm maze, which assessed how well they remembered which of the radiating arms had a reward, a sign of accurate spatial learning and working memory. Rats given a high dose (0.3750 mg per kg of weight) of hydroxyfasudil successfully remembered more items of information than those given a low dose (0.1875 mg per kg). Both dosed groups performed significantly better than control-group rats given saline solution. On this same test, the high-dose group showed the best learning (fewest total errors) and best working memory (measured two different ways).

For every test of learning, the scores of the low-dose group fell between the scores of the no-dose and high-dose groups, meaning that learning and memory boosts depended on the size of the dose.

The findings suggest that hydroxyfasudil may be involv
'/>"/>

Contact: Public Affairs
public.affairs@apa.org
202-336-5700
American Psychological Association
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Antioxidants show no clear benefit against cardiovascular events, death in high-risk women
2. Waist-to-hip ratio may better predict cardiovascular risk than body mass index
3. Pot bellies linked to early signs of cardiovascular disease
4. Air pollution linked to cardiovascular risk indices in healthy young adults
5. Environmental stress probed in cardiovascular disease, diabetes
6. Cardiovascular Technologies to be Highlighted at 5th Annual Cleveland Clinic Medical Innovation Summit, Oct. 1-3
7. American Heart Association Enhances eLearning for Emergency Cardiovascular Care (ECC)
8. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
9. GrantAdler Shipping Novel Implantable Vascular Access Port
10. Design Resource Extends Support for Orthopaedic and Cardiovascular Devices
11. LeMaitre Vascular to Start Italian Sales Force
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Padre Murphy's and Owner Tom Boyle in ... Player Health Alliance (PPHA). The PPHA's passion for others' ... including NFL greats, treated for obstructive sleep apnea (OSA) has ... the cause in the valley. The most recent plans for ...
(Date:1/22/2015)... is a famous wedding dress company offering many trendy designs. ... Facebook, Twitter, and Pinterest. The fans will have an opportunity ... every week. , Moreover, the company has extended its 2015 ... homepage for more information. , Angelweddingdress is a ...
(Date:1/22/2015)... New York (PRWEB) January 22, 2015 The ... ) in the U.S. District Court, Southern District of West ... Bard, Inc. in that proceeding’s first bellwether trial. In an ... for a new trial after finding that C.R. Bard had ...
(Date:1/22/2015)... New York (PRWEB) January 22, 2015 ... after Fresenius Medical Care recalled its GranuFlo and NaturaLyte ... multidistrict litigation underway in U.S. District Court, District of ... dated January 20th, the Court has remanded a case ...
(Date:1/22/2015)... released a new blog post presenting the basic features of ... an accidental death and dismemberment rider for a car insurance ... benefits if the insured dies in an accident. Accidental death ... insurance. , AD&D is not expensive and can be ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2
... of Alabama at Birmingham (UAB) Department of Pathology have ... predict which patients are more likely to develop aggressive ... shed light on the genetics that result in worse ... researchers said. In data presented April 19 at ...
... can affect language development in children, and EEG registrations ... with severe language impairment to identify more readily those ... the Sahlgrenska Academy at the University of Gothenburg. ... divided into groups. The first group comprised children with ...
... smokers in smoke-free settings, but doctors have concerns, ... tobacco giant R.J. Reynolds launched Camel Orbs, dissolvable nicotine ... for use by smokers who find themselves in smoke-free ... online edition of Pediatrics warn that the ...
... , BIRMINGHAM, Ala. Researchers at the University of ... a set of four biomarkers that will help predict ... cancer and which are not. The findings also shed ... cancer-treatment outcomes for African-Americans, compared with Caucasians, the researchers ...
... ... learn to use bioinformatics and genomics resources with the extensive tutorial suite catalog from OpenHelix. ... (PRWEB) April 19, 2010 ... a subscription to OpenHelix ( www.openhelix.com ) giving NIH scientists and staff access ...
... , ... how to age gracefully and maintain healthy skin? Here are 35 articles that cover the ... at any age, makeup tips for mature skin and the details on effective ingredients. ... (PRWEB) April 19, 2010 -- ...
Cached Medicine News:Health News:UAB researchers find 4 biomarkers important in colorectal cancer treatment prognosis 2Health News:Language dysfunction in children may be due to epileptic brain activity 2Health News:Kids Could Overdose From Nicotine-Laced 'Candy' 2Health News:UAB researchers find 4 biomarkers important in colerectal cancer treatment prognosis 2Health News:National Institutes of Health subscribes to OpenHelix training portal 2Health News:National Institutes of Health subscribes to OpenHelix training portal 3Health News:Anti-Aging Handbook: Top 35 Articles on Treating and Preventing Signs of Aging 2Health News:Anti-Aging Handbook: Top 35 Articles on Treating and Preventing Signs of Aging 3Health News:Anti-Aging Handbook: Top 35 Articles on Treating and Preventing Signs of Aging 4
(Date:1/23/2015)...  iMD Companies, Inc. (ICBU) has repositioned itself as a holding ... a foothold in the hydroponic, hemp and medical marijuana sectors. ... in the sector, and recently partnering with the Chippewa Tribe ... medical marijuana, iMD is committing to bring its vision to ...
(Date:1/23/2015)... MONMOUTH JUNCTION, N.J. , Jan. 23, 2015 ... immunotherapy company commercializing its CytoSorb® extracorporeal cytokine adsorber ... surgery patients, announced the receipt of $385,642, net ... approved participant of the Technology Business Tax Certificate ...
(Date:1/23/2015)... Tianyin Pharmaceutical Inc. (NYSE Amex: TPI ), ... sale of patented biopharmaceutical medicine, modernized traditional Chinese medicine ... announced the business and development progress at its Jiangchuan ... the September 2014 JCM application (No. 51268) for the ...
Breaking Medicine Technology:iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3TPI's JCM Updates on Import Registration for International Clients 2TPI's JCM Updates on Import Registration for International Clients 3TPI's JCM Updates on Import Registration for International Clients 4
... Modulator Administered in Dual Cord Blood Transplant for Hematologic MalignancyLA ... announced today that the first patient has been ... small molecule Stem Cell Modulator (SCM) designed to increase hematopoietic ... key pathways that guide cell fate. The study, which ...
... delivers Germ-Free cleaning, extending life, efficiency and healthiness of ... are almost neurotic about washing their hands and using ... at their computer and put their hands all over ... ground for these persistent little bugs, which are known ...
Cached Medicine Technology:Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support 2Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support 3Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support 4GreenBytes Wards Off Germs and Costly Computer Repairs 2GreenBytes Wards Off Germs and Costly Computer Repairs 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: