Navigation Links
Vascular drug found to improve learning and memory in middle-aged rats
Date:2/1/2009

WASHINGTON A team of Arizona psychologists, geneticists and neuroscientists has reported that a safe and effective drug used to treat vascular problems in the brain has improved spatial learning and working memory in middle-aged rats. Although far from proving anything about human use of the drug, the finding supports the scientific quest for a substance that could treat progressive cognitive impairment, cushion the cognitive impact of normal aging, or even enhance learning and memory throughout the life span.

The finding appears in the February issue of Behavioral Neuroscience, which is published by the American Psychological Association. The drug in question, Fasudil, has been used for more than 10 years to treat vascular problems in the brain, often helping with recovery from stroke.

In this study, the researchers injected hydroxyfasudil, the active form of Fasudil, into middle-aged (17-18 months old) male rats daily starting four days before behavioral testing and continuing throughout testing. Injection made it easy to give the drug to rats, but people take it in pill form.

Rats were tested on the water radial-arm maze, which assessed how well they remembered which of the radiating arms had a reward, a sign of accurate spatial learning and working memory. Rats given a high dose (0.3750 mg per kg of weight) of hydroxyfasudil successfully remembered more items of information than those given a low dose (0.1875 mg per kg). Both dosed groups performed significantly better than control-group rats given saline solution. On this same test, the high-dose group showed the best learning (fewest total errors) and best working memory (measured two different ways).

For every test of learning, the scores of the low-dose group fell between the scores of the no-dose and high-dose groups, meaning that learning and memory boosts depended on the size of the dose.

The findings suggest that hydroxyfasudil may be involv
'/>"/>

Contact: Public Affairs
public.affairs@apa.org
202-336-5700
American Psychological Association
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Antioxidants show no clear benefit against cardiovascular events, death in high-risk women
2. Waist-to-hip ratio may better predict cardiovascular risk than body mass index
3. Pot bellies linked to early signs of cardiovascular disease
4. Air pollution linked to cardiovascular risk indices in healthy young adults
5. Environmental stress probed in cardiovascular disease, diabetes
6. Cardiovascular Technologies to be Highlighted at 5th Annual Cleveland Clinic Medical Innovation Summit, Oct. 1-3
7. American Heart Association Enhances eLearning for Emergency Cardiovascular Care (ECC)
8. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
9. GrantAdler Shipping Novel Implantable Vascular Access Port
10. Design Resource Extends Support for Orthopaedic and Cardiovascular Devices
11. LeMaitre Vascular to Start Italian Sales Force
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... (PRWEB) October 20, 2014 ASCNYC ... organization that helps New Yorkers living with HIV/AIDS ... toward health, housing, recovery and self-sufficiency. Each year, ... the local community through their tireless efforts. , ... Marc Shapses , has been selected as this ...
(Date:10/20/2014)... Ga. (PRWEB) October 20, 2014 ... and relationship-marketing firm, announced today that William H. ... named the 2014 ISE® Luminary Leadership Award winner. ... the achievements of an outstanding leader and industry ... and contributions in advancing the information security industry. ...
(Date:10/20/2014)... Zereana Jess-Huff, a 34-year-old mother, corporate executive ... a platform to think outside the bra. She doesn’t try ... to raise awareness about women’s other lady parts. , "We ... say the color pink and everybody knows what you’re talking ... that it has not been won when it comes to ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 My Clients ... management software application. The new module enables easy ... receive full life-cycle quality care. , This application allows ... within their practice, attach a to-do item to a ... and even set up reoccurring reminders for follow-ups. ...
(Date:10/20/2014)... October 20, 2014 AttorneyOne.com, a recognized authority ... information from the FDA on Sit and Slim II ... not to purchase or use Sit and Slim II because ... II is promoted as weight loss product on various websites ... the market in 2010 for safety reasons, can significantly increase ...
Breaking Medicine News(10 mins):Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 2Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 2Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 3Health News:My Clients Plus Announces New Workflow Management Software 2Health News:FDA Advises Not to Use Sit and Slim II: AttorneyOne Monitors and Keeps Consumers Informed 2
... study finds , , WEDNESDAY, Aug. 29 (HealthDay News) -- ... natural menopause increases the risk of both dementia and ... giving hormone-replacement therapy at least until the age of ... Mayo Clinic researchers. , "It,s the first study that ...
... suggests , , WEDNESDAY, Aug. 29 (HealthDay News) -- Can spotting ... simple as seeing which arm she uses to carry her ... cradle their baby on their right side may be struggling ... some levels of stress during the first weeks and months ...
... rates better than education or incomes, according to a ... this week by the journal Social Science and Medicine. ... homes, UW researchers found, obesity rates in a given ... based on analyses of responses to a telephone survey ...
... In a report that is among the first to ... C viruses in Afghanistan, a researcher from the University ... concerns that increasing injection drug use and accompanying high-risk ... , Our findings suggest that interventions to ...
... chances of being overweight, obese by age 7 were ... News) -- When women develop diabetes during pregnancy and ... of childhood obesity, but new research suggests that treatment ... the doubling of the risk of obesity can be ...
... by continued abuse, study finds , TUESDAY, Aug. 28 ... of the liver have more brain function impairment than ... gene expression in the frontal cortex of the brains ... cirrhosis. , "We found that the levels of many ...
Cached Medicine News:Health News:Removing Ovaries Before Menopause Leads to Memory, Movement Troubles 2Health News:Removing Ovaries Before Menopause Leads to Memory, Movement Troubles 3Health News:Stressed-Out Moms Carry Babies on the Right 2Health News:ZIP codes and property values predict obesity rates 2Health News:High-risk behaviors could lead to HIV epidemic in Afghanistan 2Health News:High-risk behaviors could lead to HIV epidemic in Afghanistan 3Health News:Treating Diabetes During Pregnancy Could Lead to Thinner Kids 2Health News:Alcoholics With Cirrhosis Have More Brain Damage 2
(Date:10/20/2014)... Norgine B.V. today announced that ... bowel preparation, NER1006, presented at the 79 th ... (ACG), Philadelphia, PA , has met ... co-primary endpoint of cleansing success. The study demonstrated high ... in screening colonoscopy patients. [1] ...
(Date:10/19/2014)... 19, 2014 Große Pharmafirmen ... Das Problem dabei ist, dass große Pharmafirmen nicht ... zu teilen. Es war deshalb nicht ... uns umso mehr, dass es uns gelungen ist! ... Kühlketten aufzuschreiben - mit einem Vorbehalt - einige ...
(Date:10/17/2014)... OAKS, Calif. , Oct. 17, 2014  Amgen ... of R. Sanders Williams , M.D., president of ... Mahley Distinguished Professor.  "We are pleased ... Amgen Board," said Robert A. Bradway , chairman ... and distinguished experience in academic medicine and his direct ...
Breaking Medicine Technology:Positive Results from Phase II Data Show NER1006 Achieves High Quality Bowel Cleansing Efficacy 2Vergleichsbericht zu Pharma-Kühlketten und CRT 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 3
... Topcon combines the best 32-bit software package ... hardware offerings to bring you a fast ... high-resolution package takes advantage of the Compaq ... latest graphics capture technology and a formidable ...
... The new TM-1 is a ... that provides precise measurement of ... transmission for all types of ... to easily connect with a ...
Inquire...
... This power table has everything that ... instrumentation. The new AIT-15 offers 20 mm ... convenience outlets, and locking castors to secure ... work perfectly for most any application. Use ...
Medicine Products: