Navigation Links
Vascular drug found to improve learning and memory in middle-aged rats
Date:2/1/2009

WASHINGTON A team of Arizona psychologists, geneticists and neuroscientists has reported that a safe and effective drug used to treat vascular problems in the brain has improved spatial learning and working memory in middle-aged rats. Although far from proving anything about human use of the drug, the finding supports the scientific quest for a substance that could treat progressive cognitive impairment, cushion the cognitive impact of normal aging, or even enhance learning and memory throughout the life span.

The finding appears in the February issue of Behavioral Neuroscience, which is published by the American Psychological Association. The drug in question, Fasudil, has been used for more than 10 years to treat vascular problems in the brain, often helping with recovery from stroke.

In this study, the researchers injected hydroxyfasudil, the active form of Fasudil, into middle-aged (17-18 months old) male rats daily starting four days before behavioral testing and continuing throughout testing. Injection made it easy to give the drug to rats, but people take it in pill form.

Rats were tested on the water radial-arm maze, which assessed how well they remembered which of the radiating arms had a reward, a sign of accurate spatial learning and working memory. Rats given a high dose (0.3750 mg per kg of weight) of hydroxyfasudil successfully remembered more items of information than those given a low dose (0.1875 mg per kg). Both dosed groups performed significantly better than control-group rats given saline solution. On this same test, the high-dose group showed the best learning (fewest total errors) and best working memory (measured two different ways).

For every test of learning, the scores of the low-dose group fell between the scores of the no-dose and high-dose groups, meaning that learning and memory boosts depended on the size of the dose.

The findings suggest that hydroxyfasudil may be involved in two crucial cognitive processes, learning and working memory, both involving the hippocampus. The mechanism is unclear, but hydroxyfasudil's parent drug, Fasudil, is known to protect the brain by dilating blood vessels when blood flow is curtailed. In the body, Fasudil breaks down into the more potent hydroxyfasudil molecule, which the authors hypothesize may alter memory by affecting the function of a gene called KIBRA. The authors recently demonstrated that KIBRA may play a role in memory in healthy young and late-middle-aged humans.

The authors wrote that their findings may have clinical relevance: "The collected findings and the relative safety of Fasudil support [its] potential ... as a cognitive enhancer in humans [who] have age- or neurodegenerative-related memory dysfunction."

Thus, said lead author Matthew Huentelman, PhD, "We have identified a drug that seems to benefit both the cardiovascular system, which it was originally designed to do, and the central nervous system, a new indication. We are actively exploring options for a clinical trial in the areas of cognitive impairment and dementia using the well-tolerated pro-drug Fasudil."

Co-author Heather Bimonte-Nelson, PhD, added that, "Fasudil shows great promise as a cognitive enhancer during aging. The effects in our aging animal model were robust, showing enhancements in both learning and two measures of memory. The possibility that these findings may translate to benefits to human brain health and function is very exciting."

Hydroxyfasudil inhibits the activity of Rho-kinase enzymes, which have been shown to inhibit Rac, a vital protein that supports key cellular functions. The authors speculated that blocking Rho-kinase enables Rac, in turn, to activate more of an enzyme called protein kinase C-zeta, which may in turn affect the KIBRA protein.


'/>"/>

Contact: Public Affairs
public.affairs@apa.org
202-336-5700
American Psychological Association
Source:Eurekalert

Related medicine news :

1. Antioxidants show no clear benefit against cardiovascular events, death in high-risk women
2. Waist-to-hip ratio may better predict cardiovascular risk than body mass index
3. Pot bellies linked to early signs of cardiovascular disease
4. Air pollution linked to cardiovascular risk indices in healthy young adults
5. Environmental stress probed in cardiovascular disease, diabetes
6. Cardiovascular Technologies to be Highlighted at 5th Annual Cleveland Clinic Medical Innovation Summit, Oct. 1-3
7. American Heart Association Enhances eLearning for Emergency Cardiovascular Care (ECC)
8. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
9. GrantAdler Shipping Novel Implantable Vascular Access Port
10. Design Resource Extends Support for Orthopaedic and Cardiovascular Devices
11. LeMaitre Vascular to Start Italian Sales Force
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... plastic surgeon practicing in Newburgh, New York, has recently begun offering three new ... to offering the best cutting-edge procedures and reducing downtime, Dr. Rubinstein is excited ...
(Date:6/23/2017)... ... June 23, 2017 , ... Everybody has their own personal preference when ... read it, and some people don't like it at all. FindaTopDoc took a look ... , Erotic literature can give readers a taste of their deepest, darkest fantasies and ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... The Aesthetic ... facelift . Dr. Talei has come up with a proprietary technique that he calls ... lifts tissues that have dropped. For all ages, patients can expect to look refreshed, ...
(Date:6/23/2017)... ... June 23, 2017 , ... Georgia ... Sept. 18 to 20. , The two-day conference is focused on advancing scientific ... of improving patients’ lives and eliminating racial breast cancer-related disparities. The conference theme ...
(Date:6/23/2017)... ... June 23, 2017 , ... MD Now Urgent ... is MD Now’s 28th facility overall and marks the urgent care center's eighth location ... mile North of The Falls shopping mall. The new clinic offers a wide array ...
Breaking Medicine News(10 mins):
(Date:6/1/2017)... Pa. , June 1, 2017 Nutriceutical ... and Veterinarian Recommended Solutions (VRS), and KD Pharma Group ... in Nutriceutical Holdings by KD Pharma Group. KD Pharma ... with the option to acquire the entire company. ... in KD. They are committed to growing the NH ...
(Date:5/29/2017)... AVIV, Israel, May 29, 2017  Cellect Biotechnology Ltd. ... innovative technology which enables the functional selection of stem ... results for the first quarter ended March 31 st ... with our accomplishments in the first quarter of 2017," ... first quarter, we announced the treatment of the first ...
(Date:5/23/2017)... 2017  Leaf Healthcare, recognized for developing one ... pressure ulcer prevention, will unveil its comprehensive mobility ... Care Nurses, National Teaching Institute and Critical Care ... Leaf Patient Monitoring System is the first mobility ... The system seamlessly tracks patient movement throughout the ...
Breaking Medicine Technology: