Navigation Links
Variations in Gene DNA Boost Drinkers' Cancer Risk

Changes to 2 alcohol-metabolizing enzymes are responsible, study says

FRIDAY, Jan. 30 (HealthDay News) -- Variations in the DNA of certain genes can increase the risk of cancer in people who drink alcohol, according to researchers who reviewed studies on alcohol consumption, genetic polymorphisms and cancer.

Their analysis suggests that such variations, called gene polymorphisms, in two enzymes -- alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) -- involved in metabolizing alcohol significantly increase alcohol drinkers' risk of cancers of the head and neck and the esophagus.

The researchers looked at the effect of gene variations in other enzymes involved in alcohol and folate metabolism but found there wasn't enough data to fully assess the effect of those gene variants on cancer risk.

They said that currently available data does not allow for a quantitative evaluation by meta-analysis of the link between gene variations and cancer risk in people who drink alcohol.

"We have highlighted the need for large, multicenter studies and for approaches to the study of multiple polymorphisms," wrote Dr. Nathalie Druesne-Pecollo and colleagues at the French National Institute of Agronomical Research.

The review was published in the February issue of the The Lancet Oncology.

Previous research has shown a clear link between alcohol consumption and health risk, according to background information in the review. Recent figures show that drinking alcohol was a major contributing factor in the development of almost 400,000 cancers worldwide in 2002. In that same year, 323,900 cancer deaths (3.6 percent of all cancer deaths) were alcohol-related.

More information

The U.S. Centers for Disease Control and Prevention has more about alcohol and health.

-- Robert Preidt

SOURCE: The Lancet Oncology, news release, Jan. 30, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. St. Jude finds more than 100 gene variations linked with response to leukemia treatment
2. Interleukin Genetics to Present Data Highlighting Link Between Inflammatory Gene Variations and Less Effective Weightloss
3. Comparative Effectiveness Research Tools Address Variations in corporate spending
4. Gene variations alter risk of esophageal cancer
5. MYH9 gene variations help explain high rate of kidney disease in African-Americans
6. Gene Variations May Predict Antidepressant Response
7. Study shows gene variations may predict risk of breast cancer in women
8. Genetic variations raise lung cancer risk for smokers and ex-smokers
9. New report highlights variations in approaches to thoracic surgery in the United Kingdom and Ireland
10. Study Finds Variations in Doses of Radiation Therapy
11. More Gene Variations Found That Raise Prostate Cancer Risk
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... ... its strategic partnership with Connance, a healthcare industry leader providing predictive analytics ... proprietary technology combine to provide health systems, hospitals and ambulatory surgical centers ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Pixel Film ... Pro X. , "Film editors can give their videos a whole new perspective by ... Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, Inc., ... development and manufacturing of collagen and mineral based ... today that Bill Messer has joined ... to further leverage the growing portfolio of oral ... Bill joins the Collagen Matrix executive ...
(Date:6/24/2016)...   Bay Area Lyme Foundation , collaborating ... for Tick Borne Illness , Harvard Medical School ... Medicine, University of California, Berkeley, and the Veterans ... finalists of Lyme Innovation , the first ... scientists, clinicians, researchers, entrepreneurs, and investors from several ...
(Date:6/24/2016)... -- Research and Markets has announced ... Applications, Technologies, Forecasts" report to their offering. ... Smart Skin, Structural Health Monitoring, Composite Smart Structures, ... involves electronic and/or electrical components and circuits that ... such as vehicle bodies or conformally placed upon ...
Breaking Medicine Technology: