Navigation Links
Variations in Gene DNA Boost Drinkers' Cancer Risk
Date:1/30/2009

Changes to 2 alcohol-metabolizing enzymes are responsible, study says

FRIDAY, Jan. 30 (HealthDay News) -- Variations in the DNA of certain genes can increase the risk of cancer in people who drink alcohol, according to researchers who reviewed studies on alcohol consumption, genetic polymorphisms and cancer.

Their analysis suggests that such variations, called gene polymorphisms, in two enzymes -- alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) -- involved in metabolizing alcohol significantly increase alcohol drinkers' risk of cancers of the head and neck and the esophagus.

The researchers looked at the effect of gene variations in other enzymes involved in alcohol and folate metabolism but found there wasn't enough data to fully assess the effect of those gene variants on cancer risk.

They said that currently available data does not allow for a quantitative evaluation by meta-analysis of the link between gene variations and cancer risk in people who drink alcohol.

"We have highlighted the need for large, multicenter studies and for approaches to the study of multiple polymorphisms," wrote Dr. Nathalie Druesne-Pecollo and colleagues at the French National Institute of Agronomical Research.

The review was published in the February issue of the The Lancet Oncology.

Previous research has shown a clear link between alcohol consumption and health risk, according to background information in the review. Recent figures show that drinking alcohol was a major contributing factor in the development of almost 400,000 cancers worldwide in 2002. In that same year, 323,900 cancer deaths (3.6 percent of all cancer deaths) were alcohol-related.

More information

The U.S. Centers for Disease Control and Prevention has more about alcohol and health.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, Jan. 30, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. St. Jude finds more than 100 gene variations linked with response to leukemia treatment
2. Interleukin Genetics to Present Data Highlighting Link Between Inflammatory Gene Variations and Less Effective Weightloss
3. Comparative Effectiveness Research Tools Address Variations in corporate spending
4. Gene variations alter risk of esophageal cancer
5. MYH9 gene variations help explain high rate of kidney disease in African-Americans
6. Gene Variations May Predict Antidepressant Response
7. Study shows gene variations may predict risk of breast cancer in women
8. Genetic variations raise lung cancer risk for smokers and ex-smokers
9. New report highlights variations in approaches to thoracic surgery in the United Kingdom and Ireland
10. Study Finds Variations in Doses of Radiation Therapy
11. More Gene Variations Found That Raise Prostate Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... - Cincinnati, Ohio (PRWEB) , ... December 09, ... ... the production of miniature, folded, pharmaceutical inserts and outserts. As a means ... Device. This addition will enable Flottman to individually code professional inserts (PIs) ...
(Date:12/9/2016)... ... December 09, 2016 , ... An inventor from Cana, Va., wanted to fulfill ... of amusement park rides. , The patent-pending SAFETY STRAP FOR AMPUTEES improves accessibility. It ... could be set up in a matter of minutes, or even seconds. The SAFETY ...
(Date:12/9/2016)... , ... December 09, 2016 , ... "I had a ... inventor from Winchester, Va. "I thought that if the nebulizer had a more child-friendly ... than fearing them." , He developed the patent-pending NEBY to avoid the need to ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... Research Institute (WCRI) officially opened registration today for its 33rd Annual Issues ... Boston, MA . , The theme of the conference is “Persistent Challenges and ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... Management (MTM), adherence, and other pharmacist-delivered patient care services, has announced the promotions ... Eric Hoessel to vice president of sales. , Litsinger joined Mirixa in ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... , Dec. 9, 2016  RxWiki Inc., a digital ... digital marketing strategies of thousands of pharmacies through its ... Austin Inno,s "50 on Fire" Award in ... "We,re pleased to accept the award as one of ... Chief Executive Officer at RxWiki. "Our platform gives independent ...
(Date:12/8/2016)... , Dec. 8, 2016 IRIDEX Corporation (NASDAQ: ... newly issued shares of common stock, $0.01 par value (the ... underwritten public offering.  The final terms of the Offering will ... pricing, and there can be no assurance as to whether ... expects to use the net proceeds it will receive from ...
(Date:12/8/2016)... , Dec. 8, 2016 Global Interventional ... on the global interventional radiology market analyzes the ... report comprises an elaborate executive summary, including a ... segments and sub-segments. The research is a ... formed the bulk of our research efforts along ...
Breaking Medicine Technology: