Navigation Links
Variations in Gene DNA Boost Drinkers' Cancer Risk
Date:1/30/2009

Changes to 2 alcohol-metabolizing enzymes are responsible, study says

FRIDAY, Jan. 30 (HealthDay News) -- Variations in the DNA of certain genes can increase the risk of cancer in people who drink alcohol, according to researchers who reviewed studies on alcohol consumption, genetic polymorphisms and cancer.

Their analysis suggests that such variations, called gene polymorphisms, in two enzymes -- alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) -- involved in metabolizing alcohol significantly increase alcohol drinkers' risk of cancers of the head and neck and the esophagus.

The researchers looked at the effect of gene variations in other enzymes involved in alcohol and folate metabolism but found there wasn't enough data to fully assess the effect of those gene variants on cancer risk.

They said that currently available data does not allow for a quantitative evaluation by meta-analysis of the link between gene variations and cancer risk in people who drink alcohol.

"We have highlighted the need for large, multicenter studies and for approaches to the study of multiple polymorphisms," wrote Dr. Nathalie Druesne-Pecollo and colleagues at the French National Institute of Agronomical Research.

The review was published in the February issue of the The Lancet Oncology.

Previous research has shown a clear link between alcohol consumption and health risk, according to background information in the review. Recent figures show that drinking alcohol was a major contributing factor in the development of almost 400,000 cancers worldwide in 2002. In that same year, 323,900 cancer deaths (3.6 percent of all cancer deaths) were alcohol-related.

More information

The U.S. Centers for Disease Control and Prevention has more about alcohol and health.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, Jan. 30, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. St. Jude finds more than 100 gene variations linked with response to leukemia treatment
2. Interleukin Genetics to Present Data Highlighting Link Between Inflammatory Gene Variations and Less Effective Weightloss
3. Comparative Effectiveness Research Tools Address Variations in corporate spending
4. Gene variations alter risk of esophageal cancer
5. MYH9 gene variations help explain high rate of kidney disease in African-Americans
6. Gene Variations May Predict Antidepressant Response
7. Study shows gene variations may predict risk of breast cancer in women
8. Genetic variations raise lung cancer risk for smokers and ex-smokers
9. New report highlights variations in approaches to thoracic surgery in the United Kingdom and Ireland
10. Study Finds Variations in Doses of Radiation Therapy
11. More Gene Variations Found That Raise Prostate Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... ... July 21, 2017 , ... "As a doctor of lung medicine ... catheters available on the market," said an inventor from Center Valley, Pa. "My idea ... the patient." , He developed the patent-pending PLEURAL SAFE-t-STAT CATHETER KIT to offer an ...
(Date:7/21/2017)... ... July 21, 2017 , ... ... and financial planning services to communities in the greater Birmingham area, is joining ... resources to underprivileged young people in the region. , The Chris Hammond Youth ...
(Date:7/21/2017)... ... ... Bernard R. Bach, Jr., MD, orthopaedic surgeon at Rush University Medical Center ... Medicine (AOSSM) , received the 2017 Robert E. Leach Sports Medicine Leadership award on ... award is given annually to honor those who have made a significant contribution to ...
(Date:7/21/2017)... ST. LOUIS, MO (PRWEB) , ... July 21, 2017 , ... ... are born knowing how to tie their shoes,” says Suzanne Tucker, Founder of St. ... created the Time-In Toolkit, which launches on Kickstarter on Monday, July 21st. , ...
(Date:7/21/2017)... ... July 21, 2017 , ... ... concussion rates are on the rise, say researchers presenting their work at the ... Ontario, Canada. , “The combination of evaluating the patterns of change in concussion ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... CARLSBAD, Calif. , July 10, 2017  The ... in Boston, MA at the ... unequaled value and unparalleled access to global decision makers ... to draw 800+ life science leaders during two impactful ... Boston, and provides delegates with additional networking opportunities with ...
(Date:7/5/2017)... England , July 5, 2017 Wolfmet ... perfect answer as physics and manufacturing combine to progress molecular ... thyroid, existing SPECT systems are unable to accurately quantify the ... only limited information regarding the success of this radiotherapy treatment ... ...
(Date:7/5/2017)... , July 5, 2017   BioLife Solutions ... developer, manufacturer and marketer of proprietary clinical grade cell ... freeze media ("BioLife"), today announced that it has ... debt holder and largest shareholder, to modify its existing ... Pursuant to the modification, WAVI agreed to exchange its ...
Breaking Medicine Technology: