Navigation Links
Varenicline for smoking cessation linked to increased risk of serious harmful cardiac events
Date:7/4/2011

The use of varenicline to stop smoking is associated with a 72% increased risk of a serious adverse cardiovascular event, states an article in CMAJ (Canadian Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/embargo/cmaj110218.pdf.

Heart disease is a common cause of serious illness and death in smokers and is often a reason for people to stop smoking. Varenicline is one of the most commonly used drugs to help people quit smoking worldwide. When varenicline was launched in 2006, the US Food and Drug Administration (FDA) safety reviewers reported that existing data indicated it could raise the risk of adverse cardiac events. The FDA recently updated the label for Chantix based on a small increased risk of cardiovascular events among smokers with heart disease.

A team of researchers from Johns Hopkins University School of Medicine, Baltimore, Maryland; the University of East Anglia, Norwich, United Kingdom; and Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, sought to investigate the serious cardiac effects of varenicline in tobacco users (smokers or smokeless tobacco users) compared with placebos in clinical trials. They looked at 14 trials that included 8216 patients (4908 people on varenicline and 3308 taking placebos). All trials except one excluded people with a history of heart disease.

In the study, 52 of 4908 (1.06%) participants taking varenicline had adverse events compared with 27 of 3308 (0.82%) participants on placebo. Seven of the 4908 people taking varenicline died compared with 7 of 3308 receiving placebo.

"Among tobacco users varenicline use was associated with a significantly increased risk of serious adverse cardiovascular events greater than 72%," writes Dr. Sonal Singh, Johns Hopkins University School of Medicine, Baltimore, Maryland, with coauthors.

"However, despite achieving more than twofold higher rates of a
'/>"/>

Contact: Kim Barnhardt
kim.barnhardt@cmaj.ca
613-520-7116 x2224
Canadian Medical Association Journal
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Smokers using varenicline to quit the habit at greater risk of heart attack
2. New Report: $1 Cigarette Tax Increase Would Raise $418.8 Million for Texas and Cut Youth Smoking
3. New Report: $1 Cigarette Tax Increase Would Raise $18.6 Million for Montana and Cut Youth Smoking
4. New Report: $1 Cigarette Tax Increase Would Raise $24.8 Million for Wyoming and Cut Youth Smoking
5. New Report: $1 Cigarette Tax Increase Would Raise $43.3 Million for Utah and Cut Youth Smoking
6. New Report: $1 Cigarette Tax Increase Would Raise $113.9 Million for Colorado and Cut Youth Smoking
7. New Report: $1 Cigarette Tax Increase Would Raise $65.3 Million for Iowa and Cut Youth Smoking
8. Quitting smoking especially difficult for select groups
9. New intervention helps Latino parents of asthmatic children quit smoking
10. Warning: Immigrating to North America may foster smoking in children
11. VIDEO from Medialink and American Lung Association: Dont Quit on Your Resolution to Quit Smoking!
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... Recently, Dylan Queen, a famous online ... its collection of discounted prom dresses, most of which ... spokesman of the company, the promotion is valid until ... to expand the UK market. , The prom dresses ... lengths, and styles: A-line strapless, empire strapless chiffon, one ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
(Date:12/25/2014)... 25, 2014 Recently, LunaDress.co.uk has updated its blog ... related accessories. Now, all of the models at LunaDress.co.uk come with ... groom lifts the wedding veil can turn out to be a ... A wedding veil can always bring surprise to a wedding. On ... how to choose veils for a big day . , ...
(Date:12/25/2014)... 25, 2014 (HealthDay News) -- Overeating is common during the ... in moderation, an expert says. "Don,t arrive at a ... if you know you,ll be attending a party, but deprivation ... lead dietitian at Northern Westchester Hospital in Mount Kisco, N.Y., ... eat healthy during the day and even to have a ...
(Date:12/25/2014)... tries its best to translate the experience of dress ... introduced its new collection of 2015 prom dresses, and ... prom outfits are guaranteed to contain the perfect designs ... designed for 2015. Anyone who wants to buy ... before Jan. 26, 2015, the deadline of the promotion. ...
Breaking Medicine News(10 mins):Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Angelweddingdress 2015 Prom Dresses Online Now 2
... informed individuals of recent conflicting news reports on the ongoing Baxter ... was not the cause of death among several patients, but the ... did cause death among patients. , ... Denver, CO ...
... kit is designed to answer questions often asked by denture ... fit better, give me more comfort and less pain?" The ... new always-soft Weber Denture Liner. All loose dentures (false ... this new (Patent Pending) invention. The Weber Denture Liner kit ...
... help docs spot those at risk for dementia, Parkinsons, researchers ... with a disorder that causes them to kick or cry ... or Parkinson,s disease, a new Canadian study suggests. , "It,s ... night," explained study author Dr. Ronald B. Postuma, of McGill ...
... but not help those with heart rhythm problems , , WEDNESDAY, ... reduce the chance of death from heart problems, but it ... analysis shows. , The conclusions are based on a Canadian ... 30,000 people. The study, by a team at the University ...
... stem cells may help link genes to human disorders, , , ... (ES) cells from rats have been derived by University of ... creation of far more effective animal models to study a ... development in stem cell research because we know that rats ...
... in the VIP Room of the Marriott Wardman Park ... of abstracts, the complete program of the Meetings, a ... January 5 through Wednesday, January 7, 7:30 a.m.-5:00 p.m., ... phone number is 202-745-2127. , The annual meetings ...
Cached Medicine News:Health News:LegalView Updates its Baxter Heparin Information Portal with Conflicting News Reports on the Possible Dangers 2Health News:LegalView Updates its Baxter Heparin Information Portal with Conflicting News Reports on the Possible Dangers 3Health News:LegalView Updates its Baxter Heparin Information Portal with Conflicting News Reports on the Possible Dangers 4Health News:New Product Makes Loose Dentures Fit Better 2Health News:New Product Makes Loose Dentures Fit Better 3Health News:Sleep Disorder Could Signal Neurological Disease 2Health News:Scientists Create New Means to Study Disease Origins 2Health News:Joint Mathematics Meetings in Washington, D.C. 2Health News:Joint Mathematics Meetings in Washington, D.C. 3Health News:Joint Mathematics Meetings in Washington, D.C. 4Health News:Joint Mathematics Meetings in Washington, D.C. 5Health News:Joint Mathematics Meetings in Washington, D.C. 6Health News:Joint Mathematics Meetings in Washington, D.C. 7Health News:Joint Mathematics Meetings in Washington, D.C. 8Health News:Joint Mathematics Meetings in Washington, D.C. 9Health News:Joint Mathematics Meetings in Washington, D.C. 10
(Date:12/24/2014)...  Actavis plc (NYSE: ACT ) ... complete response letter from the U.S. Food and ... (NDA) for the fixed-dose combination (FDC) of nebivolol ... Photo - http://photos.prnewswire.com/prnh/20130124/NY47381LOGO ... of a complete response letter, Actavis remains committed ...
(Date:12/24/2014)...  The International Trade Commission (ITC) issued its final decision ... In a notice issued on December 23, the ITC ruled ... its humidifier was invalid. BMC President, James ... very excited with the ITC,s decision in this case. This ... since the very beginning on the key patents in the ...
(Date:12/24/2014)... PuraMed BioScience®, Inc., (OTC Pink: PMBS), a ... healthcare products, announced it received the initial funding to ... headache relief product, for planned distribution to 1,000 medical ... , Washington State , and ... H Advanced headache relief gel formulation completed, PuraMed BioScience ...
Breaking Medicine Technology:Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 2Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 3Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 4ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3
Small size means convenient set up in any cath lab. ,System so versatile it can be mounted on I.V. pole or bedside, or bagged in sterile field....
... Used for vascular access. Hollow ... single wall puncture with two-part ... is visualized while maintaining thumb ... exits the hub of the ...
Used for placement of .035 inch (0.89 mm) or .038 inch (0.97 mm) diameter wire guides into the vascular system when a small 21 gage needle stick is desired....
Used to introduce balloon, electrode, closed or non-tapered end catheters and other devices for intervention....
Medicine Products: