Navigation Links
Vandetanib shows clinical benefit when combined with docetaxel for lung cancer
Date:6/4/2010

HOUSTON - When combined with standard chemotherapy, an international Phase III trial has shown that the oral targeted therapy vandetanib improves progression-free survival for patients with advanced non-small cell lung cancer, according to research from The University of Texas MD Anderson Cancer Center.

The findings, published in the Lancet Oncology, mark the first clinical benefit of a small molecule targeted agent and standard chemotherapy in combination for lung cancer. The study was first presented at the 2009 Annual Meeting of the American Society of Clinical Oncology.

"This study shows that an oral tyrosine kinase inhibitor can be combined with chemotherapy safely and effectively to provide systematic benefit to patients with this life-threatening disease," said Roy Herbst, M.D., Ph.D., professor and chief of the section of MD Anderson's Department of Thoracic/Head and Neck Medical Oncology and the study's corresponding author. "Still, we need to build on this research and turn our focus toward better identifying molecular markers involved, with the ultimate goal of personalizing our patient's care."

The therapy is unique in that it's a dual inhibitor and targets the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR). It is the first single agent in lung cancer to target both receptors, said Herbst, the study's international principal investigator.

"Both receptors are active in lung cancer. EGFR targets the tumor cell and VEGF targets the blood vessels, so, with vandetanib, we're really targeting the entire tumor environment at the same time," explained Herbst. "As a dual inhibitor, it also may provide cost-savings to patients in that they can now potentially take one therapy instead of two."

According to the American Cancer Society, lung cancer accounts for the most cancer-related deaths. In 2009, approximately 219,440 were diagnosed and 159,390 died from
'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Spending time in nature makes people feel more alive, study shows
2. Targeted immunotherapy shows promise for metastatic breast, pancreatic cancers
3. Prostate Cancer Vaccine Shows Few Side Effects
4. Brief Exercise Reduces Impact of Stress on Cell Aging, UCSF Study Shows
5. Landmark Clinical Trial Shows Surgery and Stenting Equally Safe and Effective at Preventing Stroke
6. Shark cartilage shows no benefit as a therapeutic agent for lung cancer
7. Gene Therapy Shows Promise for Muscular Dystrophy
8. CA-125 change over time shows promise as screening tool for early detection of ovarian cancer
9. Fat in Males, Females Differs Genetically, Mouse Study Shows
10. Social Media Driving Leads & Sales, New Report Shows
11. Drug in new class of targeted therapies shows early promise against blood-related cancers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vandetanib shows clinical benefit when combined with docetaxel for lung cancer
(Date:12/20/2014)... December 20, 2014 DePuy Pinnacle ... metal-on-metal version of the artificial hip system was ... and federal courts, Bernstein Liebhard LLP reports. According ... County Superior Court on December 2nd, counsel in ... deposition of plaintiffs on November 19, 2014, with ...
(Date:12/20/2014)... December 20, 2014 Recently, VogueQueen.com, a ... VogueQueen Big Sale Online for 2015. Great ... All new and old consumers can get a discount, ... at the company’s website before January 30, 2015. , ... dresses and launched a prom dress promotion. Many customers ...
(Date:12/20/2014)... York, New York (PRWEB) December 20, 2014 ... continue to move forward in U.S. courts, ... new study which suggests that children treated with ... a hormone linked to breast development and lactation. ... looked at 34 children and adolescents who began ...
(Date:12/20/2014)... Recently, AngelWeddingDress.com has introduced its special offer (called ... Christmas. In the promotion, all buyers worldwide can enjoy ... something special for the women who are looking for ... new collections of 2015 dresses have been unveiled recently. ... discounted prices. Visit our website now before they are ...
(Date:12/20/2014)... Twin Cities DI Day is recognized as the premier ... financial professionals come together each year to hear up ... to protect their clients and to be inspired by ... of disability. , On September 23rd, 2014, financial professionals ... The 13th Annual Twin Cities DI Day where they ...
Breaking Medicine News(10 mins):Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 2Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 3Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 4Health News:VogueQueen Big Sale Online For The Coming 2015 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 3Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 4Health News:AngelWeddingDress Has Introduced Its Special Offer For The Coming Christmas 2Health News:The 13th Annual Twin Cities DI Day Now On Video 2Health News:The 13th Annual Twin Cities DI Day Now On Video 3
... 31 The following,is being released by the Campaign ... from across New Jersey express strong support,for 100 percent ... to 28 percent), voters support extending the statewide Smoke-Free,Air ... from a,broad-based coalition of voters across the state, including ...
... data finds no link to most common illnesses , ... do not increase the risk of cancers, connective tissue ... researchers. , A team from the International Epidemiology Institute ... in Nashville, Tenn., reviewed available research on the safety ...
... 31, 2007 A new study appearing in International ... anti-cancer agent that prevents tumor growth by interfering with ... potential to improve the efficacy of standard combination chemotherapy ... most common cancer in women, accounting for nearly 14,000 ...
... month of November,American Diabetes Month, the Erectile Dysfunction ... (ED) to ask,their doctor about being screened for ... under-discussed complication of,diabetes," states Dr. Ananda Basu, an ... don,t realize is that coronary heart disease,is the ...
... LAKE FOREST, Ill, Oct. 31 Hospira, Inc.,(NYSE: ... today,that Thomas E. Werner, senior vice president, Finance, and ... Credit Suisse Phoenix,Health Care Conference on Tuesday, Nov. 13, ... to all interested parties at noon,Mountain Time on Tuesday, ...
... wellness ... options, CAMP HILL, ... linked to lifestyle. In fact, half of the two,million premature deaths that ... poor nutrition, and lack of,exercise -- are a primary reason for rising ...
Cached Medicine News:Health News:New Poll Finds Nearly Seven in 10 New Jersey Voters Support Smoke-Free Casinos 2Health News:New Poll Finds Nearly Seven in 10 New Jersey Voters Support Smoke-Free Casinos 3Health News:Little Evidence Silicone Breast Implants Harm Health 2Health News:Diabetic Men With Erectile Dysfunction Urged to Consult Their Doctors During November - American Diabetes Month 2Health News:Hospira to Present at the Credit Suisse Phoenix Health Care Conference on November 13 2Health News:Highmark Blue Shield Program Rewards Members for Enhancing their 'Healthstyle' 2Health News:Highmark Blue Shield Program Rewards Members for Enhancing their 'Healthstyle' 3
(Date:12/19/2014)... HILL, N.C. , Dec. 19, 2014 /PRNewswire/ ... to optimize a product,s web presence to reflect ... Brand websites, in particular, must meet the needs ... regulations and culture. According to ... more than half of the participating companies averaged ...
(Date:12/19/2014)... Dec. 19, 2014  Monarch America Inc. (OTCQB: CANK) ... is pleased to provide this review of the Company,s ... 2015. "Over this past year, we achieved ... am extremely proud to say that Monarch America is ... it has ever been," stated Eric Hagen , ...
(Date:12/19/2014)... WORTH, Texas , December 18, 2014 /PRNewswire/ ... a networked software application/module that is used to ... related images. RIS comprises a patient tracking and ... system. The integration of RIS with HIS and ... used for patient registration and patient scheduling, patient ...
Breaking Medicine Technology:Building a Best-in-Class Pharma Global Brand Website 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 3
... For Judith Talnadge, a power wheelchair provided through Medicare ... with opportunities to visit with friends and engage in ... Those starkly different living environments are ... who suffers from muscular dystrophy and spina bifida.  These ...
... Optimer Pharmaceuticals, Inc. (NASDAQ: OPTR ) today announced its ... Optimer reported net income for the first quarter of 2011 of ... respectively, as compared to a net loss for the first quarter ... a basic and diluted basis.  The increase in net income was ...
Cached Medicine Technology:Power Wheelchairs Keep Medicare Beneficiaries Out of Nursing Homes, While Reducing Government Costs and Providing More Freedom and Independence 2Power Wheelchairs Keep Medicare Beneficiaries Out of Nursing Homes, While Reducing Government Costs and Providing More Freedom and Independence 3Power Wheelchairs Keep Medicare Beneficiaries Out of Nursing Homes, While Reducing Government Costs and Providing More Freedom and Independence 4Optimer Pharmaceuticals Reports First Quarter 2011 Financial Results 2Optimer Pharmaceuticals Reports First Quarter 2011 Financial Results 3Optimer Pharmaceuticals Reports First Quarter 2011 Financial Results 4Optimer Pharmaceuticals Reports First Quarter 2011 Financial Results 5Optimer Pharmaceuticals Reports First Quarter 2011 Financial Results 6
This high technology cast plaster cutter saw is very easy and comfortable to use....
... a minimum results in less emotional trauma ... the clinician. The innovative motor plus saw ... lighter package. In addition, the unique design ... more user comfort. Plus automated multi-speed controls ...
The True/Fix Cannulated Bone Screw System contains 7.0mm large cannulated bone screws and 3.5mm cortical and 4.0mm cannulated cancellous bone screws....
LEMAIRE stapes are stainless steel staples indicated for ligament fixation....
Medicine Products: