Navigation Links
Vandetanib in thyroid cancer: Added benefit not proven
Date:8/2/2013

Vandetanib (trade name: Caprelsa) has been approved in Germany since February 2012 for the treatment of adult patients who have a particular form of aggressive thyroid cancer. In a new benefit assessment, the German Institute for Quality and Efficiency in Health Care (IQWiG) has now examined the added benefit of the drug pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG).

There is a hint that pain occurs later or gets worse later in a part of the patients, the ones aged under 65 years.But because of the overall poor data on side effects, no conclusion could be drawn about harm. Therefore it was not possible to balance positive and negative effects. Overall, an added benefit of vandetanib is therefore not proven.

Contents of the first dossier on vandetanib were incomplete

Vandetanib underwent a first early benefit assessment procedure in 2012. In this procedure, the drug manufacturer did not present any data for the patients for whom the drug is approved. The added benefit was regarded as not proven because the contents of the dossier were incomplete. The pharmaceutical company could apply for a reassessment of vandetanib within a transition period and submit a new dossier to the Federal Joint Committee (G-BA).

"Best supportive care" as the appropriate comparator therapy

In the newly submitted dossier, the company now presented an analysis of data for patients who were treated according to the approval status. As specified by the G-BA, vandetanib was compared with "best supportive care". This means the best possible supportive therapy, optimized for the individual patient for alleviation of symptoms and improvement in the quality of life.

The only study relevant for the benefit assessment, the approval study, compared the administration of vandetanib in combination with "best supportive care" with a treatment consisting of "best supportive care" in combination with
'/>"/>

Contact: Press Contact
presse@iqwig.de
49-022-135-6850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Vandetanib in thyroid cancer: No proof of added benefit
2. Thyroid Condition Linked to Heart Problems: Study
3. Lower-Dose Radioiodine Effective Against Thyroid Cancer
4. Staging and risk stratification of thyroid cancer improved with SPECT/CT
5. Obese More Likely to Be Diagnosed With Advanced Thyroid Cancer
6. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
7. Hyperthyroidism linked to increased risk of hospitalization for heart and blood-vessel disease
8. Gene expression test identifies low-risk thyroid nodules
9. Detecting thyroid disease by computer
10. Experts issue recommendations for treating thyroid dysfunction during and after pregnancy
11. Drug May Aid People With Advanced Thyroid Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... ... ... The 28th annual Charity Horse Show hosted by the Mid-South Horse Show ... in Pugh Bourne Park, 343 Oakfield Road. The event will again benefit Youth Town. ... a silent auction and concessions. , Horses and riders from around the country will ...
(Date:7/1/2015)... ... July 01, 2015 , ... As if mood swings, ... in a significant number of women: leg pain. Northeast Houston Vein Center is offering ... a symptom of venous reflux disease, is underdiagnosed and often overlooked. Many women experience ...
(Date:7/1/2015)... ... July 01, 2015 , ... “Well-meaning social policy often has ... in FIU’s School of International and Public Affairs. , The researchers ... the National Survey on Drug Use and Health, which is a nationally representative ...
(Date:7/1/2015)... KY (PRWEB) , ... July 01, 2015 , ... ... Care Transformation Task Force, contributing to newly released white paper: “Pro-actively Identifying the ... paper was published July 1st and is available at: http://www.hcttf.org/resouces-tools . , ...
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... ... solution provider of IBM software products, announced today that it has received trademark ... the integration, display and detailed analysis of data from multiple sources providing an ...
Breaking Medicine News(10 mins):Health News:Northeast Houston Vein Center Offers Tips for Women with Leg Pain 2Health News:Northeast Houston Vein Center Offers Tips for Women with Leg Pain 3Health News:Researchers find that medical marijuana laws increase recreational marijuana use among juveniles 2Health News:A Population Based Approach to Pay for Value: RowdMap, Inc. Contributes to Health Care Transformation Task Force White Paper 2Health News:A Population Based Approach to Pay for Value: RowdMap, Inc. Contributes to Health Care Transformation Task Force White Paper 3Health News:Element Blue Receives Trademark Protection from U.S. Patent and Trademark Office for Its Award Winning SensorInsight® Software 2Health News:Element Blue Receives Trademark Protection from U.S. Patent and Trademark Office for Its Award Winning SensorInsight® Software 3Health News:Element Blue Receives Trademark Protection from U.S. Patent and Trademark Office for Its Award Winning SensorInsight® Software 4
... HealthDay Reporter , TUESDAY, Feb. 15 (HealthDay News) ... common than thought among high school athletes, especially among ... finds. "The risk is that we,re often dealing ... perfect their performance, and sometimes they overdo it," said ...
... The Department of Orthopaedic Surgery at NYU Langone Medical ... centers across the country to participate in the American ... independent, not-for-profit organization created to collect key joint replacement ... device performance and identify underperforming processes while providing information ...
... in reducing risk for acquiring HAIs , Study shows 64 percent ... for both ICU and general medical unit patients ... found a reduced risk of hospital-acquired infections (HAI) when using two ... and water. The study found a 64 percent decrease in the ...
... A new study led by an NYU School of Medicine ... Publication, International Journal of Obesity , challenges the idea ... of teenagers or what parents purchase for their children. Teens ... as adults, however they respond at a lower rate. The ...
... HealthDay Reporter , MONDAY, Feb. 14 (HealthDay News) -- Eating ... dying from heart disease, respiratory disease or any other cause ... report. Fiber has also been tied to a reduced ... the researchers added. In addition, fiber helps bowel movements and ...
... works in the "real world" may more effectively ... only on findings in clinical research settings, according ... Association,s cardiovascular disease prevention guidelines for women., First ... been primarily based on findings observed in clinical ...
Cached Medicine News:Health News:Stress Fractures Hitting High School Athletes 2Health News:Stress Fractures Hitting High School Athletes 3Health News:NYU Langone Department of Orthopaedic Surgery chosen to participate in joint replacement registry 2Health News:NYU Langone Department of Orthopaedic Surgery chosen to participate in joint replacement registry 3Health News:Using chlorhexidine gluconate baths to reduce hospital-acquired infections 2Health News:Calorie labeling has no effect on teenagers' or parents' food purchases 2Health News:Calorie labeling has no effect on teenagers' or parents' food purchases 3Health News:Diet High in Fiber Might Lengthen Your Life 2Health News:Diet High in Fiber Might Lengthen Your Life 3Health News:Updated heart disease prevention guidelines for women focus more on 'real-world' recommendations 2Health News:Updated heart disease prevention guidelines for women focus more on 'real-world' recommendations 3
(Date:7/1/2015)... Research and ... of the "2015 New Frontiers in ... Challenges, Emerging Technologies, Competitive Landscape" report ... Frontiers in European Clinical Chemistry and Immunodiagnostic ... is a new five-country strategic analysis of ...
(Date:7/1/2015)... , July 1, 2015  Echo Therapeutics, ... company focused on non-invasive continuous glucose monitoring and ... new and completely re-designed corporate website echotx.com ... access to Echo,s technology and enhances the quality ... new website better communicates to prospective customers and ...
(Date:7/1/2015)... -- Unilife Corporation (NASDAQ: UNIS and ASX: UNS), ... systems, announced today that its debt agreement with OrbiMed ... amendment removed a covenant that required Unilife to generate ... during the six months ended June 30, 2015. There ... of the debt agreement as part of this amendment. ...
Breaking Medicine Technology:2015 New Frontiers in European Clinical Chemistry and Immunodiagnostic Markets: Business Challenges, Emerging Technologies, Competitive Landscape 2Echo Therapeutics Announces New Website Launch 2Echo Therapeutics Announces New Website Launch 3Unilife and OrbiMed Amend Debt Financing Agreement 2Unilife and OrbiMed Amend Debt Financing Agreement 3
... Inc. (OTC/BB: TBIO) today announced the ... to aid physicians in the diagnosis of mitochondrial disorders. ... identify mutations in more than 400 genes, and represents ... The announcement was made at the 2011 United Mitochondrial ...
... YORK, June 16, 2011 Reportlinker.com announces that ... its catalogue: UK CT Systems ... http://www.reportlinker.com/p0555197/UK-CT-Systems-–-Market-Trend-Till-2016.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Imaging Short Description ... market data on the CT systems in UK. ...
Cached Medicine Technology:Transgenomic, Inc. Launches Best-in-Class Next-Generation Sequencing Test for Nuclear Mitochondrial Disorders at the 2011 United Mitochondrial Disease Foundation Meeting 2Transgenomic, Inc. Launches Best-in-Class Next-Generation Sequencing Test for Nuclear Mitochondrial Disorders at the 2011 United Mitochondrial Disease Foundation Meeting 3Reportlinker Adds UK CT Systems - Market Trend Till 2016 2
Industry leader in the design and manufacturing of GP Lenses. Abba holds the CLMA seal of excellence award....
... data collection and management ... multiple store environment. Home ... office with the stores ... and inventory reporting, recalls ...
This computerized retail software is aimed for opticians/optometrists, optical chains/1 hr superstores, optical HMOs, and ophthalmology groups....
... SDS Octoplus Ordering/Dispensing has gained recognition as ... lens ordering system. It enables opticians to ... using SDS electronic communications technology. When used ... or 3D frame tracers, lens shapes are ...
Medicine Products: