Navigation Links
Vanderbilt study reveals clues to childhood respiratory virus
Date:2/13/2013

New Vanderbilt-led research published in the Feb. 14 issue of the New England Journal of Medicine has identified the relatively unknown human metapneumovirus (MPV) as the second most common cause of severe bronchiolitis in young children.

Senior author John Williams , M.D., associate professor of Pediatric Infectious Diseases and a well-known expert in MPV research, said it is gratifying to offer a clearer picture of how this virus impacts children.

"We found MPV is as important a cause of respiratory illness as influenza, and caused more illness than the three common types of parainfluenza virus combined. In fact, in young children, the burden of MPV was second only to RSV (respiratory syncytial virus) as a cause of bronchiolitis," Williams said.

The prospective research spanned six years, from 2003 to 2009, and involved samples taken from more than 10,000 children under age 5. The children were hospitalized, treated in an emergency department, or seen in an outpatient clinic with a lower respiratory infection (bronchiolitis).

Lead author Kathryn Edwards, M.D., the Sarah H. Sell and Cornelius Vanderbilt Chair in Pediatrics and director of the Vanderbilt Vaccine Research Program, led the clinical portion of the study while Williams' laboratory tested the samples for their viral content.

Three New Vaccine Surveillance Network (NVSN) sites participated: Rochester, N.Y., Cincinnati and Nashville, making this the largest prospective trial to date to investigate the burden of MPV.

Researchers found MPV tends to affect more children over age 1 than RSV, and while both viral infections strike in late winter or spring, MPV has a seasonal peak that lags behind the typical peak for RSV by about a month. The authors said physicians commonly see patients with this virus, but know little about it.

"It is important to understand the burden of disease caused by human metapneumovirus so that we can work on vaccines to prevent them. We want to understand the enemy so that we can counteract it," said Edwards.

MPV was first described in 2001 and there are no specific treatments or vaccines for it other than supportive care for bronchiolitis, such as oxygen, bronchodilators and intravenous fluids. No children involved in this study died from their infections. Williams said this is generally true for all the major causes of bronchiolitis in the United States because of the level of medical care available in this country.

"But in developing nations worldwide, lower respiratory illness is a leading cause of death in young children. Only diarrhea kills more children under the age of 5. We can infer, because of this study, that MPV is a major contributor to these deaths worldwide. We hope this will help stimulate more interest in research on vaccines and treatment for MPV," Williams said.


'/>"/>

Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Related medicine news :

1. Vanderbilt study examines Affordable Care Acts impact on uncompensated care
2. Vanderbilt study finds diverse genetic alterations in triple-negative breast cancers
3. UNC, Vanderbilt discover a new live vaccine approach for SARS and novel coronaviruses
4. Vanderbilt study looks at benefits of progestogens to prevent early childbirth
5. Vanderbilt-led study reveals racial disparities in prostate cancer care
6. Vanderbilt researchers find proteins may point way to new prostate cancer drug targets
7. Vanderbilt study finds obesity linked to kidney injury after heart surgery
8. Outdoor Fast-Food Ads Linked to Obesity, Study Suggests
9. Key molecule suppresses growth of cancerous liver tumors, Mayo study finds
10. Cyberbullying as Harmful as Physical Threats, Study Finds
11. MIND Institute researchers receive $1 million grant to study cognitive training in fragile X
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, ... Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments in ... the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... ... is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. ... articles published in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. ...
(Date:6/24/2016)... ... ... National recruitment firm Slone Partners is pleased to announce the ... as Vice President of North American Capital Sales at HTG Molecular . ... team in the commercialization of the HTG EdgeSeq system and associated reagents in North ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... inhaled drugs, announced today that it was added to ... its comprehensive set of U.S. and global equity ... an important milestone for Pulmatrix," said Chief Executive Officer ... of our progress in developing drugs for crucial unmet ...
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
Breaking Medicine Technology: