Navigation Links
Vanderbilt study finds obesity linked to kidney injury after heart surgery
Date:7/5/2012

Obesity increases the risk of acute kidney injury (AKI) following cardiac surgery, according to a Vanderbilt study published in the Journal of the American Society of Nephrology.

Considered common after cardiac surgery, AKI represents a fivefold increase in mortality risk within 30 days after the procedure and is associated with longer hospital stays and a range of complications.

The study, led by anesthesiologist Frederic T. (Josh) Billings IV, M.D., M.Sc., followed a sample of 455 cardiac surgery patients at Vanderbilt University Hospital and Brigham and Women's Hospital in Boston. Some 25 percent of the patients developed AKI after their procedure.

The study found that patients with a higher body mass index (BMI) had a much greater risk. After adjusting for several other risk factors, the odds of AKI increased a staggering 26.5 percent for every five-point increase in a patient's BMI.

Billings and colleagues used a statistical technique called mediation analysis to discover that oxidative stress could be the mechanism by which obesity influences acute kidney injury. Oxidative stress is the toxic overabundance of reactive oxygen species, brought on by excess generation or insufficient elimination.

"By identification of this mechanism, we now may be able to target intraoperative oxidative stress with the hope of reducing kidney injury following cardiac surgery. That may be particularly appropriate for obese individuals," Billings said.

The authors noted that the finding is "consistent with the hypothesis that oxidative stress partially mediates the association between BMI and AKI."

"I think we learned something really important by doing the mediation analysis," said biostatistician Jonathan Schildcrout, Ph.D., one of the study's authors. "You could have just examined the BMI and AKI association, and everybody would have said, 'OK, obese people have higher risk of AKI.'

"When you learn the mechanism, you can start to learn how to intervene to prevent the injury," Schildcrout said.


'/>"/>

Contact: Ashley Culver
ashley.culver@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Related medicine news :

1. Study finds drug warning labels need overhaul to better capture attention, convey information
2. University of Louisville study dispels concerns about drive-thru flu clinics
3. Post-Op Deliriums Toll on Mental Function May Linger: Study
4. Single-Embryo IVF Cuts Risk to Baby: Study
5. Heavy Coffee Intake May Affect Fertility Treatments: Study
6. New study finds increase in track-related injuries among youth in the United States
7. A study demonstrates that ibuprofen improves bone repair after surgery or a fracture
8. Study: Kids with behavior problems, disabilities bullied more, more likely to bully others
9. Kids Born Even a Little Early Have Lower School Scores: Study
10. Spanking Batters Kids Mental Health: Study
11. Moffitt Cancer Center study validates activity of rare genetic variant in glioma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... January 24, 2017 , ... ... that its annual Solutions Series of webinars will start January 31 with a ... a number of current health and benefits topics, including employee engagement, pricing transparency, ...
(Date:1/24/2017)... ... January 24, 2017 , ... This Saturday, January 28, the BCFA presents ... special performance by Alabama Symphony Orchestra musicians Yifan Zhou, Mara McClain & Sarah Nordlund ... sum, and exhibitors offer a look at Chinese games, crafts & more. Festivities begin ...
(Date:1/24/2017)... Switzerland (PRWEB) , ... January 24, 2017 , ... The ... National Metrology Institutes (NMIs) and co-funded by the European Union (EU), was completed in ... in a vacuum, instead being maintained and used in air, which presents some challenges ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... ... a leading natural supplement for relieving premenstrual syndrome, or PMS . , ... some point. These symptoms can include cramps, constipation, irritability, headaches, fatigue, and other ...
(Date:1/24/2017)... , ... January 24, 2017 , ... “Mysteries Revealed On ... be a mysterious phenomenon is available to all Christians. “Mysteries Revealed On Speaking In ... of “U Beautiful Creation,” a Christian-based talk show located in Michigan. , “We ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... January 24, 2017 www.Financialbuzz.com ... industries in the United States as ... 2016. In addition, Proposition 64, the California Cannabis Legalization Initiative, ... against on November 8, 2016. This outcome means that individuals ... and to grow a certain amount of cannabis for personal ...
(Date:1/24/2017)... , Jan. 24, 2017   QR Pharma ... company developing novel therapies for the treatment of ... the appointment of four world-class key opinion leaders ... appointments join QR Pharma,s previous roster of impressive ... direction to support the development of the breakthrough ...
(Date:1/24/2017)... 2017 Mezzion has filed a suit for ... alleging that Dr. Reddy,s committed fraud relating to Dr. ... Administration (FDA) cGMP practices, and misrepresenting its compliance to ... to Mezzion that it was compliant with FDA regulations, ... suit also states that Dr. Reddy,s misconduct was the ...
Breaking Medicine Technology: