Navigation Links
Vanderbilt study finds obesity linked to kidney injury after heart surgery

Obesity increases the risk of acute kidney injury (AKI) following cardiac surgery, according to a Vanderbilt study published in the Journal of the American Society of Nephrology.

Considered common after cardiac surgery, AKI represents a fivefold increase in mortality risk within 30 days after the procedure and is associated with longer hospital stays and a range of complications.

The study, led by anesthesiologist Frederic T. (Josh) Billings IV, M.D., M.Sc., followed a sample of 455 cardiac surgery patients at Vanderbilt University Hospital and Brigham and Women's Hospital in Boston. Some 25 percent of the patients developed AKI after their procedure.

The study found that patients with a higher body mass index (BMI) had a much greater risk. After adjusting for several other risk factors, the odds of AKI increased a staggering 26.5 percent for every five-point increase in a patient's BMI.

Billings and colleagues used a statistical technique called mediation analysis to discover that oxidative stress could be the mechanism by which obesity influences acute kidney injury. Oxidative stress is the toxic overabundance of reactive oxygen species, brought on by excess generation or insufficient elimination.

"By identification of this mechanism, we now may be able to target intraoperative oxidative stress with the hope of reducing kidney injury following cardiac surgery. That may be particularly appropriate for obese individuals," Billings said.

The authors noted that the finding is "consistent with the hypothesis that oxidative stress partially mediates the association between BMI and AKI."

"I think we learned something really important by doing the mediation analysis," said biostatistician Jonathan Schildcrout, Ph.D., one of the study's authors. "You could have just examined the BMI and AKI association, and everybody would have said, 'OK, obese people have higher risk of AKI.'

"When you learn the mechanism, you can start to learn how to intervene to prevent the injury," Schildcrout said.


Contact: Ashley Culver
Vanderbilt University Medical Center

Related medicine news :

1. Study finds drug warning labels need overhaul to better capture attention, convey information
2. University of Louisville study dispels concerns about drive-thru flu clinics
3. Post-Op Deliriums Toll on Mental Function May Linger: Study
4. Single-Embryo IVF Cuts Risk to Baby: Study
5. Heavy Coffee Intake May Affect Fertility Treatments: Study
6. New study finds increase in track-related injuries among youth in the United States
7. A study demonstrates that ibuprofen improves bone repair after surgery or a fracture
8. Study: Kids with behavior problems, disabilities bullied more, more likely to bully others
9. Kids Born Even a Little Early Have Lower School Scores: Study
10. Spanking Batters Kids Mental Health: Study
11. Moffitt Cancer Center study validates activity of rare genetic variant in glioma
Post Your Comments:
(Date:6/27/2016)... , ... June 27, 2016 , ... ... edge technology to revolutionize the emergency ambulance transport experience for the millions of ... of how Uber has disrupted the taxi industry through the use of technology. ...
(Date:6/26/2016)... ... , ... PawPaws brand pet supplements owned by Whole Health Supply ... health of felines. The formula is all-natural and is made from Chinese herbs that ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has ... Global Analysis (United States, China, Japan, Brazil, United Kingdom, ... their offering. Surgical ... business planners, provides surgical procedure volume data in a ... an in-depth analysis of growth drivers and inhibitors, including ...
(Date:6/23/2016)... -- The Biotechnology industry might still be ... opportunities to investors. assesses the recent performances of ... XON ), Vertex Pharmaceuticals Inc. (NASDAQ: ... ), and Regeneron Pharmaceuticals Inc. (NASDAQ: REGN ... complimentary trade alerts at: ...
(Date:6/23/2016)... Leading BioSciences Inc., a clinical-stage biopharmaceutical ... from a breakdown of the mucosal barrier, today ... as chief executive officer. Mr. Doyle, a ... and board of directors, previously served as chief ... provide continued leadership and strategic direction to the ...
Breaking Medicine Technology: