Navigation Links
Vanderbilt study explores genetics behind Alzheimer's resiliency
Date:5/2/2014

Autopsies have revealed that some individuals develop the cellular changes indicative of Alzheimer's disease without ever showing clinical symptoms in their lifetime.

Vanderbilt University Medical Center memory researchers have discovered a potential genetic variant in these asymptomatic individuals that may make brains more resilient against Alzheimer's.

"Most Alzheimer's research is searching for genes that predict the disease, but we're taking a different approach. We're looking for genes that predict who among those with Alzheimer's pathology will actually show clinical symptoms of the disease," said principal investigator Timothy Hohman, Ph.D., a post-doctoral research fellow in the Center for Human Genetics Research and the Vanderbilt Memory and Alzheimer's Center.

The article, "Genetic modification of the relationship between phosphorylated tau and neurodegeneration," was published online recently in the journal Alzheimer's and Dementia.

The researchers used a marker of Alzheimer's disease found in cerebrospinal fluid called phosphorylated tau. In brain cells, tau is a protein that stabilizes the highways of cellular transport in neurons. In Alzheimer's disease tau forms "tangles" that disrupt cellular messages.

Analyzing a sample of 700 subjects from the Alzheimer's Disease Neuroimaging Initiative, Hohman and colleagues looked for genetic variants that modify the relationship between phosphorylated tau and lateral ventricle dilation a measure of disease progression visible with magnetic resonance imaging (MRI). One genetic mutation (rs4728029) was found to relate to both ventricle dilation and cognition and is a marker of neuroinflammation.

"This gene marker appears to be related to an inflammatory response in the presence of phosphorylated tau," Hohman said.

"It appears that certain individuals with a genetic predisposition toward a 'bad' neuroinflammatory response have neurodegeneration. But those with a genetic predisposition toward no inflammatory response, or a reduced one, are able to endure the pathology without marked neurodegeneration."

Hohman hopes to expand the study to include a larger sample and investigate gene and protein expression using data from a large autopsy study of Alzheimer's disease.

"The work highlights the possible mechanism behind asymptomatic Alzheimer's disease, and with that mechanism we may be able to approach intervention from a new perspective. Future interventions may be able to activate these innate response systems that protect against developing Alzheimer's symptoms," Hohman said.


'/>"/>

Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Related medicine news :

1. Vanderbilt study finds physical signs of depression common among ICU survivors
2. Vanderbilt study: Ancient chemical bond may aid cancer therapy
3. Vanderbilt study finds limited resources for injured surgeons
4. AxoGen, Inc. Receives Grant in Partnership with Vanderbilt University from U.S. Department of Defense
5. Vanderbilt study finds lack of exercise not a factor in health disparities
6. Vanderbilt study finds maternal diet important predictor of severity for infant RSV
7. Vanderbilt study reveals clues to childhood respiratory virus
8. Vanderbilt study examines Affordable Care Acts impact on uncompensated care
9. Vanderbilt study finds diverse genetic alterations in triple-negative breast cancers
10. UNC, Vanderbilt discover a new live vaccine approach for SARS and novel coronaviruses
11. Vanderbilt study looks at benefits of progestogens to prevent early childbirth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... South Bend’s Lunkerville, the award-winning ... again feature Heroes On The Water (HOW), a non-profit organization dedicated to helping military ... has series host ‘Mike D’ traveling to Lake Denmark, New Jersey, to fish with ...
(Date:2/22/2017)... ... 22, 2017 , ... In a 2012 survey, over a ... filling a prescription because they could not afford to pay for it. Among ... 30-60%*. At the same time, hospitals, pharmacies, manufacturers and nursing homes ...
(Date:2/22/2017)... Shrewsbury, PA (PRWEB) , ... February 22, 2017 , ... ... 2017 where the company met national TV host Tom Seay and his production crew. ... is a favorite among equestrians around the world. Saddle Sidekicks will be featured ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... celebrated throughout the country today, as organizations, advocates, and individuals join together to ... and treatment access to ultimately save lives. , “Today we mark a nationwide ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... related to spine practices, is featuring Michigan neurosurgeon Jay Jagannathan, M.D., as a ... of a small number of neurosurgeons in Michigan performing minimally invasive back surgery ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... Feb. 22, 2017 Summary ... deals and agreements entered into by the worlds ... http://www.reportlinker.com/p03605675-summary/view-report.html Description The Global Atherosclerosis ... understanding and access to partnering deals and agreements ... - Trends in partnering deals ...
(Date:2/22/2017)... , Feb. 22, 2017 Summary ... disease partnering deals and agreements entered into by the ... http://www.reportlinker.com/p03605682-summary/view-report.html Description The Global Motor Neurone ... understanding and access to partnering deals and agreements entered ... - Trends in partnering deals - Top deals ...
(Date:2/22/2017)... ALBANY, New York , February 22, 2017 ... leading the global automated microscopy market are Olympus ... companies held a share or 75% in the ... likely to witness tremendous product innovation through result-oriented ... Several players are also expected to focus on ...
Breaking Medicine Technology: