Navigation Links
Vanderbilt study: Ancient chemical bond may aid cancer therapy
Date:12/16/2013

A chemical bond discovered by Vanderbilt University scientists that is essential for animal life and which hastened the "dawn of the animal kingdom" could lead to new therapies for cancer and other diseases.

The report, published online today by the Proceedings of the National Academy of Sciences(PNAS), was co-authored by 83 participants in the "Aspirnaut" K-20 STEM pipeline program for diversity. Six were middle school students when the study was conducted, 42 were high school students, 30 were college undergraduates and five were graduate students.

Because many of the high school students grew up in poverty in rural communities, "they're invisible. They're an untapped talent pool," said Billy Hudson, Ph.D., who founded the Aspirnaut program with his wife and co-senior author Julie Hudson, M.D. "Aspirnaut connects the 'Forgotten Student' to STEM opportunities."

The study demonstrates that the sulfilimine bond, which Hudson's group discovered in 2009, is part of a "primordial innovation" dating back more than 500 million years to the ancestor of jellyfish. The bond stabilizes the collagen IV scaffold and is essential for more advanced tissue formation.

The bond is formed by hypohalous acids, a form of household bleach, generated by peroxidasin, an ancient enzyme embedded in the extracellular environment. This "oxidant generator" is key to forming new blood vessels that feed tumors, making it an attractive target for developing new drugs for cancer therapy, the researchers said.

The involvement of so many young students in a scientific publication is "rare, the first that I know of," said PNAS Editor-in-Chief Inder Verma, Ph.D. "It is a remarkable achievement," added Mina Bissell, Ph.D., who conducted the initial review of the manuscript for the journal.

During the summers of 2009 to 2013, the students participated in an "Expedition to the Dawn of the Animal Kingdom," a summer research program at Vanderbilt to search for the evolutionary origin of the sulfilimine chemical bond.

They contributed to experiments that showed the sulfilimine bond and the peroxidasin-based mechanism by which it forms can be traced to a common ancestor dating back more than 500 million years ago.

Of the 42 high-school researchers, 31 have now graduated. Thirty are attending or have completed college, 26 with STEM (science, technology, engineering and mathematics) majors.


'/>"/>

Contact: Craig Boerner
criag.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Related medicine news :

1. Vanderbilt study finds limited resources for injured surgeons
2. AxoGen, Inc. Receives Grant in Partnership with Vanderbilt University from U.S. Department of Defense
3. Vanderbilt study finds lack of exercise not a factor in health disparities
4. Vanderbilt study finds maternal diet important predictor of severity for infant RSV
5. Vanderbilt study reveals clues to childhood respiratory virus
6. Vanderbilt study examines Affordable Care Acts impact on uncompensated care
7. Vanderbilt study finds diverse genetic alterations in triple-negative breast cancers
8. UNC, Vanderbilt discover a new live vaccine approach for SARS and novel coronaviruses
9. Vanderbilt study looks at benefits of progestogens to prevent early childbirth
10. Vanderbilt-led study reveals racial disparities in prostate cancer care
11. Vanderbilt researchers find proteins may point way to new prostate cancer drug targets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... The ... Zuckerberg San Francisco General Hospital on April 5-7. The series is a multi-day, ... new habits. The workshops cover a broad range of topics, including coaching skills, ...
(Date:2/12/2016)... ... , ... Every winter, someone is killed, injured or loses a home in ... part of the Allegheny Health Network, has partnered with Etna Volunteer Fire Department, ... Space” campaign. , “Space Heaters Need Space” aims to bring awareness to ...
(Date:2/12/2016)... NC (PRWEB) , ... February 12, 2016 , ... AssureVest ... surrounding areas, is initiating a charity drive that will raise funds earmarked to purchase ... John C. Tayloe Elementary School. , “My school is in a low-income area and ...
(Date:2/12/2016)... Vail, Colorado (PRWEB) , ... February 12, 2016 , ... ... 164 ASC Industry Physician Leaders to Know in 2016 . The list consists of ... leaders nominated physicians to establish this list. , An Ambulatory Surgery Center, also ...
(Date:2/12/2016)... ... February 12, 2016 , ... Young Asset Protection, a full ... of the latest charity campaign in their community enrichment program. Art Expression utilizes ... worthy cause are currently being accepted at: http://artexpressioninc.org/ . , Art Expression ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)...  Kindred Biosciences, Inc. (NASDAQ: KIN ), a ... of pets, today announced the submission to FDA of ... Application (NADA) for Zimeta™ (dipyrone injection, KIND-012).  Positive topline ... for the control of pyrexia (fever) in horses were ... --> The Chemistry, Manufacturing, and Controls ...
(Date:2/11/2016)... 11, 2016  Governor Andrew M. Cuomo today announced ... jobs throughout Western New York . ... SUNY Polytechnic Institute, includes a major expansion of Athenex,s ... Buffalo , as well as the creation ... Dunkirk . The combined projects are ...
(Date:2/11/2016)... SAN FRANCISCO , Feb. 11, 2016 Potrero ... system, is pleased to announce the appointment of George ... San Antonio, TX , WellMed is ... servicing over 200,000 patients and HMO members in ... founding WellMed in 1990 out of his own internal medicine ...
Breaking Medicine Technology: