Navigation Links
Vanderbilt study: Ancient chemical bond may aid cancer therapy
Date:12/16/2013

A chemical bond discovered by Vanderbilt University scientists that is essential for animal life and which hastened the "dawn of the animal kingdom" could lead to new therapies for cancer and other diseases.

The report, published online today by the Proceedings of the National Academy of Sciences(PNAS), was co-authored by 83 participants in the "Aspirnaut" K-20 STEM pipeline program for diversity. Six were middle school students when the study was conducted, 42 were high school students, 30 were college undergraduates and five were graduate students.

Because many of the high school students grew up in poverty in rural communities, "they're invisible. They're an untapped talent pool," said Billy Hudson, Ph.D., who founded the Aspirnaut program with his wife and co-senior author Julie Hudson, M.D. "Aspirnaut connects the 'Forgotten Student' to STEM opportunities."

The study demonstrates that the sulfilimine bond, which Hudson's group discovered in 2009, is part of a "primordial innovation" dating back more than 500 million years to the ancestor of jellyfish. The bond stabilizes the collagen IV scaffold and is essential for more advanced tissue formation.

The bond is formed by hypohalous acids, a form of household bleach, generated by peroxidasin, an ancient enzyme embedded in the extracellular environment. This "oxidant generator" is key to forming new blood vessels that feed tumors, making it an attractive target for developing new drugs for cancer therapy, the researchers said.

The involvement of so many young students in a scientific publication is "rare, the first that I know of," said PNAS Editor-in-Chief Inder Verma, Ph.D. "It is a remarkable achievement," added Mina Bissell, Ph.D., who conducted the initial review of the manuscript for the journal.

During the summers of 2009 to 2013, the students participated in an "Expedition to the Dawn of the Animal Kingdom," a summer research program at Vand
'/>"/>

Contact: Craig Boerner
criag.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Vanderbilt study finds limited resources for injured surgeons
2. AxoGen, Inc. Receives Grant in Partnership with Vanderbilt University from U.S. Department of Defense
3. Vanderbilt study finds lack of exercise not a factor in health disparities
4. Vanderbilt study finds maternal diet important predictor of severity for infant RSV
5. Vanderbilt study reveals clues to childhood respiratory virus
6. Vanderbilt study examines Affordable Care Acts impact on uncompensated care
7. Vanderbilt study finds diverse genetic alterations in triple-negative breast cancers
8. UNC, Vanderbilt discover a new live vaccine approach for SARS and novel coronaviruses
9. Vanderbilt study looks at benefits of progestogens to prevent early childbirth
10. Vanderbilt-led study reveals racial disparities in prostate cancer care
11. Vanderbilt researchers find proteins may point way to new prostate cancer drug targets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... August 28, 2015 , ... Joining a ... Memorial Hospital recently transitioned management companies to partner with Wound Care Advantage (WCA) ... outpatient wound center. , Transitioning wound care management providers can be a ...
(Date:8/28/2015)... ... August 28, 2015 , ... Approximately 2,000 United Methodists ... celebrate children helping children, a thank you to the many creative and generous ... to the United Methodist initiative to end malaria deaths. , The Columbus Zoo ...
(Date:8/28/2015)... ... , ... An article published August 19th by the LA Times ... to open a pizzeria in Westchester. Mr. LaRocco was aware from opening prior pizza ... the current process, having already gone on for over a year, is taking much ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... For Dallas, ... is taking part with their subsidiary USPI Tenet Health. , The American Heart Association ... heart disease and stroke. They believe that together, a difference can be made. Walkers ...
(Date:8/28/2015)... Baltimore, MD (PRWEB) , ... August 28, 2015 , ... ... reduction system from Merz, received FDA clearance for results that last for two ... clearance is exciting news for patients who are looking for a long-lasting, effective solution ...
Breaking Medicine News(10 mins):Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 3Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 4Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:Article on Building Approval Process for LA Business Highlights the Need for a Bridge Between Businesses and City Officials, says Fire Protection Group Inc. 2Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 3
... 1, WASHINGTON, May 1 U.S. Paralympian April ... on the track. In September, she,will travel to Beijing ... favored to medal in the 100- and 200-meter dashes. ... well what working,Americans need to do to keep their ...
... notes, "We make,decisions for the right reasons and then we ... the right time, by the right people, and at the,right ... Management has now grown so much that an increasingly,sophisticated system ... and strategic at its core -- but that is fraught ...
... ... HILLS, Ill. and CORPUS CHRISTI, Texas, May 1 ... from Texas,A&M-Corpus Christi,s Kinesiology Department demonstrated the correlation,between improved ... improvement in the hitting performance of,Islander baseball players after ...
... Texas Cardiac Arrhythmia Recruits and Hires Dr. Andrea ... Executive Medical Director of the Texas Cardiac Arrhythmia,Institute ... May 1 St. David,s HealthCare,along with Texas ... Cardiac Arrhythmia Institute (TCAI) at St. David,s Medical ...
... N.C., May 1 The Oregon State,Supreme Court ... statewide class,action in which plaintiff sought to make ... for medical monitoring of all Oregon,cigarette smokers., ... of the complaint and,the intermediate appellate court,s unanimous ...
... hinder a protein called IGF-1 not entirely successful, studies ... idea that prostate cancer can be treated successfully just ... growth factor (IGF-1) has been undermined by two new ... by a number of drug companies and academic researchers, ...
Cached Medicine News:Health News:U.S. Paralympian April Holmes Teams With LIFE Foundation to Encourage Americans to Assess Their Disability Insurance Needs This May 2Health News:U.S. Paralympian April Holmes Teams With LIFE Foundation to Encourage Americans to Assess Their Disability Insurance Needs This May 3Health News:U.S. Paralympian April Holmes Teams With LIFE Foundation to Encourage Americans to Assess Their Disability Insurance Needs This May 4Health News:Best Practices in Designing Effective Brand Teams 2Health News:Study by Texas A&M University-Corpus Christi Confirms Training With Vision Software Enhances Hitting Skills 2Health News:St. David's HealthCare and Texas Cardiac Arrhythmia Announce International Center For Training, Research and Treatment of Heart Rhythm Disorders 2Health News:St. David's HealthCare and Texas Cardiac Arrhythmia Announce International Center For Training, Research and Treatment of Heart Rhythm Disorders 3Health News:St. David's HealthCare and Texas Cardiac Arrhythmia Announce International Center For Training, Research and Treatment of Heart Rhythm Disorders 4Health News:Complications Found in Proposed Prostate Cancer Treatment 2
(Date:8/28/2015)... , Aug. 28, 2015 ... has announced the addition of the "Investigation ... to their offering. Developed by Pharmacia ... prostaglandin receptor agonist which effectively reduces intraocular pressure. ... FDA, latanoprost (under the trade name of Xalatan) ...
(Date:8/28/2015)... HONG KONG , August 28, 2015 ... Gero in collaboration with one of the leading academics ... Reis (current world record holder in life extension for ... new insights into biology of aging and age-related diseases, primarily, ... networks. The work has just been published as "Stability analysis ...
(Date:8/28/2015)... Perrigo Company plc ("Perrigo") (NYSE: PRGO ... (NASDAQ: MYL ) shareholder vote regarding its planned ... of Mylan,s offer to Perrigo shareholders have always been, ... careful reflection of the value available to Perrigo shareholders, ... Mylan has allowed its shareholders to consider," said ...
Breaking Medicine Technology:China Latanoprost Market Investigation Report 2015-2019 2Gero: Physics Meets Biology to Help Defeat Aging 2Gero: Physics Meets Biology to Help Defeat Aging 3Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 3Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 4Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 5
Catalano straight tying forcep has 6 mm V-grove tying platform. Overall length 100 mm....
McPherson straight tying forceps have straight shafts, tying platforms 4 mm, serrated handle, polished finish, overall length 85 mm....
Jayle tying forceps, straight....
Troutman tying forceps are curved, delicate, bullet shape, with tying platforms. Flat pattern. Ultra fine platforms ideal for 10-0 or 11-0 suture material. Platforms fully meet to hold suture firmly....
Medicine Products: