Navigation Links
Vanderbilt study: Ancient chemical bond may aid cancer therapy
Date:12/16/2013

A chemical bond discovered by Vanderbilt University scientists that is essential for animal life and which hastened the "dawn of the animal kingdom" could lead to new therapies for cancer and other diseases.

The report, published online today by the Proceedings of the National Academy of Sciences(PNAS), was co-authored by 83 participants in the "Aspirnaut" K-20 STEM pipeline program for diversity. Six were middle school students when the study was conducted, 42 were high school students, 30 were college undergraduates and five were graduate students.

Because many of the high school students grew up in poverty in rural communities, "they're invisible. They're an untapped talent pool," said Billy Hudson, Ph.D., who founded the Aspirnaut program with his wife and co-senior author Julie Hudson, M.D. "Aspirnaut connects the 'Forgotten Student' to STEM opportunities."

The study demonstrates that the sulfilimine bond, which Hudson's group discovered in 2009, is part of a "primordial innovation" dating back more than 500 million years to the ancestor of jellyfish. The bond stabilizes the collagen IV scaffold and is essential for more advanced tissue formation.

The bond is formed by hypohalous acids, a form of household bleach, generated by peroxidasin, an ancient enzyme embedded in the extracellular environment. This "oxidant generator" is key to forming new blood vessels that feed tumors, making it an attractive target for developing new drugs for cancer therapy, the researchers said.

The involvement of so many young students in a scientific publication is "rare, the first that I know of," said PNAS Editor-in-Chief Inder Verma, Ph.D. "It is a remarkable achievement," added Mina Bissell, Ph.D., who conducted the initial review of the manuscript for the journal.

During the summers of 2009 to 2013, the students participated in an "Expedition to the Dawn of the Animal Kingdom," a summer research program at Vanderbilt to search for the evolutionary origin of the sulfilimine chemical bond.

They contributed to experiments that showed the sulfilimine bond and the peroxidasin-based mechanism by which it forms can be traced to a common ancestor dating back more than 500 million years ago.

Of the 42 high-school researchers, 31 have now graduated. Thirty are attending or have completed college, 26 with STEM (science, technology, engineering and mathematics) majors.


'/>"/>

Contact: Craig Boerner
criag.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Related medicine news :

1. Vanderbilt study finds limited resources for injured surgeons
2. AxoGen, Inc. Receives Grant in Partnership with Vanderbilt University from U.S. Department of Defense
3. Vanderbilt study finds lack of exercise not a factor in health disparities
4. Vanderbilt study finds maternal diet important predictor of severity for infant RSV
5. Vanderbilt study reveals clues to childhood respiratory virus
6. Vanderbilt study examines Affordable Care Acts impact on uncompensated care
7. Vanderbilt study finds diverse genetic alterations in triple-negative breast cancers
8. UNC, Vanderbilt discover a new live vaccine approach for SARS and novel coronaviruses
9. Vanderbilt study looks at benefits of progestogens to prevent early childbirth
10. Vanderbilt-led study reveals racial disparities in prostate cancer care
11. Vanderbilt researchers find proteins may point way to new prostate cancer drug targets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs ... College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. ... treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016  In a startling report released today, ... residents by lacking a comprehensive, proven plan to eliminate prescription opioid ... ranking of how states are tackling the worst drug crisis in ... states – Kentucky , New Mexico ... . Of the 28 failing states, three – ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
Breaking Medicine Technology: