Navigation Links
Vanderbilt study: Ancient chemical bond may aid cancer therapy
Date:12/16/2013

A chemical bond discovered by Vanderbilt University scientists that is essential for animal life and which hastened the "dawn of the animal kingdom" could lead to new therapies for cancer and other diseases.

The report, published online today by the Proceedings of the National Academy of Sciences(PNAS), was co-authored by 83 participants in the "Aspirnaut" K-20 STEM pipeline program for diversity. Six were middle school students when the study was conducted, 42 were high school students, 30 were college undergraduates and five were graduate students.

Because many of the high school students grew up in poverty in rural communities, "they're invisible. They're an untapped talent pool," said Billy Hudson, Ph.D., who founded the Aspirnaut program with his wife and co-senior author Julie Hudson, M.D. "Aspirnaut connects the 'Forgotten Student' to STEM opportunities."

The study demonstrates that the sulfilimine bond, which Hudson's group discovered in 2009, is part of a "primordial innovation" dating back more than 500 million years to the ancestor of jellyfish. The bond stabilizes the collagen IV scaffold and is essential for more advanced tissue formation.

The bond is formed by hypohalous acids, a form of household bleach, generated by peroxidasin, an ancient enzyme embedded in the extracellular environment. This "oxidant generator" is key to forming new blood vessels that feed tumors, making it an attractive target for developing new drugs for cancer therapy, the researchers said.

The involvement of so many young students in a scientific publication is "rare, the first that I know of," said PNAS Editor-in-Chief Inder Verma, Ph.D. "It is a remarkable achievement," added Mina Bissell, Ph.D., who conducted the initial review of the manuscript for the journal.

During the summers of 2009 to 2013, the students participated in an "Expedition to the Dawn of the Animal Kingdom," a summer research program at Vanderbilt to search for the evolutionary origin of the sulfilimine chemical bond.

They contributed to experiments that showed the sulfilimine bond and the peroxidasin-based mechanism by which it forms can be traced to a common ancestor dating back more than 500 million years ago.

Of the 42 high-school researchers, 31 have now graduated. Thirty are attending or have completed college, 26 with STEM (science, technology, engineering and mathematics) majors.


'/>"/>

Contact: Craig Boerner
criag.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Related medicine news :

1. Vanderbilt study finds limited resources for injured surgeons
2. AxoGen, Inc. Receives Grant in Partnership with Vanderbilt University from U.S. Department of Defense
3. Vanderbilt study finds lack of exercise not a factor in health disparities
4. Vanderbilt study finds maternal diet important predictor of severity for infant RSV
5. Vanderbilt study reveals clues to childhood respiratory virus
6. Vanderbilt study examines Affordable Care Acts impact on uncompensated care
7. Vanderbilt study finds diverse genetic alterations in triple-negative breast cancers
8. UNC, Vanderbilt discover a new live vaccine approach for SARS and novel coronaviruses
9. Vanderbilt study looks at benefits of progestogens to prevent early childbirth
10. Vanderbilt-led study reveals racial disparities in prostate cancer care
11. Vanderbilt researchers find proteins may point way to new prostate cancer drug targets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder ... of ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership ... rules. It also provides a forum to network with elder law attorneys nationwide,” said ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one ... an innovative new design of the shoulder pad. The shoulder pad provides optimal ... controlling your pain while using cold therapy. By utilizing ice and water that is ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare events ... Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the ... The annual award competition recognizes editorial and design excellence across a range of sectors. ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)...  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided ... Piedras, Puerto Rico , where the ... Following a comprehensive onsite ... structural damage, temporary loss of power and minimal water ... manufacturing operations have resumed, and the company expects to ...
(Date:10/10/2017)... Oct. 10, 2017   West Pharmaceutical Services, Inc. ... for injectable drug administration, today shared the results of ... for improving the intradermal administration of polio vaccines. The ... Summit in May 2017 by Dr. Ondrej Mach ... World Health Organization (WHO), and recently published in the ...
(Date:10/5/2017)... , Oct. 5, 2017  In response to ... Oral and Maxillofacial Surgeons (AAOMS) released prescribing recommendations ... to be used as a first-line therapy to ... Recognizing the value ... White Paper "Opioid Prescribing: Acute and Postoperative Pain ...
Breaking Medicine Technology: