Navigation Links
Vanderbilt researchers find proteins may point way to new prostate cancer drug targets
Date:8/6/2012

Two proteins that act in opposing directions one that promotes cancer and one that suppresses cancer regulate the same set of genes in prostate cancer, Vanderbilt-Ingram Cancer Center researchers have found.

The findings, reported recently in the Journal of Clinical Investigation, point toward potential drug targets and prognostic markers for prostate cancer.

"We are trying to understand the molecular genetics of prostate cancer: what are the genes that are altered in human prostate cancer, and very importantly, how do they lead to cancer when they are changed?" said Sarki Abdulkadir, M.D., Ph.D., associate professor of Pathology, Microbiology and Immunology and of Cancer Biology.

Abdulkadir's lab uses mouse models to probe the molecular pathways involved in prostate cancer.

Two separate projects in the lab unexpectedly came together for this study one led by postdoctoral fellow Philip Anderson, Ph.D., and the other spearheaded by (then) graduate student Sydika McKissic, Ph.D.

Anderson was using genomic approaches to understand how loss of a tumor suppressor protein, called NKX3.1, promotes prostate cancer. NKX3.1 is a transcription factor, meaning that it binds to and regulates the expression of other genes, turning them "on" or "off."

"It is one of the genes most commonly deleted in human prostate cancerand is lost very early," explained Abdulkadir.

Anderson isolated the NKX3.1 protein and identified a set of 9,817 genes that bind to the protein. Of that set, he identified 282 genes that are regulated by the protein i.e., their expression was altered by loss of NKX3.1.

"So we took those genes...and asked 'what is interesting about these genes?'" said Abdulkadir.

Using bioinformatics tools, the investigators found a quarter of the NKX3.1-regulated genes are also bound by a "famous" oncogene called Myc (which, like NKX3.1, is also a transcription factor).


'/>"/>
Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Vanderbilt study finds obesity linked to kidney injury after heart surgery
2. NIH awards $20 million over 5 years to train next generation of global health researchers
3. Researchers develop a new cell and animal model of inflammatory breast cancer
4. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
5. Researchers Find Gene Mutations That May Be a Key to Autism
6. Researchers find evidence of banned antibiotics in poultry products
7. NJ stroke researchers report advances in spatial neglect research at AAN Conference
8. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
9. Researchers Map Brain Regions Linked to Intelligence
10. Researchers ID Genes That May Determine Mental Illness
11. Researchers Develop Blood Test for Depression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vanderbilt researchers find proteins may point way to new prostate cancer drug targets
(Date:12/25/2014)... risk of burns from fires and cooking accidents increases ... cautious, an expert says. "Between Thanksgiving and New ... coming in with burns," said Dr. Steven Sandoval, medical ... of Stony Brook University Hospital in New York. ... not careful, could quickly turn tragic," Sandoval said in ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. 24, 2014 (HealthDay ... of youth" drug that can delay the effects of aging ... suggests. Seniors received a significant boost to their immune ... pathway linked to aging and immune function, researchers with the ... a version of the drug rapamycin, improved the seniors, immune ...
(Date:12/25/2014)... ” was featured on NewsWatch as part of its monthly ... the iOS, Android, and Windows markets. Andrew Tropeano, a mobile ... and shared with viewers how this is an application for ... “A picture says a thousand words.” It’s true. There are ... because each picture holds a unique and special meaning. Photos ...
(Date:12/25/2014)... Each year trauma accounts for approximately 42 ... across the nation (according to the Centers for ... Hospital Ambulatory Medical Care Survey collected data from ... They estimated that there were between 3.5 and 4.4 ... diagnosis of broken bone or fracture. , When ...
(Date:12/24/2014)... (PRWEB) December 25, 2014 Over 700 ... to their local communities. That is 700 smiling little ... single gift. Additionally over $6000 in monetary donations was ... offset some of the expenses they incur through the ... drive were A Child's Haven , Shrine's Children's ...
Breaking Medicine News(10 mins):Health News:Don't Let Burns Mar Your Holidays 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4Health News:AlignLife Donates Over 700 Toys This Year 2
... the number of people taking medications or drugs has ... to be noted that combining two or more drugs ... ,Several medications contain active ingredients that can interact ... rule out the risks by paying close attention to ...
... Russia has been witness to the death of more than ... hit the south of Russia.// ,According to the ... 25 and Feb 1, almost 350,000 birds have died at ... at the Makhachkalinskaya farm between Feb. 6 and Feb. 8. ...
... often simple answers that provide effective solutions to major ... disinfection as it has now been found that addition ... can effectively destroy bacterial spores. // ,Researchers ... yet significant solution to bacterial contamination. Sodium hypochlorite or ...
... the possibility of a hemagglutinin gene mutation with respect ... virus. // It is further stated that this mutation ... viral affinity for human receptors. ,The company ... could spark a bird flu pandemic, killing millions worldwide. ...
... could hold the key to killing cancer cells easily with ... of Medicine in St. Louis. Rad9 was previously thought // ... now fund to be a "repairman" for DNA that fixes ... ,That is why reserachers are now looking at Rad9 with ...
... been detected in dead chicken in the western state of ... 50,000 birds are dead, but CNN-IBN reports // quoted Jayant ... are confirmed deaths. ,The Animal Husbandry department said ... virus. The rapid response team has sent five members down ...
Cached Medicine News:Health News:Drug Combinations Could Be Dangerous 2Health News:Genetic Change In The H5N1 Virus Likely: Recombinomics Inc. 2Health News:Switching Off Protein Could Play Key Role In Success Of Radiation Therapy For Cancer 2
(Date:12/24/2014)... Tianyin Pharmaceutical Co., Inc. (NYSE MKT: ... biopharmaceutical, modernized traditional Chinese medicine (mTCM), branded generics ... the Company achieved the Public Notice (Gong Shi) ... of TPI,s Qionglai Facility (QLF) from the China ... period is a significant procedure of GMP certification ...
(Date:12/22/2014)... JUNCTION, N.J. , Dec. 22, 2014 /PRNewswire/ ... company marketing its CytoSorb® blood purification technology to ... surgery patients in 28 countries worldwide, today announced ... Russo , MD, FACS, as its Senior Vice ... Dr. Di Russo ...
(Date:12/22/2014)... --  TRU-D SmartUVC LLC, producers of the first ... that the General Services Administration has awarded the company ... This newly formed agreement will allow TRU-D SmartUVC ... including Department of Veteran Affairs and Department of Defense ... solutions for the Ebola effort in West ...
Breaking Medicine Technology:TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: