Navigation Links
Vanderbilt finding may aid recovery from spinal cord injury

Researchers in the Vanderbilt University Institute of Imaging Science (VUIIS) have achieved the first conclusive non-invasive measurement of neural signaling in the spinal cords of healthy human volunteers.

Their technique, described today in the journal eLife, may aid efforts to help patients recover from spinal cord injuries and other disorders affecting spinal cord function, including multiple sclerosis.

"We definitely hope that this work can be translated to address many neurological disorders," said the paper's first author, Robert Barry, Ph.D., a postdoctoral research fellow in the institute directed by senior author John Gore, Ph.D.

The researchers used ultra-high field functional magnetic resonance imaging (fMRI) to detect for the first time "resting state" signals between neural circuits in the human spinal column. These signals are continuously active, not in response to external stimuli.

"We see these background resting circuits as being inherent measures of function," said Gore, the Hertha Ramsey Cress Professor of Medicine, University Professor and vice chair of Research in the Department of Radiology and Radiological Sciences.

The technique may be valuable for understanding how spinal cord injury changes the "functional connectivity" between neural circuits, for example, and for assessing and monitoring recovery that occurs spontaneously or following various interventions.

"The hope is that when you have impaired function that there will be changes (in the signals)," Gore said. "We've already got evidence for that from other studies."

Studies of the "resting" brain reveal how neural circuits coordinate to control various functions and to produce different behaviors. The spinal cord has been more difficult to study because it is much smaller than the brain, and conventional fMRI isn't sensitive enough to pick up its signals.

The Vanderbilt team overcame this challenge by using an fMRI scanner with a 7 Tesla magnet, multichannel spinal cord coils, and advanced methods for acquiring and analyzing the images. One Tesla is roughly 20,000 times the strength of the magnetic field of the earth.


Contact: Craig Boerner
Vanderbilt University Medical Center

Related medicine news :

1. Vanderbilt study examines bacterias ability to fight obesity
2. Vanderbilt-led study identifies genes linked to breast cancer in East Asian women
3. Vanderbilt discovery may advance colorectal cancer diagnosis and treatment
4. Vanderbilt study finds women referred for bladder cancer less often than men
5. Vanderbilt study explores genetics behind Alzheimers resiliency
6. Vanderbilt study finds physical signs of depression common among ICU survivors
7. Vanderbilt study: Ancient chemical bond may aid cancer therapy
8. Vanderbilt study finds limited resources for injured surgeons
9. AxoGen, Inc. Receives Grant in Partnership with Vanderbilt University from U.S. Department of Defense
10. Vanderbilt study finds lack of exercise not a factor in health disparities
11. Vanderbilt study finds maternal diet important predictor of severity for infant RSV
Post Your Comments:
(Date:11/24/2015)... ... 24, 2015 , ... Preparing for the LDT Regulation:, CLIA Won’t Satisfy the ... , FDA has long asserted that design and manufacture of Laboratory Developed Tests ... do not meet the device regulations. , Come up short in an inspection and ...
(Date:11/24/2015)... ... November 24, 2015 , ... Brillouin Energy Corp. Congress and ... developer of renewable energy technologies capable of producing commercially useful amounts of thermal ... its WET™ and HHT™ Boiler System reactor core modules were presented to Congress ...
(Date:11/24/2015)... , ... November 24, 2015 , ... ... to share their knowledge and experiences at a live taping of the next ... Center for the Cure of Gastrointestinal Cancers 2015 Symposium at Georgetown University Hotel ...
(Date:11/24/2015)... ... 2015 , ... Serenity Point Rehabilitation, a holistic treatment center for substance abuse ... of the staff members at their recovery center. The videos highlight some of the ... of the things that make their recovery program so unique. , “Making the decision ...
(Date:11/24/2015)... ... ... Shoulder , LLC launched their Pro Vest, the latest version of their widely popular weight ... under 10 hours. , The campaign, which will continue to run through ... market. , The PRO Vest provides consumers with a less expensive, one-size fits all comfort ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... -- Teledyne DALSA , a Teledyne Technologies company and ... its CMOS X-Ray detector for mammography at the ... 3, at McCormick Place in Chicago . ... imaging will be on display in the South Hall, Booth ... X-Ray detectors is the industry benchmark for high speed imaging ...
(Date:11/24/2015)... 24, 2015 The uptake of recently approved and ... key driver of market growth to 2021, says GBI ... pipeline premium products for Type 1 Diabetes Mellitus (T1DM), will be a ... Research . --> The uptake of recently approved ... a key driver of market growth to 2021, says ...
(Date:11/24/2015)... NEWTOWN, Pa. , Nov. 24, 2015  NuShield, Inc., an industry leader in LCD screen ... mobile and stationary computer technology as part of their patient monitoring or electronic documentation system. ... ... ... ...
Breaking Medicine Technology: