Navigation Links
Vanderbilt discovery may advance colorectal cancer diagnosis and treatment
Date:7/22/2014

n the RNA of the samples did not necessarily "translate" into abnormal proteins.

Similarly, some sections of chromosomes that were "amplified" in the tumor samples did not result in amplified or increased protein levels.

Those that did, however, produced "striking effects," suggesting that proteomics might help identify and prioritize the most "impactful" genetic abnormalities that could be targets for new diagnostic tests or drug treatments, Liebler said.

The researchers also identified five subtypes of colon cancer based on their protein content, one of which was associated with poor outcomes. Proteomics thus may help identify patients who would benefit most from chemotherapy after surgery.

"Our discovery of proteomic subtypes opens the door to protein-based diagnostics that could potentially identify the bad cancers that need the aggressive therapy," Liebler said. "That's what we're really hot on going forward."

Liebler said that the support of the Ayers Institute, established in 2005 with a $10 million gift from Jim Ayers, chairman of FirstBank in Lexington, Tenn., and his wife Janet Ayers, was critical for building the infrastructure for conducting the research.

"Without the Ayers Institute, we wouldn't have been in a position to even apply for the CPTAC program, to be a part of this at all," Liebler said.

"This is exciting news that appears to have tremendous implications for cancer diagnosis and treatment," said Janet Ayers. "Jim and I extend our congratulations to Dr. Liebler and the team working with the Jim Ayers Institute for Precancer Detection and Diagnosis at the Vanderbilt-Ingram Cancer Center.

"These are the kinds of discoveries we hoped for when the institute was launched just a few years ago," she said. "To start seeing results like this so quickly is extremely rewarding."


'/>"/>
Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Vanderbilt study finds women referred for bladder cancer less often than men
2. Vanderbilt study explores genetics behind Alzheimers resiliency
3. Vanderbilt study finds physical signs of depression common among ICU survivors
4. Vanderbilt study: Ancient chemical bond may aid cancer therapy
5. Vanderbilt study finds limited resources for injured surgeons
6. AxoGen, Inc. Receives Grant in Partnership with Vanderbilt University from U.S. Department of Defense
7. Vanderbilt study finds lack of exercise not a factor in health disparities
8. Vanderbilt study finds maternal diet important predictor of severity for infant RSV
9. Vanderbilt study reveals clues to childhood respiratory virus
10. Vanderbilt study examines Affordable Care Acts impact on uncompensated care
11. Vanderbilt study finds diverse genetic alterations in triple-negative breast cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... Cancer researchers have just published an important ... deadly malignant pleural mesothelioma. Surviving Mesothelioma has just posted ... Click here to read it now. , Doctors ... and New York’s Langone Medical Center performed complete genetic ... in an effort to pinpoint the genes that are ...
(Date:12/15/2014)... a leading mobile app development company , custom ... which allows users to keep track of wines they ... right wine. At the center of WineMatch is ... wine information. All this information is assembled to help ... are close counterparts to one another are called Matches. ...
(Date:12/15/2014)... (HealthDay News) -- Expert pilots process visual information more ... make better decisions during landings, a new study shows. ... for pilots to master, and 36 percent of all ... during final approach and landing. Researchers monitored the ... experienced pilots while they were at the controls of ...
(Date:12/15/2014)... In support of high-quality independent ... restrictive state laws that may have unintended consequences ... area of public health policy. , The position ... of Independent Review, contends that state legislation that ... review determinations can result in subpar outcomes for ...
(Date:12/15/2014)... (PRWEB) December 15, 2014 For the second ... Coffee Review “Top 30 Coffees of 2014.” Bird Rock Coffee ... their Guji Zone Ethiopia at number 10. This is the ... , Coffee Review’s selection is ranked on quality, value, and ... Batak scored 96 out of 100, and at $17.99 for ...
Breaking Medicine News(10 mins):Health News:New Study Reveals Genetic Mutations That May Trigger Mesothelioma, According to Surviving Mesothelioma 2Health News:Use WinMatch Connect App to Keep Track of Wines You Like 2Health News:Study Shows Why Expert Pilots Are Experts 2Health News:NAIRO Calls for Higher Quality Independent Peer Review By Ending Restrictive State Laws 2Health News:Bird Rock Coffee Roasters Ranks Second and Tenth in Coffee Review’s ‘Top 30 Coffees of 2014’ 2
... Serena Gordon HealthDay Reporter , TUESDAY, March 8 ... an increased risk of dying, even as long as three ... Those who are discharged from the hospital to a skilled ... according to the study. People between 31 and 65 who ...
... -- Treatment for drug addiction is affected by a person,s ... report. A research team at the Brookhaven National Laboratory ... have lower gray matter density -- and therefore fewer neurons ... decision-making, self-control, learning and memory. "This research shows that ...
... many hours we spend in light, dreamless slumber. But a ... busy recharging our brain,s learning capacity during this traditionally undervalued ... UC Berkeley researchers have found compelling evidence that ... networking between key regions of the brain to clear a ...
... Fla. The Pancreatic Cancer Action Network and the ... Bailey, Ph.D., and E. Scott Seeley, M.D., Ph.D., the ... Leadership Grants. These grants, each totaling $600,000 over five ... Annual Meeting 2011, held April 2-6. "Because of ...
... A prolific University of Missouri chemist has discovered ... make certain drugs. Jerry Atwood, Curator,s Professor and ... College of Arts and Science, has recently published a ... that states that highly pressurized carbon dioxide at room ...
... VA The National Comprehensive Cancer Network (NCCN), and ... announce a collaboration to advance research for cancer imaging ... qualify imaging sites for upcoming research projects utilizing molecular ... Research Program (ORP), obtains funding to support scientifically meritorious ...
Cached Medicine News:Health News:Risk of Death May Linger for Trauma Survivors 2Health News:Risk of Death May Linger for Trauma Survivors 3Health News:Genes May Affect Severity of Drug Addiction 2Health News:As we sleep, speedy brain waves boost our ability to learn 2Health News:As we sleep, speedy brain waves boost our ability to learn 3Health News:PanCan-AACR Pathway to Leadership grants awarded 2Health News:PanCan-AACR Pathway to Leadership grants awarded 3Health News:PanCan-AACR Pathway to Leadership grants awarded 4Health News:MU chemist discovers shortcut for processing drugs 2Health News:National Comprehensive Cancer Network and SNM join to advance oncology imaging research 2
(Date:12/17/2014)... 2014  Northstar Global Business Services, Inc. (OTCPink:MDIN) ... has made their final decision and has determined ... stock effective December 15, 2014, and has resumed ... and book entry transfer services. All deposit restrictions have ... again fully "DTC Eligible", and has resumed electronic ...
(Date:12/17/2014)...  IGI Laboratories, Inc. (NYSE MKT: IG; "IGI" or ... of $125 million aggregate principal amount of 3.75% Convertible ... offered and sold only to qualified institutional buyers pursuant ... as amended (the "Securities Act"). The Notes ... year, payable semiannually in arrears on June 15 and ...
(Date:12/15/2014)... 2014 Research and Markets ( ... "MEMS Gyroscopes Analog Devices ADIS16136 Precision Angular ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... applications made a lot of progress in the ... are now accepted in high-reliability environments, and are ...
Breaking Medicine Technology:Northstar announces that the DTC chill on MDIN has been officially lifted 2Northstar announces that the DTC chill on MDIN has been officially lifted 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 2IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 4MEMS Gyroscopes Analog Devices ADIS16136 Precision Angular Rate Sensor Reverse Costing Analysis 2
... , March 15 /PRNewswire-Asia-FirstCall/ -- Renhuang,Pharmaceuticals, Inc. ... and distributor of botanical products,bio-pharmaceuticals and traditional Chinese medicines ... a conference call at 10:00 a.m. Eastern Time ... financial results for the first quarter,of its fiscal year ...
... announced today that it has finalized an amendment to its loan and security agreement with Silicon Valley Bank.  The amendment extends the ... to obtain additional funds if necessary. , ... , ... ...
Cached Medicine Technology:Renhuang Schedules Conference Call to Discuss FY 2010 First Quarter Results 2Renhuang Schedules Conference Call to Discuss FY 2010 First Quarter Results 3Otix Global, Inc. Extends Term of Loan and Security Agreement With Silicon Valley Bank 2Otix Global, Inc. Extends Term of Loan and Security Agreement With Silicon Valley Bank 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: