Navigation Links
Vanda Pharmaceuticals' VSF-173 Excessive Sleepiness Phase II Clinical Trial Suggests Wake-Promoting Properties
Date:10/30/2007

ROCKVILLE, Md., Oct. 30 /PRNewswire-FirstCall/ -- Vanda Pharmaceuticals Inc. (Nasdaq: VNDA), a biopharmaceutical company focused on the development and commercialization of clinical-stage product candidates for central nervous system disorders, today announced top-line results from the Company's Proof- of-Concept Phase II clinical trial evaluating VSF-173 in a clinical model of excessive sleepiness.

This Phase II study examined the effects of VSF-173 on a model of excessive sleepiness among 55 healthy volunteers treated with 3 doses of VSF-173 administered at 50 mg, 100 mg and 200 mg and placebo administered at 25 mg, 50 mg and 100 mg at the usual bedtime and at four hours after the first dose. In this model, the effect of the compound was evaluated with a series of six Maintenance of Wakefulness Tests (MWT) given two hours apart starting one hour after the first dose. The effect of the drug was also evaluated on the scheduled daytime recovery sleep following the night time and morning evaluations.

On the primary endpoint which evaluated the effect of the compound on the first four series of MWT tests, VSF-173 demonstrated improvements over placebo. The mean MWT sleep onset scores for the 50 mg, 100 mg and 200 mg, and placebo groups were 10.3, 12.9, 10.6 and 9.2 minutes, respectively. While the pair-wise analysis did not reach statistical significance, this magnitude of effect, ranging from 1.1 to 3.7 minutes, is generally similar to that observed with modafinil in the treatment of patients with narcolepsy.

In a subset of 37 subjects with no observed impairment in pre-dose daytime wakefulness (MWT cutoff equal to 30 minutes), the mean of all six MWT scores for the 50 mg, 100 mg and 200 mg groups show
'/>"/>

SOURCE Vanda Pharmaceuticals Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Supply of Radiopharmaceuticals Hampered by Attacks
2. FDA approves Watson Pharmaceuticals Oxytrol patch
3. Ranbaxy Pharmaceuticals Inc awarded the prestigious outstanding supplier award received from Wal-Mart
4. Antigenics Pharmaceuticals plans for Phase III trial of its Melanoma vaccine
5. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals
6. Top Pharmaceuticals Influence Doctors Prescriptions
7. More Study On Side Effects of ADHD Drug Needed: Shire Pharmaceuticals
8. Personalized Medicine and Innovative Pharmaceuticals
9. New lease of life for asthmatics by Accentia Biopharmaceuticals
10. Pravastatin Launched by Watson Pharmaceuticals
11. Tata Industries picks up stake in Indigene Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... Genetics identifies a novel genetic and molecular ... (EoE), opening up potential new therapeutic strategies for ... EoE is a chronic inflammatory disorder of the ... to certain foods and an over-accumulation in the ... of the body,s immune system). EoE can cause ...
(Date:7/13/2014)... (PRWEB) July 13, 2014 Recently, MillionaireCasket.com, a ... of oak caskets . Additionally, the company’s chief executive ... All the new oak caskets are offered at discounted prices, ... I am concerned, quality caskets are in huge demand in ... oak caskets . We have a lot of high ...
(Date:7/13/2014)... Micro irrigation systems are mainly utilized for agriculture ... as to maintain soil quality. The application of micro ... dominant revenue generator for manufacturers in future. The trend ... has led to the adoption of micro irrigation techniques ... massive demand for micro irrigation systems, as they reduce ...
(Date:7/13/2014)... 2014 Fuel additives are chemicals, which ... jet fuel, kerosene, and so on, in order to ... reducing the corrosion effects caused by fuels and improving ... any fuel, provide economies of scale in the long ... overall cost of the fuel products. , The various ...
(Date:7/13/2014)... (PRWEB) July 13, 2014 A Massachusetts ... to the cancer risks associated with power morcellators ( ... their story to federal regulators, as they presented poignant ... Food & Drug Administration (FDA) advisory panel meeting convened ... According to the Rochester Democrat and Chronicle, Dr. Hooman ...
Breaking Medicine News(10 mins):Health News:Study finds cause of mysterious food allergy, suggests new treatment strategy 2Health News:Study finds cause of mysterious food allergy, suggests new treatment strategy 3Health News:Cheap Oak Caskets Recently Unveiled By China Casket Manufacturer MillionaireCasket.com 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 4Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 2Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 3Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 4
... , , , , LOS ... Christmas " presentation is being telecast over multiple broadcasts, cable ... million homes this year. Participating stars and other notables include ... Nicole Kidman, Bob Costas, and Natalie Cole. , (Photo: ...
... , CLASS Act Long-Term Care Provision Key to Reform ... the National Council on Aging: , WASHINGTON, Dec. 23 The ... and Affordable Care Act (H.R. 3590), which, when passed, will bring ... care that is both accessible and affordable for Americans of all ...
... Inhibition of transcription factor E2F1 reduced epidermal growth factor ... not proliferation of metastatic melanoma cells, according to a ... Journal of the National Cancer Institute . To ... M.D., Ph.D., of the department of vectorology and experimental ...
... say, , WEDNESDAY, Dec. 23 (HealthDay News) -- A ... can have a dark side, with asymptomatic children passing ... get colonized by strep and pneumococcus, and they are ... it, but the elderly are more susceptible to it," ...
... , , LOS ANGELES, Dec. 23 ... risky behavior on the lighter side and a total depletion of honesty ... a lack of production at work and even murder, those who fall ... the declining moral fabric of our society. , Narconon is considered by ...
... detailed search of breast cancer genomes to uncover genomic ... in which the human genome is broken and put ... Rearrangements involve reshuffling and reorganisation of the genome ... sequences. The study shows that breast cancer samples can ...
Cached Medicine News:Health News:Top Stars Rally for Fighting Blindness, Sending Their Message out to 160 Million Homes on Multiple Cable Networks, December 25th, Preceded by President George Herbert Walker Bush Describing the Frank Capra Classic, 'It's A Wonderful Life' for the Bl 2Health News:NCOA Supports Senate Health Reform Bill 2Health News:NCOA Supports Senate Health Reform Bill 3Health News:Kids Can Pass Pneumonia Bug to Older Relatives During Holidays 2Health News:Narconon Helps Restore Honesty and Trust to Former Addicts 2Health News:Narconon Helps Restore Honesty and Trust to Former Addicts 3Health News:Broken genomes behind breast cancers 2Health News:Broken genomes behind breast cancers 3
(Date:7/10/2014)... July 10, 2014   Ventana Medical Systems, Inc. ... it has entered into an agreement with Merck KGaA, ... EMD Serono in the United States ... with Merck KGaA,s biopharmaceutical division on the development and ... target using Ventana,s proprietary diagnostic assays. In alignment with ...
(Date:7/10/2014)... Decision Resources Group finds that over half ... and Drug Administration,s (FDA) approval of Vifor Fresenius Medical ... approved by the FDA in November 2013 for the ... on dialysis. Other key findings from the ... : , Bundling: ...
(Date:1/15/2014)... Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced the addition of ... Size, Share, Growth, Trends And Forecast, 2013 - 2018" ... http://photos.prnewswire.com/prnh/20130307/600769 ) Dental consumables ... to treat dental impairments, for tooth restoration and in ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3
... Feb. 8, 2011 The District of Columbia Patients Cooperative ... to provide high quality and affordable medical "marijuana" to qualifying ... implementation of DC,s new medical marijuana program.  The public meeting ... place on Thursday, February 10th at 7:00 pm in Pierce ...
... TUCSON, Ariz., Feb. 8, 2011 MRI Medical Inc. ... as part of its corporate development plan. ... provide our customers with the same superior design, development, ... years," stated Joseph Lee, Xeridiem Medical Devices, Inc.,s President. "Our ...
Cached Medicine Technology:February 10 Town Hall Meeting to Explain DC's New Medical Marijuana Program 2MRI Medical Inc. Changing Name to Xeridiem Medical Devices, Inc. 2
... instrument and custom filter wheels with ... The standard filter set includes: FAM/SYBR ... Red (585nm-610nm), Cy5 (635nm-665nm) and Cy3 ... analysis software, Beacon Designer oligo software, ...
... rapid, real-time thermal cycler used for identifying ... much of the testing process, and making ... the fastest, easiest to use, and most ... SmartCycler delivers highly accurate and consistent test ...
... SmartCycler System is a rapid, real-time thermal ... biological samples. By automating much of the ... individually programmable, it is the fastest, easiest ... on the market. The SmartCycler delivers highly ...
... The Applied Biosystems 7300 Real-Time ... real-time PCR capabilities with exceptional budget ... you to perform gene expression analysis, ... assays with internal positive controls ...
Medicine Products: