Navigation Links
Vancouver researchers discover missing link between TB bacteria and humans
Date:5/14/2008

Researchers at the University of British Columbia and Vancouver Coastal Health Research Institute have discovered how tuberculosis (TB) bacteria hide and multiply in the human body and are working toward a treatment to block this mechanism of infection.

This discovery, published today in the journal Cell Host and Microbe, describes the missing link between a TB protein and its newly discovered counterpart protein in the human bodys white blood cells (macrophages).

TB causes disease by infecting the bodys macrophages. Normally, macrophages engulf bacteria and then release powerful digestive enzymes that destroy the bacteria. The researchers found that a protein secreted by TB targets a protein in the macrophage. In doing so, TB disrupts this process, allowing it to hide and multiply within the macrophage.

The research, lead by Dr. Yossi Av-Gay, research scientist with the Immunity and Infection Research Centre at the Vancouver Coastal Research Institute and associate professor with UBCs Faculty of Medicine, suggests that therapies that block the activity of the TB protein in macrophages would allow the body to identify TB bacteria more easily. This would prevent the establishment of active and latent tuberculosis and will lead to a new and more effective treatment for TB.

Once inside the human macrophage, TB acts as a Trojan Horse, says Dr. Horacio Bach, the primary author of the paper and research scientist with the Immunity and Infection Research Centre at the Vancouver Coastal Research Institute. TB multiplies inside the macrophage and when released attack the human body. By identifying this protein we are now able to expose the hiding bacteria, which will allow the macrophages to destroy them.

The Av-Gay lab has already taken the next step.

Excitingly, we have also been able to engineer a specific antibody that blocks this newly discovered TB protein, says Av-Gay. We are now looking to collaborate with the pharmaceutical industry to come up with a therapy that can be used to block this particular mechanism, which will be an important tool in weakening TB.

TB is called the ultimate killer. It is the leading cause of death among infectious diseases in the world today and is responsible for one in four adult preventable deaths, according to the World Health Organization (WHO). Ten million new cases of TB arise every year, killing close to two million people worldwide annually. Every 20 seconds TB kills someone and approximately 4,400 people die every day. The WHO estimates that one-third of the worlds population is infected. The current treatment regime involves taking multiple medications over an extended period of time.


'/>"/>

Contact: Catherine Loiacono
catherine.loiacono@ubc.ca
604-822-2644
University of British Columbia
Source:Eurekalert

Related medicine news :

1. 1 of the best researchers in general practice
2. Researchers fine-tune clot-busting treatment for bleeding in brain
3. OHSU Cancer Institute researchers pinpoint how smoking causes cancer
4. Yerkes researchers find link between psychological stress and overeating
5. Researchers who helped millions with arthritis receive prestigious Janssen Award
6. Carnegie Mellon engineering researchers automate analysis of protein patterns
7. Health researchers in McGill network receive $35.5 million in CIHR funding
8. Hopkins researchers discover new link to schizophrenia
9. Researchers find gene location that gives rise to neuroblastoma, an aggressive childhood cancer
10. Researchers Find Gene Location That Gives Rise to Neuroblastoma, an Aggressive Childhood Cancer
11. Researchers Publish Genome Sequence for Duck-Billed Platypus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2017)... ... 21, 2017 , ... Phytocéane invites you to take an exotic ... the world with ZANZIBAR SHOWER GEL. Inspired by the beauty of Zanzibar, a Tanzanian ... and moisturizing vegetal coral to create this gentle, crystal-clear shower gel to cleanse the ...
(Date:1/21/2017)... , ... January 21, 2017 , ... ... Austin, Texas Periodontist Dr. Dan Holtzclaw in media for its creos™ line of ... surgeries performed by Dr. Holtzclaw in which he utilizes creos™ allo.gain™ bone graft ...
(Date:1/20/2017)... ... , ... Doctor C LLC, a company based out of Arizona that focuses ... the marketing and distribution of its product, The Right C. , The Right C ... than traditional vitamin C supplements. At the trade show, Doctor C had the opportunity ...
(Date:1/20/2017)... ... January 20, 2017 , ... Michael and Betsy Brauser ... Cancer Institute. For Betsy, the clinical trial has been life-saving as she has ... worsened. , Betsy Brauser was diagnosed with ovarian cancer in 2009. She underwent ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Code Word: Chocolate Biscuit”: a biographical account following a man who ... the creation of published author, Marlyn Ivey, born in Lynn Haven, Florida and at the ... and at 19 years of age, he joined the Navy and got married right out ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... India , January 20, 2017 According ... Type (Descriptive, Prescriptive), Application (Marketing, R&D, Compliance, SCM), Component (Software, Service), ... - Forecasts to 2021" published by MarketsandMarkets, the market is expected ... in 2016, at a CAGR of 13.3% during the forecast period. ... ...
(Date:1/21/2017)... Research and Markets has announced the addition of the ... Of Administration, End User - Forecast to 2025" report to ... The ... CAGR of around 7.8% over the next decade to reach approximately ... the global markets for Advanced Drug Delivery across all the given ...
(Date:1/20/2017)... 2017 Research and Markets has announced ... Devices, Implant Types, OTC Amplifiers, Diagnostic Instruments), Sales Volume, Company ... ... Hearing Aids Market Sales Volume, Company Analysis and Forecast to ... aid industry. The growing prevalence of hearing impairment ...
Breaking Medicine Technology: