Navigation Links
Vancouver researchers discover missing link between TB bacteria and humans
Date:5/14/2008

Researchers at the University of British Columbia and Vancouver Coastal Health Research Institute have discovered how tuberculosis (TB) bacteria hide and multiply in the human body and are working toward a treatment to block this mechanism of infection.

This discovery, published today in the journal Cell Host and Microbe, describes the missing link between a TB protein and its newly discovered counterpart protein in the human bodys white blood cells (macrophages).

TB causes disease by infecting the bodys macrophages. Normally, macrophages engulf bacteria and then release powerful digestive enzymes that destroy the bacteria. The researchers found that a protein secreted by TB targets a protein in the macrophage. In doing so, TB disrupts this process, allowing it to hide and multiply within the macrophage.

The research, lead by Dr. Yossi Av-Gay, research scientist with the Immunity and Infection Research Centre at the Vancouver Coastal Research Institute and associate professor with UBCs Faculty of Medicine, suggests that therapies that block the activity of the TB protein in macrophages would allow the body to identify TB bacteria more easily. This would prevent the establishment of active and latent tuberculosis and will lead to a new and more effective treatment for TB.

Once inside the human macrophage, TB acts as a Trojan Horse, says Dr. Horacio Bach, the primary author of the paper and research scientist with the Immunity and Infection Research Centre at the Vancouver Coastal Research Institute. TB multiplies inside the macrophage and when released attack the human body. By identifying this protein we are now able to expose the hiding bacteria, which will allow the macrophages to destroy them.

The Av-Gay lab has already taken the next step.

Excitingly, we have also been able to engineer a specific antibody that blocks this newly discovered TB protein, says Av-Gay. We are now looking to collaborate wi
'/>"/>

Contact: Catherine Loiacono
catherine.loiacono@ubc.ca
604-822-2644
University of British Columbia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. 1 of the best researchers in general practice
2. Researchers fine-tune clot-busting treatment for bleeding in brain
3. OHSU Cancer Institute researchers pinpoint how smoking causes cancer
4. Yerkes researchers find link between psychological stress and overeating
5. Researchers who helped millions with arthritis receive prestigious Janssen Award
6. Carnegie Mellon engineering researchers automate analysis of protein patterns
7. Health researchers in McGill network receive $35.5 million in CIHR funding
8. Hopkins researchers discover new link to schizophrenia
9. Researchers find gene location that gives rise to neuroblastoma, an aggressive childhood cancer
10. Researchers Find Gene Location That Gives Rise to Neuroblastoma, an Aggressive Childhood Cancer
11. Researchers Publish Genome Sequence for Duck-Billed Platypus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... ... September 02, 2015 , ... On ... Officers Association of America (MOAA) and Wounded Warrior Project® (WWP), will be ... Own,” expert panelists will lead interactive discussions on the responsibilities and commitments ...
(Date:9/2/2015)... ... , ... Telehealth represents a growing trend among Blue Cross and Blue Shield ... more than 12 Blues plan clients. The September 2015 issue of The ... trend, interviewing executives at Capital Blue Cross, whose telehealth services will launch next year. ...
(Date:9/2/2015)... (PRWEB) , ... September 02, 2015 , ... In “Failure ... by the Huffington Post on August 25th, writer Akela Stanfield detailed her lifelong struggle ... the author acknowledged that she had always seen herself as someone who would lose ...
(Date:9/2/2015)... ... 02, 2015 , ... Splashtop Inc., the worldwide leader in ... mirroring and extending product line -- Splashtop Wired XDisplay . Complementing ... setting, the new Splashtop Wired XDisplay delivers enhanced performance and reliability for users ...
(Date:9/2/2015)... ... ... Good health and a good cause paired up at The Barclays this past ... to the New Jersey Golf Foundation through its Healthy Steps Challenge. After making ... BCBSNJ challenged PGA TOUR golfer and NJ native Morgan Hoffmann to add more by ...
Breaking Medicine News(10 mins):Health News:MOAA and WWP host 2015 Warrior-Family Symposium Chairman of the Senate Committee on Veterans' Affairs and the Secretary of Veterans Affairs to Speak 2Health News:MOAA and WWP host 2015 Warrior-Family Symposium Chairman of the Senate Committee on Veterans' Affairs and the Secretary of Veterans Affairs to Speak 3Health News:AIS Newsletter Focuses on Growing Telehealth Trend Among Blues Plans 2Health News:AIS Newsletter Focuses on Growing Telehealth Trend Among Blues Plans 3Health News:Recent Editorial on Bariatric Surgery Acceptance Illuminates a Typical Journey Towards Weight Loss Surgery, Notes Dr. Michael Feiz 2Health News:Splashtop Launches Wired XDisplay, the Fastest Screen Sharing Solution for Extending and Mirroring Your Computer Screen to Mobile Devices 2Health News:Splashtop Launches Wired XDisplay, the Fastest Screen Sharing Solution for Extending and Mirroring Your Computer Screen to Mobile Devices 3Health News:Horizon BCBSNJ’s Healthy Steps Challenge Raises an Additional $6,000 for the NJ Golf Foundation with Help from PGA TOUR Golfer Morgan Hoffmann 2Health News:Horizon BCBSNJ’s Healthy Steps Challenge Raises an Additional $6,000 for the NJ Golf Foundation with Help from PGA TOUR Golfer Morgan Hoffmann 3
... to warn Indonesians about bird flu will commence next week,. ... of 49 people in the country which ranks as ... to John Budd, head of communications with the United Nations ... several members of socio- religious groups will be involved in ...
... and vitamin D supplements is apparently of no use in ... //from the Women's Health Initiative study. Previous research had suggested ... risk. ,'We can't yet make a general recommendation ... each day as supplements,' said Dr. Rowan Chlebowski, the study's ...
... 200 elderly people in the Argyll and Bute Council area ... it has emerged//. Labour MSP Jackie Baillie said that the ... investigate. ,Argyll and Bute Council said it had ... that there were about 200 eligible people not receiving care, ...
... major Ranbaxy Laboratories Ltd today said its wholly owned ... //with Hyderabad-based Zenotech Laboratories Ltd to market generic cancer ... the agreement, Zenotech Labs would develop, submit for regulatory ... Ranbaxy would market these products as generic formulations in ...
... Togadiya, who underwent an angioplasty at a private hospital here, ... ,Togadiya was admitted to SAL hospital here yesterday, ... Bhupesh Shah carried out the angioplasty on Togadiya last night., ... of the leader is stable and he is expected to ...
... beer while watching the World Cup on television may be ... the game, says a new study. // ,Psychology ... are not confident of their sporting abilities are likely to ... ,The study, based on interviews with 31 London youths in ...
Cached Medicine News:
(Date:9/2/2015)... NEW YORK , Sept. 2, 2015   ... of the most common laboratory technologies that is used ... and antibodies in solution. ELISA test uses various types ... alkaline phosphatases and the result is detected by photometry ... in the treatment of various infectious diseases such as ...
(Date:9/2/2015)... Sept. 2, 2015 Transaction ... base with highly profitable specialty products , ... growth potential with 11 product applications pending at ... certifications  , Provides medium and longer term ... including eight controlled substances , Adds development ...
(Date:9/2/2015)... , Sept. 2, 2015   Physicians Rx Pharmacy ... has joined the organization as President and Chief ... served as President and Chief Executive Officer for Soleo ... Executive Officer of Physicians Rx Pharmacy, be responsible for ... "We are extremely pleased to bring Gaston on as ...
Breaking Medicine Technology:Global Enzyme-Linked Immunosorbent Assay (Elisa) Testing Market 2015-2019 2Global Enzyme-Linked Immunosorbent Assay (Elisa) Testing Market 2015-2019 3Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 2Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 3Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 4Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 5Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 6Gaston L. Bernstein Named President and CEO of Physicians Rx Pharmacy 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: