Navigation Links
Vancouver researchers discover missing link between TB bacteria and humans
Date:5/14/2008

Researchers at the University of British Columbia and Vancouver Coastal Health Research Institute have discovered how tuberculosis (TB) bacteria hide and multiply in the human body and are working toward a treatment to block this mechanism of infection.

This discovery, published today in the journal Cell Host and Microbe, describes the missing link between a TB protein and its newly discovered counterpart protein in the human bodys white blood cells (macrophages).

TB causes disease by infecting the bodys macrophages. Normally, macrophages engulf bacteria and then release powerful digestive enzymes that destroy the bacteria. The researchers found that a protein secreted by TB targets a protein in the macrophage. In doing so, TB disrupts this process, allowing it to hide and multiply within the macrophage.

The research, lead by Dr. Yossi Av-Gay, research scientist with the Immunity and Infection Research Centre at the Vancouver Coastal Research Institute and associate professor with UBCs Faculty of Medicine, suggests that therapies that block the activity of the TB protein in macrophages would allow the body to identify TB bacteria more easily. This would prevent the establishment of active and latent tuberculosis and will lead to a new and more effective treatment for TB.

Once inside the human macrophage, TB acts as a Trojan Horse, says Dr. Horacio Bach, the primary author of the paper and research scientist with the Immunity and Infection Research Centre at the Vancouver Coastal Research Institute. TB multiplies inside the macrophage and when released attack the human body. By identifying this protein we are now able to expose the hiding bacteria, which will allow the macrophages to destroy them.

The Av-Gay lab has already taken the next step.

Excitingly, we have also been able to engineer a specific antibody that blocks this newly discovered TB protein, says Av-Gay. We are now looking to collaborate with the pharmaceutical industry to come up with a therapy that can be used to block this particular mechanism, which will be an important tool in weakening TB.

TB is called the ultimate killer. It is the leading cause of death among infectious diseases in the world today and is responsible for one in four adult preventable deaths, according to the World Health Organization (WHO). Ten million new cases of TB arise every year, killing close to two million people worldwide annually. Every 20 seconds TB kills someone and approximately 4,400 people die every day. The WHO estimates that one-third of the worlds population is infected. The current treatment regime involves taking multiple medications over an extended period of time.


'/>"/>

Contact: Catherine Loiacono
catherine.loiacono@ubc.ca
604-822-2644
University of British Columbia
Source:Eurekalert

Related medicine news :

1. 1 of the best researchers in general practice
2. Researchers fine-tune clot-busting treatment for bleeding in brain
3. OHSU Cancer Institute researchers pinpoint how smoking causes cancer
4. Yerkes researchers find link between psychological stress and overeating
5. Researchers who helped millions with arthritis receive prestigious Janssen Award
6. Carnegie Mellon engineering researchers automate analysis of protein patterns
7. Health researchers in McGill network receive $35.5 million in CIHR funding
8. Hopkins researchers discover new link to schizophrenia
9. Researchers find gene location that gives rise to neuroblastoma, an aggressive childhood cancer
10. Researchers Find Gene Location That Gives Rise to Neuroblastoma, an Aggressive Childhood Cancer
11. Researchers Publish Genome Sequence for Duck-Billed Platypus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob ... sciatica in a new episode of "Success Files," which is an award-winning educational ... and investigates each subject in-depth with passion and integrity. , Sciatica occurs when ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and ... of published author, William Nowers. Captain Nowers and his wife, Millie, have six ... years in the Navy. Following his career as a naval aviator and carrier ...
(Date:10/12/2017)... ... , ... Planet Fitness, one of the largest and fastest growing franchisors and ... flagship location in Covington, LA at 401 N. U.S. Highway 190, in January of ... Depot in the Holiday Square shopping center. Its location allows it to serve both ...
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris ... of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking ... in the field of medical informatics, this prestigious award is presented to an individual ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, the ... medical article to the newly revamped Cosmetic Town journal section, featuring ... transplant procedure known as Follicular Unit Extraction (FUE). , Dr. Mohebi ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... Ill. , Oct. 5, 2017  In ... Association of Oral and Maxillofacial Surgeons (AAOMS) released ... opioids – to be used as a first-line ... pain. Recognizing ... the AAOMS White Paper "Opioid Prescribing: Acute and ...
(Date:10/4/2017)... Mass. , Oct. 4, 2017 ... of single-use, self-contained, illuminating medical devices, today announced ... National Health Surveillance Agency (or Agência Nacional de ... The first single-use, cordless surgical retractor with integrated ... provides optimal access, illumination and exposure of a ...
(Date:10/2/2017)... , Oct. 2, 2017  AllianceRx Walgreens Prime, the ... by Walgreens and pharmacy benefit manager Prime Therapeutics LLC ... brand, which included the unveiling of new signage at ... as well as at a few other company-owned facilities ... brand to patients, some of whom will begin to ...
Breaking Medicine Technology: