Navigation Links
Van Andel Research Institute findings provide more complete picture of kidney cancer
Date:12/29/2011

Grand Rapids, Mich. (December 29, 2011) Two recent studies by Van Andel Research Institute scientists are providing a foundation for a more complete understanding of distinct kidney cancer subtypes, which could pave the way for better treatments.

In a study published in Cancer Cell led by Kyle Furge, Ph.D. and Aikseng Ooi, Ph.D., researchers provide a more complete understanding of the biology of Type 2 papillary renal cell carcinoma (PRCC2), an aggressive type of kidney cancer with no effective treatment, which lays the foundation for the development of effective treatment strategies.

Despite obvious morphological, genetic, and clinical differences, hereditary PRCC2 is thought to share similar pathway deregulation due to genetic mutation with its counterpart, clear cell renal cell carcinoma (CCRCC), a subtype that accounts for 75% of all kidney cancers and that, unlike PRCC2, responds favorably to drugs targeting vascular endothelial growth factor (VEGF), a signal protein produced by cells that stimulate blood vessel formation.

The study, which included international collaboration with researchers from the National Cancer Centre Singapore, Gntique Oncologique EPFE-INSERM U753 and Facult de Mdecine Paris-Sud, Le Kremlin-Bictre and Institut de Cancrologie Gustave Roussy, Michigan State University, Northwestern Memorial Hospital, Cleveland Clinic, Singapore General Hospital, and The Wistar Institute, identified deregulation of the KEAP1-NRF2 signaling pathway as a factor that distinguishes PRCC2 from CCRCC, but links both hereditary and sporadic PRCC2.

In another study published in Cancer Research, led by Yan Ding, Ph.D., and Bin Tean Teh, Ph.D. and carried out in collaboration with the National Cancer Centre Singapore, researchers integrated gene expression profiling and RNAi screening data to identify genes involved in CCRCC development and progression.

In recent years, several molecularly targeted therapi
'/>"/>

Contact: Joe Gavan
joe.gavan@vai.org
616-234-5390
Van Andel Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Van Andel Institute study may lead to better, safer drug for diabetes
2. Van Andel Research Institute finding could lead to reduced side effects in anti-cancer antibiotics
3. Van Andel Research Institute finding is potential predictor of deadly cancer common in Asia
4. Chairman Al Brandel of Lions Clubs International Foundation to Appear in Washington DC's National Memorial Day Parade
5. AADR awards the 2010 Distinguished Mentoring Award to Irwin D. Mandel
6. Research!America Chair John Edward Porter says health research and prevention fared well in 2011
7. UT Southwestern research suggests new way to ensure effectiveness of TB treatment
8. President Obama and leading GOP presidential candidate support health research
9. Cleveland Clinic researchers honored for contributions to science
10. UK researchers present findings from Kentucky breast cancer patients with disease relapse
11. Pitt researchers propose new model to design better flu shots
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2015)... The decision to relocate US Sports Football Camps ... make camp more accessible to campers outside of the region. ... Camp. The fields are in premier condition and the dorms ... de Surville, vice president of US Sports Camps. “In addition ... with the passion to create a program that makes a ...
(Date:2/27/2015)... Everett, WA (PRWEB) February 27, 2015 With ... homeowners to keep the condition of their crawl spaces in ... a few of the most common FAQs regarding crawl space ... by giving an answer to owners that are confused as ... article says that, “One of the most common ways is ...
(Date:2/27/2015)... 27, 2015 Prescription Drug “Take-Back” ... Drug Enforcement Agency (DEA). Today, local ... to utilize the “Take-Back” guidelines for the proper ... , Eufaula Prescription Drug Disposal Event , The ... in Eufaula, Oklahoma as the “Take-Back” site for ...
(Date:2/27/2015)... According to a Feb. 12, 2015 news release by ... cancer by killing cancer stem cells, has received orphan drug ... use in the treatment of mesothelioma.* According to the release, ... the development of drugs for the treatment of rare diseases. ... said Melinda Helbock, Founder of The Law Office of Melinda ...
(Date:2/27/2015)... 2015 The report analyzes the primary ... global celiac disease market. It also assesses key players ... activities, and investments. , Celiac disease is an autoimmune ... small intestine. Celiac disease often has a genetic predisposition. ... is affected by celiac disease across the globe. When ...
Breaking Medicine News(10 mins):Health News:US Sports Camps Football Camps Announce New Contact Football Camp Northeast Location 2Health News:Crawl Space FAQs are Answered in Clean Crawls Latest Article 2Health News:Narconon Arrowhead Promotes Local Prescription Drug Take Back Day 2Health News:Narconon Arrowhead Promotes Local Prescription Drug Take Back Day 3Health News:New Drug Receives FDA Approval as Orphan Drug for the Treatment of Mesothelioma 2Health News:New Drug Receives FDA Approval as Orphan Drug for the Treatment of Mesothelioma 3Health News:Global Celiac Disease Market Counts on Drug Launch for Growth 2Health News:Global Celiac Disease Market Counts on Drug Launch for Growth 3
... Focus is system that regulates blood pressure and fluid ... News) -- New research is shedding some light on ... cause miscarriage and death in pregnant women. , "Preeclampsia ... 10 percent of all pregnancies in the United States," ...
... (FA) is a rare and dangerous disease, new laboratory research ... shows it may lead researchers toward clues in more common ... a study published in the Sept. 11 issue of the ... proteins to DNA damage sites is controlled by replication in ...
... the biggest student drinking problems have so far failed to turn ... in the September issue of the Journal of Studies on ... students, alcohol habits showed little change over a dozen years. In ... two weeks; in 2005, 56 percent said the same. And although ...
... blind and visually impaired often rely on others to provide ... with this method is that it doesn,t give them the ... Lahav of Tel Aviv University,s School of Education and Porter ... to the blind, Dr. Lahav has invented a new software ...
... Administration,s (FDA) recent decision to approve the radioimmunotherapy (RIT) ... lymphoma (NHL). "This is welcome news for ... Ph.D., president of SNM and director of nuclear medicine ... "We,ve known for some time that RIT works extremely ...
... Television journalist Veronica ... and now directs her brother,s story to the White House , ... Los Angeles, CA (PRWeb) September 10, 2009 -- After ... brought the tale of her brother Eric,s tragic battle against health care red tape to ...
Cached Medicine News:Health News:Research Seeks Cause of Preeclampsia 2Health News:Replication at DNA damage sites highlights Fanconi anemia and breast cancer proteins 2Health News:Heavy-drinking colleges showing no improvements 2Health News:Virtual maps for the blind 2Health News:Virtual maps for the blind 3Health News:SNM applauds FDA's decision to approve Zevalin 2Health News:Television Journalist Veronica De La Cruz Brings Her Brother's Story from L.A. to White House in Fight for Health Care Reform 2Health News:Television Journalist Veronica De La Cruz Brings Her Brother's Story from L.A. to White House in Fight for Health Care Reform 3
(Date:2/26/2015)... 2015  BD Life Sciences, a segment of ... BDX ), a leading global medical technology company, ... enabling high-resolution biology, today announced that they will ... multiplexed cell isolation and single-cell gene expression analysis. ... BD FACS™ single-cell sorting instrumentation and software with ...
(Date:2/26/2015)... , Feb. 26, 2015  Spring Bank ... therapeutics for the treatment of virus infections, today ... has been appointed Vice President of Finance, a ... for financial and administrative activities, including financial planning ... to Douglas J. Jensen , President and ...
(Date:2/26/2015)... 26, 2015 Integrity Applications, Inc. (OTCQB: IGAP) ... model DF-F, a noninvasive  device that tracks blood glucose ... Ph.D., will head its new scientific advisory board that ... field of Diabetes research, monitoring and treatment. ... Chief Executive Officer and Head, Business Development of Profil ...
Breaking Medicine Technology:BD and Cellular Research Announce Co-marketing Efforts for Single-Cell Sequencing 2BD and Cellular Research Announce Co-marketing Efforts for Single-Cell Sequencing 3Jonathan P. Freve, CPA, Joins Spring Bank Pharmaceuticals as Vice President of Finance 2Integrity Applications Names Prof. Lutz Heinemann to Advisory Board 2Integrity Applications Names Prof. Lutz Heinemann to Advisory Board 3Integrity Applications Names Prof. Lutz Heinemann to Advisory Board 4
... Md., Nov. 9, 2010 The U.S. Food and ... computed tomography (CT) brain perfusion scans were accidently exposed ... used, the CT scanners did not malfunction. Instead, it ... resulted in these overdoses. However, the FDA has identified ...
... Colo., Nov. 9, 2010 Baxa Corporation , ... automate pharmacy operations, today introduced the ExactaMix 1200 ... hospital pharmacies in need of an automated approach to ... the market-proven Baxa ExactaMix Product Line and brings delivery ...
Cached Medicine Technology:FDA Working to Prevent Radiation Overdoses During CT Scans 2FDA Working to Prevent Radiation Overdoses During CT Scans 3Baxa Corporation Introduces ExactaMix™ 1200 Automated Compounder for Sterile, Multi-Ingredient Solutions 2Baxa Corporation Introduces ExactaMix™ 1200 Automated Compounder for Sterile, Multi-Ingredient Solutions 3Baxa Corporation Introduces ExactaMix™ 1200 Automated Compounder for Sterile, Multi-Ingredient Solutions 4
... prints labels up to 8.5 ... It is ideal for wide ... chemical drum labels, primary metal ... banner-sized labels and pallet and ...
... Korchek Technologies CareChek Tx, which ... a software device for blood ... match the patient to the ... bedside before administering a transfusion.The ...
... Management system ensures your patients are receiving ... BloodTrack SafeTx uses the AutoPPI™ barcoded wristband ... collection to transfusion. SafeTx checks that the ... need for bedside paperwork and associated transcription ...
... The automated patient ID verification and laboratory ... the identity of the phlebotomist or nurse, the ... request. If proper verification is made, a bar ... the bedside. Its unique design simplifies and eliminates ...
Medicine Products: